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| 2. |
- Fehr, Andre, et al.
(författare)
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Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping.
- 2021
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Ingår i: Virchows Archiv : an international journal of pathology. - : Springer Science and Business Media LLC. - 1432-2307. ; 479
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Tidskriftsartikel (refereegranskat)abstract
- Mucoepidermoid carcinoma (MEC) is the most common carcinoma of the salivary glands. Here, we have used two large patient cohorts with MECs comprising 551 tumors to study clinical, histological, and molecular predictors of survival. One cohort (n = 167), with known CRCT1/3-MAML2 fusion status, was derived from the Hamburg Reference Centre (HRC; graded with the AFIP and Brandwein systems) and the other (n = 384) was derived from the population-based Cancer Registry of North Rhine-Westphalia (LKR-NRW; graded with the AFIP system). The reliability of both the AFIP and Brandwein grading systems was excellent (n = 155). The weighted kappa for inter-rater agreement was 0.81 (95% CI 0.65-0.97) and 0.83 (95% CI 0.71-0.96) for the AFIP and Brandwein systems, respectively. The 5-year relative survival was 79.7% (95% CI 73.2-86.2%). Although the Brandwein system resulted in a higher rate of G3-MECs, survival in G3-tumors (AFIP or Brandwein grading) was markedly worse than in G1/G2-tumors. Survival in > T2 tumors was markedly worse than in those with lower T-stage. Also, fusion-negative MECs had a worse 5-year progression-free survival. The frequency of fusion-positive MECs in the HRC cohort was 78.4%, of which the majority (86.7%) was G1/G2-tumors. In conclusion, the AFIP and Brandwein systems are useful in estimating prognosis and to guide therapy for G3-MECs. However, their significance regarding young age (≤ 30 years) and location-dependent heterogeneity of in particular G2-tumors is more questionable. We conclude that CRTC1/3-MAML2 testing is a useful adjunct to histologic scoring of MECs and for pinpointing tumors with poor prognosis with higher precision, thus avoiding overtreatment.
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| 3. |
- Forbes, Bruce C, et al.
(författare)
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High resilience in the Yamal-Nenets social–ecological system, West Siberian Arctic, Russia
- 2009
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:52, s. 22041-22048
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Tidskriftsartikel (refereegranskat)abstract
- Tundra ecosystems are vulnerable to hydrocarbon development, in part because small-scale, low-intensity disturbances can affect vegetation, permafrost soils, and wildlife out of proportion to their spatial extent. Scaling up to include human residents, tightly integrated arctic social-ecological systems (SESs) are believed similarly susceptible to industrial impacts and climate change. In contrast to northern Alaska and Canada, most terrestrial and aquatic components of West Siberian oil and gas fields are seasonally exploited by migratory herders, hunters, fishers, and domesticated reindeer (Rangifer tarandus L.). Despite anthropogenic fragmentation and transformation of a large proportion of the environment, recent socioeconomic upheaval, and pronounced climate warming, we find the Yamal-Nenets SES highly resilient according to a few key measures. We detail the remarkable extent to which the system has successfully reorganized in response to recent shocks and evaluate the limits of the system's capacity to respond. Our analytical approach combines quantitative methods with participant observation to understand the overall effects of rapid land use and climate change at the level of the entire Yamal system, detect thresholds crossed using surrogates, and identify potential traps. Institutional constraints and drivers were as important as the documented ecological changes. Particularly crucial to success is the unfettered movement of people and animals in space and time, which allows them to alternately avoid or exploit a wide range of natural and anthropogenic habitats. However, expansion of infrastructure, concomitant terrestrial and freshwater ecosystem degradation, climate change, and a massive influx of workers underway present a looming threat to future resilience.
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| 4. |
- Hausner, Vera Helene, et al.
(författare)
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Impacts of climate change and climate extremes on Arctic livelihoods and communities
- 2021. - 1
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Ingår i: Amap arctic climate update 2021. - Tromsö : Arctic Monitoring and Assessment Programme (AMAP). - 9788279712015 ; , s. 107-143
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Key findings:• Climate change is impacting the subsistence harvestbased livelihoods of many small Arctic communities, affecting the quality or supply of traditional food and drinking water, including availability of species to be harvested, and altering transportation access.• Rain-on-snow, extreme snowfall, and variable freezethaw cycles have resulted in severe impacts for reindeer herders. In 2020, multiple snowstorms combined with a late spring thaw resulted in high newborn calf mortality and, together with other social stresses related to Covid-19, created severe crises for reindeer herders in Fennoscandia.• Commercial fisheries are expanding in Arctic shelf ecosystems with warmer oceans and less sea ice. This could benefit local economies and job creation, but may also challenge traditional livelihoods and culture and impact vulnerable Arctic ecosystems. Large uncertainties are associated with the effects of ocean acidification, which could potentially counteract increased commercial fishing opportunities. Commercial fishing is currently prohibited by international agreement in the Central Arctic Ocean.• Warmer water is enabling a northward expansion of salmon farming in the ice-free European Arctic. The aquaculture industry brings employment opportunities and positive ripple effects for local economies, but also has environmental and societal costs that need to be considered in marine spatial planning and regulatory measures.• Arctic cruise tourism is increasing and is attracted to the wildlife associated with the marginal ice zone. Although increased cruise tourism brings the potential for local economic development, adverse local impacts have been reported, including impacts on culture, local hunting and fishing, crowding, and revenue largely benefitting foreign-based individuals and corporations.• Permafrost thaw, flooding, and coastal erosion are causing damage to buildings, roads, and other infrastructure, and pose serious financial and health risks to Arctic residents.• Wildfire occurrence near populated regions in North America and Sweden, and throughout Siberia, in the past five years has resulted in significant economic loss from property damage as well as physical and mental health impacts.• Fishing, cruise tourism, and increased oil and gas operations near the marginal ice zone could increase demand on search and rescue operations and may represent a considerable risk for vulnerable ecosystems. The extent of ice cover is important for determining the fate of an Arctic oil spill and research indicates longer term and more severe ecological impacts from oil spills in the Arctic than in other regions.• Understanding and studying integrated socio-ecological systems, including cumulative and cascading impacts, is important not only in terms of research, but also in terms of risk mitigation, hazard response, climate adaptation,
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| 6. |
- Kumpula, Timo, et al.
(författare)
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Land use and land cover change in Arctic Russia : Ecological and social implications of industrial development
- 2011
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Ingår i: Global Environmental Change. - Oxford : Elsevier. - 0959-3780 .- 1872-9495. ; 21:2, s. 550-562
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Tidskriftsartikel (refereegranskat)abstract
- Sizable areas in northwestern arctic Russia have undergone fundamental change in recent decades as the exploration of vast hydrocarbon deposits has intensified. We undertook two case studies on the influence of oil and gas activities within neighbouring federal districts in the tundra zone. Employing a strongly interdisciplinary approach, we studied the ecological, spatial and social dimensions of the visible and perceived changes in land use and land cover. Our data are derived from field sampling, remote sensing and intensive participant observation with indigenous Nenets reindeer herders and non-indigenous workers. Important trends include the rapid expansion of infrastructure, a large influx of workers who compete for freshwater fish, and extensive transformation from shrub- to grass- and sedge-dominated tundra. The latter represents an alternative ecosystem state that is likely to persist indefinitely. On terrain disturbed by off-road vehicle traffic, reindeer pastures' vegetation regenerates with fewer species among which grasses and sedges dominate, thus reducing biodiversity. To have maximum forage value such pastures must be accessible and free of trash, petro-chemicals and feral dogs. We found that a wide range of direct and indirect impacts, both ecological and social, accumulate in space and time such that the combined influence is effectively regional rather than local, depending in part on the placement of facilities. While incoming workers commonly commit poaching, they also serve as exchange partners, making barter for goods possible in remote locations. In general, the same positive and negative impacts of the presence of industry were mentioned in each study region. Even using very high-resolution remote sensing data (Quickbird-2) it is not possible to determine fully the amount of degraded territory in modern oil and gas fields. With regard to policy, both biophysical and social impacts could be substantially reduced if information flow between herders and workers were to be optimized. (C) 2011 Elsevier Ltd. All rights reserved.
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| 8. |
- Sehlin MacNeil, Kristina, 1975-
(författare)
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Extractive Violence on Indigenous Country : sami and Aboriginal Views on Conflicts and Power Relations with Extractive Industries
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Asymmetrical conflicts and power relations between extractive industries and Indigenous groups often have devastating consequences for Indigenous peoples. Many Indigenous groups are struggling to maintain their lands as Indigenous perspectives on connection to Country are frequently undervalued or dismissed in favour of extractivist ideologies. While this conflicted interface has been researched in various parts of the world, studies exploring conflicts and power relations with extractive industries from Indigenous perspectives are few.This thesis is an international comparison aiming to illuminate situations of conflict and asymmetrical power relations caused by extractivism on Indigenous lands from new viewpoints. By drawing on two single case studies, the situations for Laevas reindeer herding Sami community in northern Sweden and Adnyamathanha Traditional Owners in South Australia are compared and contrasted. Yarning (a form of interviewing) is used as a method for data collection and in order to stay as true as possible to the research participants’ own words a number of direct quotes are used. The analysis employs peace researcher Johan Galtung’s concepts of cultural and structural violence as analytical tools to further explore the participants’ experiences of interactions with extractive industries and industrial proponents, including governments. In addition, the thesis introduces the concept of extractive violence as a complement to Galtung’s model. Extractive violence is defined as a form of direct violence against people and/or animals and nature caused by extractivism, which predominantly impacts peoples closely connected to land. The concepts of structural and cultural violence are understood as unjust societal structures and racist and discriminating attitudes respectively.A number of main themes could be identified in the research participants’ narratives. However, the most prominent on both continents was connections to Country and the threat that extractive violence posed to these connections.The results show that although the expressions of cultural, structural and extractive violence experienced by the two Indigenous communities varied, the impacts were strikingly similar. Both communities identified extractive violence, supported by structural and cultural violence, as threats to the continuation of their societies and entire cultures. Furthermore, the results suggest that in order to address violence against Indigenous peoples and achieve conflict transformation, Indigenous and decolonising perspectives should be heard and taken into account.
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| 9. |
- Uboni, Alessia, et al.
(författare)
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Long-Term Trends and Role of Climate in the Population Dynamics of Eurasian Reindeer
- 2016
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:6
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Tidskriftsartikel (refereegranskat)abstract
- Temperature is increasing in Arctic and sub-Arctic regions at a higher rate than anywhere else in the world. The frequency and nature of precipitation events are also predicted to change in the future. These changes in climate are expected, together with increasing human pressures, to have significant impacts on Arctic and sub-Arctic species and ecosystems. Due to the key role that reindeer play in those ecosystems, it is essential to understand how climate will affect the region's most important species. Our study assesses the role of climate on the dynamics of fourteen Eurasian reindeer (Rangifer tarandus) populations, using for the first time data on reindeer abundance collected over a 70-year period, including both wild and semi-domesticated reindeer, and covering more than half of the species' total range. We analyzed trends in population dynamics, investigated synchrony among population growth rates, and assessed the effects of climate on population growth rates. Trends in the population dynamics were remarkably heterogeneous. Synchrony was apparent only among some populations and was not correlated with distance among population ranges. Proxies of climate variability mostly failed to explain population growth rates and synchrony. For both wild and semi-domesticated populations, local weather, biotic pressures, loss of habitat and human disturbances appear to have been more important drivers of reindeer population dynamics than climate. In semi-domesticated populations, management strategies may have masked the effects of climate. Conservation efforts should aim to mitigate human disturbances, which could exacerbate the potentially negative effects of climate change on reindeer populations in the future. Special protection and support should be granted to those semi-domesticated populations that suffered the most because of the collapse of the Soviet Union, in order to protect the livelihood of indigenous peoples that depend on the species, and the multi-faceted role that reindeer exert in Arctic ecosystems.
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| 10. |
- Walker, Donald A., et al.
(författare)
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Cumulative Effects of Rapid Land-Cover and Land-Use Changes on the Yamal Peninsula, Russia
- 2011
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Ingår i: Eurasian Arctic Land Cover and Land Use in a Changing Climate. - New York : Springer Netherlands. - 9789048191178 - 9789048191185 ; , s. 207-236
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The Yamal Peninsula in northwest Siberia is undergoing some of the most rapid land-cover and land-use changes in the Arctic due to a combination of gas development, reindeer herding, and climate change. Unusual geological conditions (nutrient-poor sands, massive ground ice and extensive landslides) exacerbate the impacts. These changes will likely increase markedly as transportation corridors are built to transport the gas to market. Understanding the nature, extent, causes and consequences (i.e., the cumulative effects) of the past and ongoing rapid changes on the Yamal is important for effective, long-term decision-making and planning. The cumulative effects to vegetation are the focus of this chapter because the plants are a critical component of the Yamal landscape that support the indigenous Nenets people and their reindeer and also protect the underlying ice-rich permafrost from melting. We are using a combination of ground-based studies (a transect of live locations across the Yamal), remote-sensing studies, and analyses of Nenets land-use activities to develop vegetation-change models that can be used to help anticipate future states of the tundra and how those changes might affect traditional reindeer herding practices and the thermal state of the permafrost. This chapter provides an overview of the approach, some early results, and recommendations for expanding the concept of cumulative-effects analysis to include examining the simultaneous and interactive effects of multiple drivers of change.
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