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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu, Yingchang (author)
Day, Felix R (author)
Gustafsson, Stefan (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
show more...
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Na, Jianbo (author)
Bataille, Veronique (author)
Cousminer, Diana L (author)
Dastani, Zari (author)
Drong, Alexander W (author)
Esko, Tõnu (author)
Evans, David M (author)
Falchi, Mario (author)
Feitosa, Mary F (author)
Ferreira, Teresa (author)
Hedman, Åsa K (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
Haring, Robin (author)
Hysi, Pirro G (author)
Iles, Mark M (author)
Justice, Anne E (author)
Kanoni, Stavroula (author)
Lagou, Vasiliki (author)
Li, Rui (author)
Li, Xin (author)
Locke, Adam (author)
Lu, Chen (author)
Mägi, Reedik (author)
Perry, John R B (author)
Pers, Tune H (author)
Qi, Qibin (author)
Sanna, Marianna (author)
Schmidt, Ellen M (author)
Scott, William R (author)
Shungin, Dmitry (author)
Lund University,Lunds universitet,Umeå universitet,Medicin,Institutionen för odontologi,Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Teumer, Alexander (author)
Vinkhuyzen, Anna A E (author)
Walker, Ryan W (author)
Westra, Harm-Jan (author)
Zhang, Mingfeng (author)
Zhang, Weihua (author)
Zhao, Jing Hua (author)
Zhu, Zhihong (author)
Afzal, Uzma (author)
Ahluwalia, Tarunveer Singh (author)
Bakker, Stephan J L (author)
Bellis, Claire (author)
Bonnefond, Amélie (author)
Borodulin, Katja (author)
Buchman, Aron S (author)
Cederholm, Tommy (author)
Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
Choh, Audrey C (author)
Choi, Hyung Jin (author)
Curran, Joanne E (author)
de Groot, Lisette C P G M (author)
De Jager, Philip L (author)
Dhonukshe-Rutten, Rosalie A M (author)
Enneman, Anke W (author)
Eury, Elodie (author)
Evans, Daniel S (author)
Forsen, Tom (author)
Friedrich, Nele (author)
Fumeron, Frédéric (author)
Garcia, Melissa E (author)
Gärtner, Simone (author)
Han, Bok-Ghee (author)
Havulinna, Aki S (author)
Hayward, Caroline (author)
Hernandez, Dena (author)
Hillege, Hans (author)
Ittermann, Till (author)
Kent, Jack W (author)
Kolcic, Ivana (author)
Laatikainen, Tiina (author)
Lahti, Jari (author)
Mateo Leach, Irene (author)
Lee, Christine G (author)
Lee, Jong-Young (author)
Liu, Tian (author)
Liu, Youfang (author)
Lobbens, Stéphane (author)
Loh, Marie (author)
Lyytikäinen, Leo-Pekka (author)
Medina-Gomez, Carolina (author)
Michaëlsson, Karl (author)
Uppsala universitet,Ortopedi
Nalls, Mike A (author)
Nielson, Carrie M (author)
Oozageer, Laticia (author)
Pascoe, Laura (author)
Paternoster, Lavinia (author)
Polašek, Ozren (author)
Ripatti, Samuli (author)
Sarzynski, Mark A (author)
Shin, Chan Soo (author)
Narančić, Nina Smolej (author)
Spira, Dominik (author)
Srikanth, Priya (author)
Steinhagen-Thiessen, Elisabeth (author)
Sung, Yun Ju (author)
Swart, Karin M A (author)
Taittonen, Leena (author)
Tanaka, Toshiko (author)
Tikkanen, Emmi (author)
van der Velde, Nathalie (author)
van Schoor, Natasja M (author)
Verweij, Niek (author)
Wright, Alan F (author)
Yu, Lei (author)
Zmuda, Joseph M (author)
Eklund, Niina (author)
Forrester, Terrence (author)
Grarup, Niels (author)
Jackson, Anne U (author)
Kristiansson, Kati (author)
Kuulasmaa, Teemu (author)
Kuusisto, Johanna (author)
Lichtner, Peter (author)
Luan, Jian'an (author)
Mahajan, Anubha (author)
Männistö, Satu (author)
Palmer, Cameron D (author)
Ried, Janina S (author)
Scott, Robert A (author)
Stancáková, Alena (author)
Wagner, Peter J (author)
Demirkan, Ayse (author)
Döring, Angela (author)
Gudnason, Vilmundur (author)
Kiel, Douglas P (author)
Kühnel, Brigitte (author)
Mangino, Massimo (author)
Mcknight, Barbara (author)
Menni, Cristina (author)
O'Connell, Jeffrey R (author)
Oostra, Ben A (author)
Shuldiner, Alan R (author)
Song, Kijoung (author)
Vandenput, Liesbeth, 1974 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
van Duijn, Cornelia M (author)
Vollenweider, Peter (author)
White, Charles C (author)
Boehnke, Michael (author)
Boettcher, Yvonne (author)
Cooper, Richard S (author)
Forouhi, Nita G (author)
Gieger, Christian (author)
Grallert, Harald (author)
Hingorani, Aroon (author)
Jørgensen, Torben (author)
Jousilahti, Pekka (author)
Kivimaki, Mika (author)
Kumari, Meena (author)
Laakso, Markku (author)
Langenberg, Claudia (author)
Linneberg, Allan (author)
