SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Stegmayr Birgitta) ;pers:(Hallmans Göran)"

Sökning: WFRF:(Stegmayr Birgitta) > Hallmans Göran

  • Resultat 1-10 av 15
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Ekblom, Kim, 1970-, et al. (författare)
  • Iron stores and HFE genotypes are not related to increased risk of ischemic stroke. : a prospective nested case-referent study
  • 2007
  • Ingår i: Cerebrovascular Diseases. - : S. Karger AG. - 1015-9770 .- 1421-9786. ; 24:5, s. 405-411
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: High iron levels can increase the formation of noxious oxygen radicals, which are thought to contribute to cerebrovascular disease. The aim of this prospective study was to determine if iron status and HFE genotypes constitute risk factors for stroke. Methods: First-ever stroke cases (231 ischemic and 42 hemorrhagic) and matched double referents from the population-based Northern Sweden cohorts were studied in a nested case-referent setting. Results: For total iron binding capacity, an increased risk of ischemic stroke was seen in the highest quartile (OR 1.80; 95% CI 1.14-2.83; p for trend 0.012). The highest quartile of transferrin iron saturation showed a decreased risk of ischemic stroke in men (OR 0.44; 95% CI 0.22-0.87; p for trend 0.028), but not in women. There was an increased risk of hemorrhagic stroke in the second (OR 4.07; 95% CI 1.09-15.20) and third quartile (OR 4.22; 95% CI 1.08-16.42) of ferritin. Neither quartiles of plasma iron concentrations nor the HFE C282Y and H63D genotypes were associated with ischemic or hemorrhagic stroke. Conclusions: Iron stores were not positively related to increased risk of ischemic stroke. Furthermore, HFE genotypes did not influence the risk of ischemic or hemorrhagic stroke. Copyright (c) 2007 S. Karger AG, Basel.
  •  
3.
  • Fiskesund, Roland, et al. (författare)
  • Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden
  • 2010
  • Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 41:4, s. 607-612
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND PURPOSE: Natural immunoglobulin M antibodies specific for phosphorylcholine (anti-PC) have been implicated in atherosclerosis. We have shown previously that high levels of anti-PC predict a slower progression of atherosclerosis in humans and that low levels of anti-PC are associated with higher risk for cardiovascular disease. Here we determine the association between anti-PC and the incidence of stroke. METHODS: Using a nested case control study design, we examined 227 incident cases (125 men and 102 women) of first-time stroke and 455 age- and sex-matched controls identified during a 13-year time period (1985 to 1999) within the population-based cohorts of the Västerbotten Intervention Project (VIP) and the World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease (WHO MONICA) project in Northern Sweden. Odds ratios of stroke with 95% CIs with adjustments for age, gender, smoking, serum cholesterol, diabetes, body mass index, and blood pressure were determined. Anti-PC levels were measured using ELISA. RESULTS: A significant association between low levels of anti-PC at baseline and incident stroke was seen for the whole group of anti-PC levels below the 30th percentile (multivariately adjusted odds ratio, 1.62; CI, 1.11 to 2.35). Analyses of gender-specific associations indicated fairly strong associations for females, especially at the lowest 30th percentile (multivariately adjusted odds ratio, 2.65; CI, 1.41 to 4.95). No associations were noted for men. CONCLUSION: Low anti-PC is a novel independent risk marker for development of stroke. Measurements of anti-PC could be used to identify immunodeficient subjects at an increased risk for stroke. The possibility that such subjects might be targets for novel modes of treatment such as immunotherapies deserves further investigation.
  •  
4.
  • Hallmans, Göran, et al. (författare)
  • Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort : evaluation of risk factors and their interactions.
  • 2003
  • Ingår i: Scandinavian Journal of Public Health. Supplement Links. - : SAGE Publications. - 1403-4956 .- 1403-4948 .- 1651-1905. ; 61, s. 18-24
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this paper is, first, to describe the organization, sampling procedures, availability of samples/database, ethical considerations, and quality control program of the Northern Sweden Health and Disease Study Cohort. Secondly, some examples are given of studies on cardiovascular disease and diabetes with a focus on the biomarker programme. The cohort has been positioned as a national and international resource for scientific research.
  •  
5.
  • Hultdin, Johan, et al. (författare)
  • Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C > T and 1298A > C genotypes and haplotypes : evidence for an association with hemorrhagic stroke
  • 2011
  • Ingår i: Clinical Chemistry and Laboratory Medicine. - Berlin : Walter de Gruyter. - 1434-6621 .- 1437-4331. ; 49:9, s. 1555-1562
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Abnormalities in homocysteine metabolism have been suggested as risk factors for stroke. The aim of this prospective study was to examine whether total plasma homocysteine concentration (tHcy) and its main genetic determinant, methylene tetrahydrofolate reductase (MTHFR) polymorphisms, were associated with first ischemic or hemorrhagic stroke.Methods: This was a nested case-referent study of 321 ischemic and 60 hemorrhagic stroke cases, defined by WHO MONICA criteria and each matched with two event-free referents for sex, age, cohort, recruitment date and geographical area. All subjects were from the population-based Northern Sweden Health and Disease Study cohorts. Odds ratios were determined by conditional logistic regression.Results: The mean follow-up time was 4.2 years. Both tHcy and MTHFR were independent predictors of hemorrhagic stroke in multivariate models including body mass index, hypertension and, for MTHFR, tHcy [OR for the highest vs. lowest tHcy quartile 8.13 (95% CI 1.83-36.1), p(trend)=0.002; OR for MTHFR 677TT vs. 677CC genotype 3.62 (95% CI 0.77-17.0), p(trend)=0.040]. Haplotype analyses confirmed that the MTHFR 677T-1298A haplotype was positively associated with hemorrhagic stroke [OR 1.81 (95% CI 1.09-3.00), p=0.022], whereas the MTHFR 677C-1298C haplotype was not significantly related to either hemorrhagic or ischemic stroke. Neither tHcy nor the MTHFR polymorphisms were significant predictors of ischemic stroke.Conclusion: Both elevated plasma homocysteine levels and the MTHFR 677T allele are indicators of increased risk of hemorrhagic stroke in the northern Swedish population.
  •  
6.
  • Johansson, Anders, et al. (författare)
  • Systemic antibodies to the leukotoxin of the oral pathogen Actinobacillus actinomycetemcomitans correlate negatively with stroke in women
  • 2005
  • Ingår i: Cerebrovascular Diseases. - Basel : Karger. - 1015-9770 .- 1421-9786. ; 20:4, s. 226-232
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Chronic infections and associated inflammatory markers are suggested risk factors for cardiovascular diseases (CVD) and stroke. The proinflammatory cytokine interleukin (IL)-1β is suggested to play a role in the regulation of local inflammatory responses in both CVD and periodontitis. The leukotoxin from the periodontal pathogen Actinobacillus actinomycetemcomitans has recently been shown to cause abundant secretion of IL-1β  from macrophages. The aim of the present study was to compare the prevalence of systemic antibodies to A. actinomycetemcomitansleukotoxin in stroke cases (n = 273) and matched controls (n = 546) in an incident case-control study nested within the Northern Sweden MONICA and Västerbotten Intervention cohorts. Methods: Antibodies to A. actinomycetemcomitans leukotoxin were analyzed in a bioassay with HL-60 cells (leukocytes), purified A. actinomycetemcomitans leukotoxin, and plasma. Plasma samples which inhibited lactate dehydrogenase release from leukotoxin-lysed cells by ≥50% were classified as antibody positive. Results: Antibodies to A. actinomycetemcomitans leukotoxin were detected in 18.8% of the women and 15.2% of the men. Women with those antibodies had a significantly decreased risk for stroke (OR = 0.28, 95% CI: 0.13–0.59), but not men (OR = 0.88, 95% CI: 0.52–1.51). Conclusion: The immunoreactivity to A. actinomycetemcomitans leukotoxin correlates negatively with a future stroke in woman, but not in men. Further studies are needed to explain the underlying mechanisms, as well as the biological relevance of this finding.
  •  
7.
  • Johansson, Ingegerd, et al. (författare)
  • Associations among 25-year trends in diet, cholesterol and BMI from 140,000 observations in men and women in Northern Sweden
  • 2012
  • Ingår i: Nutrition Journal. - : Springer Science and Business Media LLC. - 1475-2891 .- 1475-2891. ; 11
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: In the 1970s, men in northern Sweden had among the highest prevalences of cardiovascular diseases (CVD) worldwide. An intervention program combining population- and individual-oriented activities was initiated in 1985. Concurrently, collection of information on medical risk factors, lifestyle and anthropometry started. Today, these data make up one of the largest databases in the world on diet intake in a population- based sample, both in terms of sample size and follow-up period. The study examines trends in food and nutrient intake, serum cholesterol and body mass index (BMI) from 1986 to 2010 in northern Sweden.Methods: Cross-sectional information on self-reported food and nutrient intake and measured body weight, height, and serum cholesterol were compiled for over 140,000 observations. Trends and trend breaks over the 25-year period were evaluated for energy-providing nutrients, foods contributing to fat intake, serum cholesterol and BMI.Results: Reported intake of fat exhibited two significant trend breaks in both sexes: a decrease between 1986 and 1992 and an increase from 2002 (women) or 2004 (men). A reverse trend was noted for carbohydrates, whereas protein intake remained unchanged during the 25-year period. Significant trend breaks in intake of foods contributing to total fat intake were seen. Reported intake of wine increased sharply for both sexes (more so for women) and export beer increased for men. BMI increased continuously for both sexes, whereas serum cholesterol levels decreased during 1986 - 2004, remained unchanged until 2007 and then began to rise. The increase in serum cholesterol coincided with the increase in fat intake, especially with intake of saturated fat and fats for spreading on bread and cooking.Conclusions: Men and women in northern Sweden decreased their reported fat intake in the first 7 years (19861992) of an intervention program. After 2004 fat intake increased sharply for both genders, which coincided with introduction of a positive media support for low carbohydrate-high-fat (LCHF) diet. The decrease and following increase in cholesterol levels occurred simultaneously with the time trends in food selection, whereas a constant increase in BMI remained unaltered. These changes in risk factors may have important effects on primary and secondary prevention of cardiovascular disease (CVD).
  •  
8.
  •  
9.
  • Lindahl, Bernt, et al. (författare)
  • Trends in lifestyle 1986-99 in a 25- to 64-year-old population of the Northern Sweden MONICA project.
  • 2003
  • Ingår i: Scandinavian Journal of Public Health. Supplement. - : SAGE Publications. - 1403-4956 .- 1403-4948 .- 1651-1905. ; 61, s. 31-7
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS: The authors explore the time trends in lifestyle factors in the Northern Sweden MONICA population, including physical activity, intake of certain foods, coffee and alcohol consumption, smoking, and the use of smokeless tobacco. METHODS: Four health surveys during a 14-year time span were compared (1986, 1990, 1994, and 1999). The participation rate in all surveys was high. A questionnaire with similar or comparable questions about lifestyle factors was used across all health surveys. RESULTS: A large variation was demonstrated in the consumption of saturated fat in dairy products across the surveys. The use of butter on bread and of 3% fat milk clearly declined in favour of using low-fat margarine and 1-1.5% fat milk. A decline in the intake of boiled or baked potatoes together with an increase in the intake of pasta and rice was demonstrated. There were no changes in leisure-time physical activity. The proportion of the population using tobacco was unaltered. In men, smoking declined during the period but simultaneously there was an increase in the use of smokeless tobacco. The use of "boiled" or Scandinavian coffee diminished and more frequent use of alcohol was seen, especially in men. CONCLUSION: Pronounced changes were seen in food consumption with a decrease in saturated fat intake, boiled coffee, and potatoes and an increase in alcohol, rice, and pasta consumption. No clear time trends were found in physical activity or in the use of tobacco.
  •  
10.
