Search: WFRF:(Starkhammar H)
> Jakobsen A >
Adjuvant chemothera...
Adjuvant chemotherapy in colorectal cancer: a joint analysis of randomised trials by the Nordic Gastrointestinal Tumour Adjuvant Therapy Group
-
- Glimelius, Bengt (author)
- Karolinska Institutet
-
Dahl, O. (author)
-
- Cedermark, B. (author)
- Karolinska Institutet
-
show more...
-
Jakobsen, A. (author)
-
Bentzen, S. M. (author)
-
- Starkhammar, Hans, 1948- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
-
- Gronberg, H. (author)
- Karolinska Institutet,Umeå universitet,Onkologi
-
- Hultborn, Ragnar, 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
-
- Albertsson, Maria (author)
- Linköpings universitet,Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
-
- Pahlman, Lars (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal
-
Tveit, K. M. (author)
-
show less...
-
(creator_code:org_t)
- Informa UK Limited, 2005
- 2005
- English.
-
In: Acta Oncol. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 44:8, s. 904-12
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
http://www.ncbi.nlm....
-
https://gup.ub.gu.se...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Due to uncertainties regarding clinically meaningful gains from adjuvant chemotherapy after colorectal cancer surgery, several Nordic Groups in the early 1990s initiated randomised trials to prove or reject such gains. This report gives the joint analyses after a minimum 5-year follow-up. Between October 1991 and December 1997, 2 224 patients under 76 years of age with colorectal cancer stages II and III were randomised to surgery alone (n = 1 121) or adjuvant chemotherapy (n = 1 103) which varied between trials (5FU/levamisole for 12 months, n = 444; 5FU/leucovorin for 4-5 months according to either a modified Mayo Clinic schedule (n = 262) or the Nordic schedule (n = 397). Some centres also randomised patients treated with 5FU/leucovorin to+/-levamisole). A total of 812 patients had colon cancer stage II, 708 colon cancer stage III, 323 rectal cancer stage II and 368 rectal cancer stage III. All analyses were according to intention-to-treat. No statistically significant difference in overall survival, stratified for country or region, could be found in any group of patients according to stage or site. In colon cancer stage III, an absolute difference of 7% (p = 0.15), favouring chemotherapy, was seen. The present analyses corroborate a small but clinically meaningful survival gain from adjuvant chemotherapy in colon cancer stage III, but not in the other presentations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adenocarcinoma/drug therapy/surgery
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
- Chemotherapy
- Adjuvant
- Colorectal Neoplasms/*drug therapy/surgery
- Combined Modality Therapy
- Female
- Fluorouracil/administration & dosage
- Humans
- Leucovorin/administration & dosage
- Levamisole/administration & dosage
- Male
- Middle Aged
- Neoplasm Staging
- Survival Rate
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Acta Oncol
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Glimelius, Bengt
-
Dahl, O.
-
Cedermark, B.
-
Jakobsen, A.
-
Bentzen, S. M.
-
Starkhammar, Han ...
-
show more...
-
Gronberg, H.
-
Hultborn, Ragnar ...
-
Albertsson, Mari ...
-
Pahlman, Lars
-
Tveit, K. M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Acta Oncol
- By the university
-
University of Gothenburg
-
Lund University
-
Umeå University
-
Uppsala University
-
Karolinska Institutet
-
Linköping University