Luke, Amy (author)
Mckenzie, Colin A (author)
Palotie, Aarno (author)
Pedersen, Oluf (author)
Peters, Annette (author)
Strauch, Konstantin (author)
Tayo, Bamidele O (author)
Wareham, Nicholas J (author)
Bennett, David A (author)
Bertram, Lars (author)
Blangero, John (author)
Blüher, Matthias (author)
Bouchard, Claude (author)
Campbell, Harry (author)
Cho, Nam H (author)
Cummings, Steven R (author)
Czerwinski, Stefan A (author)
Demuth, Ilja (author)
Eckardt, Rahel (author)
Eriksson, Johan G (author)
Ferrucci, Luigi (author)
Franco, Oscar H (author)
Froguel, Philippe (author)
Gansevoort, Ron T (author)
Hansen, Torben (author)
Harris, Tamara B (author)
Hastie, Nicholas (author)
Heliövaara, Markku (author)
Hofman, Albert (author)
Jordan, Joanne M (author)
Jula, Antti (author)
Kähönen, Mika (author)
Kajantie, Eero (author)
Knekt, Paul B (author)
Koskinen, Seppo (author)
Kovacs, Peter (author)
Lehtimäki, Terho (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Liu, Yongmei (author)
Orwoll, Eric S (author)
Osmond, Clive (author)
Perola, Markus (author)
Pérusse, Louis (author)
Raitakari, Olli T (author)
Rankinen, Tuomo (author)
Rao, D C (author)
Rice, Treva K (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Salomaa, Veikko (author)
Sørensen, Thorkild I A (author)
Stumvoll, Michael (author)
Tönjes, Anke (author)
Towne, Bradford (author)
Tranah, Gregory J (author)
Tremblay, Angelo (author)
Uitterlinden, André G (author)
van der Harst, Pim (author)
Vartiainen, Erkki (author)
Viikari, Jorma S (author)
Vitart, Veronique (author)
Vohl, Marie-Claude (author)
Völzke, Henry (author)
Walker, Mark (author)
Wallaschofski, Henri (author)
Wild, Sarah (author)
Wilson, James F (author)
Yengo, Loïc (author)
Bishop, D Timothy (author)
Borecki, Ingrid B (author)
Chambers, John C (author)
Cupples, L Adrienne (author)
Dehghan, Abbas (author)
Deloukas, Panos (author)
Fatemifar, Ghazaleh (author)
Fox, Caroline (author)
Furey, Terrence S (author)
Franke, Lude (author)
Han, Jiali (author)
Hunter, David J (author)
Karjalainen, Juha (author)
Karpe, Fredrik (author)
Kaplan, Robert C (author)
Kooner, Jaspal S (author)
McCarthy, Mark I (author)
Murabito, Joanne M (author)
Morris, Andrew P (author)
Bishop, Julia A N (author)
North, Kari E (author)
Ohlsson, Claes, 1965 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Ong, Ken K (author)
Prokopenko, Inga (author)
Richards, J Brent (author)
Schadt, Eric E (author)
Spector, Tim D (author)
Widén, Elisabeth (author)
Willer, Cristen J (author)
Yang, Jian (author)
Ingelsson, Erik (author)
Uppsala universitet,Molekylär epidemiologi
Mohlke, Karen L (author)
Hirschhorn, Joel N (author)
Pospisilik, John Andrew (author)
Zillikens, M Carola (author)
Lindgren, Cecilia (author)
Kilpeläinen, Tuomas Oskari (author)
Loos, Ruth J F (author)
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 (creator_code:org_t)
2016-02-01
2016
English.
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

Keyword

C reactive protein; CRTC1 protein; glucose; GRB14 protein; high density lipoprotein cholesterol; IGF2BP1 protein; insulin; leptin; low density lipoprotein cholesterol; PLA2G6 protein; protein; triacylglycerol; unclassified drug

Publication and Content Type

ref (subject category)
art (subject category)

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Lu, Yingchang
Day, Felix R
Gustafsson, Stef ...
Lind, Lars
Na, Jianbo
Bataille, Veroni ...
show more...
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Dastani, Zari
Drong, Alexander ...
Esko, Tõnu
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Falchi, Mario
Feitosa, Mary F
Ferreira, Teresa
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Haring, Robin
Hysi, Pirro G
Iles, Mark M
Justice, Anne E
Kanoni, Stavroul ...
Lagou, Vasiliki
Li, Rui
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Locke, Adam
Lu, Chen
Mägi, Reedik
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Shungin, Dmitry
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Walker, Ryan W
Westra, Harm-Jan
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Nutrition and Di ...
NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Genetics
Articles in the publication
Nature Communica ...
By the university
Uppsala University
Umeå University
Lund University
Karolinska Institutet
University of Gothenburg

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