  • Lundh, Thomas, et al. (författare)
  • Spårelement i blodkroppar från väster- och norrbottningar 1990-99
  • 2002
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Sexton spårelement bestämdes i blodkroppar från 600 kvinnor och män i åldrarna 25-74 år från Västerbotten och Norrbotten. Med Induktiv kopplad plasma (ICP-MS) bestämdes aluminium (Al), vanadin (V), mangan (Mn), kobolt (Co), nickel (Ni), koppar (CU), zink (Zn), selen (Se), rodium (Rh), palladium (Pd), kadmium (Cd), antimon (Sb), wolfram (W), platina (Pt) och bly (Pb). Dessutom bestämdes med atomfluorescens kvicksilver (Hg). Cd-koncentrationerna är av en nivå som kopplats samman med lätt toxicitet. Medianhalterna av Pb och Hg ligger långt under de som satts i samband med toxiska effekter. Variationen var emellertid hög; de högsta halterna är i nivå med dem som anses kunna orsaka ogynnsamma effekter. I en multivariat modell utvärderades effekter av kön, ålder, rökvanor och kalenderår. Framför allt för Cd, men i viss mån också för Hg, hade rökare högre halter än icke-rökare. Kvinnor hade högre halter av Cd och Pb än män. Det fanns klart stigande halter av Cd och Hg med stigande ålder. Vid jämförelse mellan prover tagna 1990, 1994 och 1999 hade en markant sänkning skett av Pb (ca 6% per år), Hg (ca 6% per år) och Cd, men i det fallet bara för män (6% per år), inte för kvinnor. Detta beror sannolikt på minskade utsläpp av dessa metaller, med sjunkande exponering som följd. För Pb och Cd bör sänkningen i exponering ha varit högre än 6% per år, eftersom tidigare ådragen kroppsbörda har en tendens att fördröja en sänkning i blodkroppar. Det finns skäl att även fortsättningsvis följa utvecklingen av metallhalter i blod. För halterna av Al, V, Mn, Co, Ni, Cu, Zn, Se, Rh, Pd, Sb, W och Pt i prover tagna 1999 finns mindre möjligheter att jämföra med andra studier. De funna halterna är emellertid i paritet med det fåtal andra undersökningar som finns. Det fanns en rad associationer mellan halter av olika element. Av särskilt intresse är korrelationerna mellan Pt, Pd and Rh, vilka har spritts i miljön genom användning av katalytiska avgasrenare i bilar. Detta fynd förtjänar vidare undersökningar. Se och Hg var också relaterade, troligen p g a gemensam källa i form av fisk, möjligen också gemensamma bindningar i kroppen.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 15
Typ av publikation
tidskriftsartikel (14)
rapport (1)
Typ av innehåll
refereegranskat (14)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Stegmayr, Birgitta (14)
Johansson, Ingegerd (7)
Weinehall, Lars (7)
Jansson, Jan-Håkan (5)
Skerfving, Staffan (4)
visa fler...
Vessby, Bengt (3)
Nilsson, Torbjörn K (3)
Boman, Kurt (3)
van Guelpen, Bethany (3)
Lundh, Thomas (3)
Winkvist, Anna, 1962 (3)
Hultdin, Johan (3)
Johansson, Lars (2)
Johansson, Anders (2)
Bergdahl, Ingvar A. (2)
Wennberg, Maria, 197 ... (2)
Hallmans, Göran, 194 ... (2)
Wennberg, Maria (2)
Custodio, Hipolito (2)
Rolandsson, Olov (1)
Broberg Palmgren, Ka ... (1)
Johansson, G. (1)
Nilsson, M (1)
Agren, A (1)
Strömberg, Ulf (1)
Lindahl, Bernt (1)
Frostegård, Johan (1)
Palmqvist, Richard (1)
Söderberg, Stefan (1)
de Faire, Ulf (1)
Vikström, Max (1)
Lindahl, B (1)
Marklund, Stefan L. (1)
Wiklund, Per-Gunnar (1)
Eriksson, Marie (1)
Bergdahl, Ingvar (1)
Witthöft, Cornelia M ... (1)
Persson, Mats, 1954 (1)
Nilsson, Lena Maria (1)
Smedman, Annika (1)
Warensjö, Eva (1)
Weinehall, Lars, 194 ... (1)
Jansson, JH (1)
Ekblom, Kim, 1970- (1)
Stegmayr, Birgitta, ... (1)
Fiskesund, Roland (1)
Åhren, Ann-Marie (1)
Öhgren, Bengt (1)
visa färre...
Lärosäte
Umeå universitet (13)
Göteborgs universitet (3)
Lunds universitet (3)
Uppsala universitet (2)
Naturvårdsverket (1)
Karolinska Institutet (1)
Språk
Engelska (14)
Svenska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (7)
Naturvetenskap (1)
Teknik (1)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy