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- Manry, Jérémy, et al.
(författare)
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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:21
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Tidskriftsartikel (refereegranskat)abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
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- Milham, Michael P., et al.
(författare)
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An Open Resource for Non-human Primate Imaging
- 2018
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Ingår i: Neuron. - : Elsevier BV. - 0896-6273 .- 1097-4199. ; 100:1, s. 61-74
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Tidskriftsartikel (refereegranskat)abstract
- Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets.
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- Coudert, S., et al.
(författare)
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Double large field stereoscopic PIV in a high Reynolds number turbulent boundary layer
- 2011
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Ingår i: Experiments in Fluids. - : Springer Science and Business Media LLC. - 1432-1114 .- 0723-4864. ; 50:1, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- An experiment on a flat plate turbulent boundary layer at high Reynolds number has been carried out in the Laboratoire de Mecanique de Lille (LML, UMR CNRS 8107) wind tunnel. This experiment was performed jointly with LEA (UMR CNRS 6609) in Poitiers (France) and Chalmers University of Technology (Sweden), in the frame of the WALLTURB European project. The simultaneous recording of 143 hot wires in one transverse plane and of two perpendicular stereoscopic PIV fields was performed successfully. The first SPIV plane is 1 cm upstream of the hot wire rake and the second is both orthogonal to the first one and to the wall. The first PIV results show a blockage effect which based on both statistical results (i.e. mean, RMS and spatial correlation) and a potential model does not seem to affect the turbulence organization.
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- Delville, J., et al.
(författare)
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The WALLTURB joined experiment to assess the large scale structures in a high reynolds number turbulent boundary layer
- 2011
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Ingår i: ERCOFTAC Series. - Dordrecht : Springer Netherlands. - 1382-4309 .- 2215-1826. - 9789048196029 ; 14, s. 64-73
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Konferensbidrag (refereegranskat)abstract
- Experiments, involving the joint effort of three European teams and aiming at using the state-of-the-art techniques to study the dynamics of the high Reynolds turbulent boundary layer, have been performed in June 2006 in the LML large wind tunnel. A set of four stereoscopic PIV systems and a rake of 143 hot wires were used to provide synchronised measurements. This paper summarises these ex-periments, presents sample results of both PIV and hot-wire rake data and illustrates the complementarity of such a coupled approach that combines the advantages of each technique.
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- Gendre, Delphine, et al.
(författare)
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Rho-of-plant activated root hair formation requires Arabidopsis YIP4a/b gene function
- 2019
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Ingår i: Development. - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 146:5
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Tidskriftsartikel (refereegranskat)abstract
- Root hairs are protrusions from root epidermal cells with crucial roles in plant soil interactions. Although much is known about patterning, polarity and tip growth of root hairs, contributions of membrane trafficking to hair initiation remain poorly understood. Here, we demonstrate that the trans-Golgi network-localized YPT-INTERACTING PROTEIN 4a and YPT-INTERACTING PROTEIN 4b (YIP4a/b) contribute to activation and plasma membrane accumulation of Rho-of-plant (ROP) small GTPases during hair initiation, identifying YIP4a/b as central trafficking components in ROP-dependent root hair formation.
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