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A randomized phase ...
A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer
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- Glimelius, Bengt (författare)
- Karolinska Institutet,Uppsala universitet,Enheten för onkologi,Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
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- Sorbye, H. (författare)
- Sørbye, H., Department of Oncology, Haukeland University Hospital, Bergen, Norway
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- Balteskard, L. (författare)
- Department of Oncology, University Hospital, Tromsö, Norway
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- Bystrom, P. (författare)
- Byström, P., Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
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- Pfeiffer, P. (författare)
- Department of Oncology, University Hospital, Odense, Denmark
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- Tveit, K. (författare)
- Department of Oncology, Ullevål University Hospital, Oslo, Norway
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- Heikkila, R. (författare)
- Heikkilä, R., Department of Hemato-Oncology, Stavanger University Hospital, Stavanger, Norway
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- Keldsen, N. (författare)
- Department of Oncology, Central Hospital, Herning, Denmark
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- Albertsson, M. (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, University Hospital, Malmö, Sweden
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- Starkhammar, Hans (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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- Garmo, H (författare)
- Regional Oncologic Center, Uppsala, Sweden
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- Berglund, Åke (författare)
- Uppsala universitet,Enheten för onkologi,Berglund, Å., Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 19:5, s. 909-914
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: To compare irinotecan with the Nordic 5-fluorouracil (5-FU) and folinic acid (FA) bolus schedule [irinotecan 180 mg/m2 on day 1, 5-FU 500 mg/m2 and FA 60 mg/m2 on day 1 and 2 (FLIRI)] or the Lv5FU2 schedule [irinotecan 180 mg/m2 on day 1, FA 200 mg/m2, 5-FU bolus 400 mg/m2 and infused 5-FU 600 mg/m2 on day 1 and 2 (Lv5FU2-IRI)] due to uncertainties about how to administrate 5-FU with irinotecan. Patients and methods: Patients (n = 567) with metastatic colorectal cancer were randomly assigned to receive FLIRI or Lv5FU2-IRI. Primary end point was progression-free survival (PFS). Results: Patient characteristics were well balanced. PFS did not differ between groups (median 9 months, P = 0.22). Overall survival (OS) was also similar (median 19 months, P = 0.9). Fewer objective responses were seen in the FLIRI group (35% versus 49%, P = 0.001) but the metastatic resection rate did not differ (4% versus 6%, P = 0.3). Grade 3/4 neutropenia (11% versus 5%, P = 0.01) and grade 2 alopecia (18% versus 9%, P = 0.002) were more common in the FLIRI group. The 60-day mortality was 2.4% versus 2.1%. Conclusions: Irinotecan with the bolus Nordic schedule (FLIRI) is a convenient treatment with PFS and OS comparable to irinotecan with the Lv5FU2 schedule. Neutropenia and alopecia are more prevalent, but both regimens are equally well tolerated. © The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- 5-fluorouracil
- Chemotherapy
- Colorectal cancer
- Irinotecan
- Randomized trial
- MEDICINE
- MEDICIN
- chemotherapy
- irinotecan
- 5-fluorouracil
- randomized trial
- colorectal cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Glimelius, Bengt
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Sorbye, H.
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Balteskard, L.
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Bystrom, P.
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Pfeiffer, P.
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Tveit, K.
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Heikkila, R.
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Keldsen, N.
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Albertsson, M.
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Starkhammar, Han ...
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Garmo, H
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Berglund, Åke
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och Klinisk medicin
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- Av lärosätet
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Linköpings universitet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet