Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Stattin P) "

Sökning: WFRF:(Stattin P)

Sortera/gruppera träfflistan
  • Gusev, Alexander, et al. (författare)
  • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
  • 2016
  • Ingår i: Nature communications. - 2041-1723. ; 7, s. 10979
  • Tidskriftsartikel (refereegranskat)abstract
    • Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
  • Wang, Zhaoming, et al. (författare)
  • Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
  • 2014
  • Ingår i: Human Molecular Genetics. - 0964-6906. ; 23:24, s. 6616-6633
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
  • Allen, N E, et al. (författare)
  • Animal foods, protein, calcium and prostate cancer risk : the European Prospective Investigation into Cancer and Nutrition.
  • 2008
  • Ingår i: Br J Cancer. - 1532-1827. ; 98:9, s. 1574-81
  • Tidskriftsartikel (refereegranskat)abstract
    • We examined consumption of animal foods, protein and calcium in relation to risk of prostate cancer among 142 251 men in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by recruitment centre and adjusted for height, weight, education, marital status and energy intake. After an average of 8.7 years of follow-up, there were 2727 incident cases of prostate cancer, of which 1131 were known to be localised and 541 advanced-stage disease. A high intake of dairy protein was associated with an increased risk, with a hazard ratio for the top versus the bottom fifth of intake of 1.22 (95% confidence interval (CI): 1.07-1.41, P-trend = 0.02). After calibration to allow for measurement error, we estimated that a 35-g day(-1) increase in consumption of dairy protein was associated with an increase in the risk of prostate cancer of 32% (95% CI: 1-72%, P-trend = 0.04). Calcium from dairy products was also positively associated with risk, but not calcium from other foods. The results support the hypothesis that a high intake of protein or calcium from dairy products may increase the risk for prostate cancer.
  • Hallmans, Göran, et al. (författare)
  • Rye, lignans and human health
  • 2003
  • Ingår i: Proceedings of the Nutrition Society. - 0029-6651. ; 62:1, s. 193-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Rye bran contains a high content not only of dietary fibre, but also of plant lignans and other bioactive compounds in the so-called dietary fibre complex. Blood concentrations of lignans such as enterolactone have been used as biomarkers of intake of lignan-rich plant food. At present,evidence from studies in human subjects does not warrant the conclusion that rye, whole grains orphyto-oestrogens protect against cancer. Some studies, however, have pointed in that direction,especially in relation to cancers of the upper digestive tract. A number of prospective epidemiological studies have clearly shown a protective effect of wholegrain cereals against myocardial infarctions. A corresponding protective effect against diabetes and ischaemic stroke(brain infarct) has also been demonstrated. It seems reasonable to assume that these protective effects are associated with one or more factors in the dietary fibre complex.
  • Scelo, G, et al. (författare)
  • International cancer seminars : a focus on kidney cancer
  • 2016
  • Ingår i: Annals of Oncology. - 0923-7534. ; 27:8, s. 1382-1385
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent years have seen important advances in our understanding of the etiology, biology and genetics of kidney cancer. To summarize important achievements and identify prominent research questions that remain, a workshop was organized by IARC and the US NCI. A series of 'difficult questions' were formulated, which should be given future priority in the areas of population, genomic and clinical research.Recent years have seen important advances in our understanding of the etiology, biology and genetics of kidney cancer. To summarize important achievements and identify prominent research questions that remain, a workshop was organized by IARC and the US NCI. A series of 'difficult questions' were formulated, which should be given future priority in the areas of population, genomic and clinical research.
  • Stattin, Eva-Lena, et al. (författare)
  • SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts.
  • 2017
  • Ingår i: Scientific Reports. - 2045-2322 .- 2045-2322. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Autosomal recessive osteopetrosis (ARO) is a heterogeneous disorder, characterized by defective osteoclastic resorption of bone that results in increased bone density. We have studied nine individuals with an intermediate form of ARO, from the county of Västerbotten in Northern Sweden. All afflicted individuals had an onset in early infancy with optic atrophy, and in four patients anemia was present at diagnosis. Tonsillar herniation, foramen magnum stenosis, and severe osteomyelitis of the jaw were common clinical features. Whole exome sequencing, verified by Sanger sequencing, identified a splice site mutation c.212 + 1 G > T in the SNX10 gene encoding sorting nexin 10. Sequence analysis of the SNX10 transcript in patients revealed activation of a cryptic splice site in intron 4 resulting in a frame shift and a premature stop (p.S66Nfs * 15). Haplotype analysis showed that all cases originated from a single mutational event, and the age of the mutation was estimated to be approximately 950 years. Functional analysis of osteoclast progenitors isolated from peripheral blood of patients revealed that stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) resulted in a robust formation of large, multinucleated osteoclasts which generated sealing zones; however these osteoclasts exhibited defective ruffled borders and were unable to resorb bone in vitro.
Skapa referenser, mejla, bekava och länka
fritt online (18)
Typ av publikation
tidskriftsartikel (81)
konferensbidrag (11)
annan publikation (2)
recension (1)
Typ av innehåll
refereegranskat (81)
övrigt vetenskapligt (14)
Stattin, P (55)
Stattin, Pär, (29)
LAMBE, M, (11)
Bergh, Anders, (10)
Egevad, Lars, (10)
Garmo, H. (10)
visa fler...
Robinson, D. (9)
Kaaks, R (9)
Adolfsson, J. (9)
Egevad, L, (9)
Riboli, E (8)
Bratt, Ola (8)
Hallmans, Göran, (8)
Hallmans, G (8)
Granfors, Torvald (7)
Riboli, Elio (6)
Giles, Graham G (6)
Rinaldi, S (6)
Overvad, K (5)
Linseisen, J (5)
Bill-Axelson, A (5)
Hammarsten, Peter, (5)
Albanes, Demetrius (5)
Travis, Ruth C (5)
Bratt, O (5)
Le Marchand, Loïc (5)
Boeing, H (4)
Kaaks, Rudolf (4)
Bueno-de-Mesquita, H ... (4)
Johansson, E, (4)
Johansson, JE (4)
Dillner, Joakim, (4)
Hägglöf, Christina, (4)
Hagglof, C (4)
Donovan, Jenny L (4)
Haiman, Christopher ... (4)
Gronberg, H, (4)
Carlsson, S, (4)
Lophatananon, A (4)
Palli, D (4)
Allen, Naomi E (4)
Josefsson, Andreas (4)
Hoover, Robert N. (4)
Trichopoulou, A (4)
Wiklund, F, (4)
Granfors, T (4)
Larrañaga, N (4)
Sánchez, M-J (4)
Khaw, K-T (4)
visa färre...
Karolinska Institutet (58)
Umeå universitet (42)
Uppsala universitet (25)
Göteborgs universitet (14)
Lunds universitet (14)
Linköpings universitet (2)
visa fler...
Luleå tekniska universitet (1)
Örebro universitet (1)
Chalmers tekniska högskola (1)
Högskolan Dalarna (1)
visa färre...
Engelska (93)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (54)
Lantbruksvetenskap (3)
Naturvetenskap (1)


pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy