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Numrering	Referens	Omslagsbild	Hitta
1.	Cote, P, et al. (författare) Correction to: The global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature 2021 Ingår i: Chiropractic & manual therapies. - : Springer Science and Business Media LLC. - 2045-709X. ; 29:1, s. 11- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract An amendment to this paper has been published and can be accessed via the original article.
2.	Cote, P, et al. (författare) Response to Lawrence DJ: the global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature 2021 Ingår i: Chiropractic & manual therapies. - : Springer Science and Business Media LLC. - 2045-709X. ; 29:1, s. 26- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
3.	McVey, Mark J., et al. (författare) Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat 2021 Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 137:5, s. 690-701 Tidskriftsartikel (refereegranskat)abstract Transfusion-related acute lung injury (TRALI) is a hazardous transfusion complication with an associated mortality of 5% to 15%. We previously showed that stored (5 days) but not fresh platelets (1 day) cause TRALI via ceramide-mediated endothelial barrier dysfunction. As biological ceramides are hydrophobic, extracellular vesicles (EVs) may be required to shuttle these sphingolipids from platelets to endothelial cells. Adding to complexity, EV formation in turn requires ceramide. We hypothesized that ceramide-dependent EV formation from stored platelets and EV-dependent sphingolipid shuttling induces TRALI. EVs formed during storage of murine platelets were enumerated, characterized for sphingolipids, and applied in a murine TRALI model in vivo and for endothelial barrier assessment in vitro. Five-day EVs were more abundant, had higher long-chain ceramide (C16:0, C18:0, C20:0), and lower sphingosine-1-phosphate (S1P) content than 1-day EVs. Transfusion of 5-day, but not 1-day, EVs induced characteristic signs of lung injury in vivo and endothelial barrier disruption in vitro. Inhibition or supplementation of ceramide-forming sphingomyelinase reduced or enhanced the formation of EVs, respectively, but did not alter the injuriousness per individual EV. Barrier failure was attenuated when EVs were abundant in or supplemented with S1P. Stored human platelet 4-day EVs were more numerous compared with 2-day EVs, contained more long-chain ceramide and less S1P, and caused more endothelial cell barrier leak. Hence, platelet-derived EVs become more numerous and more injurious (more long-chain ceramide, less S1P) during storage. Blockade of sphingomyelinase, EV elimination, or supplementation of S1P during platelet storage may present promising strategies for TRALI prevention. Key Points: • EVs derived from stored platelets cause TRALI as a function of their elevated ceramide and decreased S1P content. • Inhibiting ceramide formation, supplementing S1P, or washing stored platelets could potentially reduce TRALI incidence and severity.

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Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: övrigt vetenskapligt/konstnärligt (2); refereegranskat (1)

Författare/redaktör: Engel, R. (2); Axen, I (2); Mior, S (2); Hondras, M (2); Cote, P (2); O'Neill, S (2); visa fler...; Eklund, A (2); De Carvalho, D (2); de Luca, K (2); Page, I (2); Hartvigsen, J (2); Weber, K (2); French, S (2); Leboeuf-Yde, C (2); Gonçalves, G. (2); Cassidy, JD (2); Corso, M (2); Hebert, J (2); Cancelliere, C (2); Hincapié, CA (2); Wong, JS (2); Shearer, H (2); Marchand, AA (2); Kawchuk, GN (2); Poulsen, E (2); Srbely, J (2); Ammendolia, C (2); Blanchette, MA (2); Busse, JW (2); Bussieres, A (2); Christensen, HW (2); Kimpton, A (2); Lauridsen, HH (2); Innes, S (2); Meyer, AL (2); Newell, D (2); Passmore, S (2); Perle, SM (2); Quon, J (2); Rezai, M (2); Stupar, M (2); Swain, M (2); Vitiello, A (2); Young, KJ (2); McVey, Mark J (1); Semple, John W. (1); Du Rose, A (1); Yu, HN (1); Rose, AD (1); Yu, HA (1); visa färre...

Lärosäte: Karolinska Institutet (2); Lunds universitet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

År: 2021 (3)

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