SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Steineck Gunnar) ;hsvcat:1"

Sökning: WFRF:(Steineck Gunnar) > Naturvetenskap

  • Resultat 1-10 av 11
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Biermann, Jana, et al. (författare)
  • A novel 18-marker panel predicting clinical outcome in breast cancer
  • 2017
  • Ingår i: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - 1538-7755. ; 26:11, s. 1619-28
  • Tidskriftsartikel (refereegranskat)abstract
    • Gene expression profiling has made considerable contributions to our understanding of cancer biology and clinical care. This study describes a novel gene expression signature for breast cancer-specific survival that was validated using external datasets. Gene expression signatures for invasive breast carcinomas (mainly Luminal B subtype) corresponding to 136 patients were analysed using Cox regression and the effect of each gene on disease-specific survival (DSS) was estimated. Iterative Bayesian Model Averaging was applied on multivariable Cox regression models resulting in an 18-marker panel, which was validated using three external validation datasets. The 18 genes were analysed for common pathways and functions using the Ingenuity Pathway Analysis software. This study complied with the REMARK criteria. The 18-gene multivariable model showed a high predictive power for DSS in the training and validation cohort and a clear stratification between high- and low-risk patients. The differentially expressed genes were predominantly involved in biological processes such as cell cycle, DNA replication, recombination, and repair. Furthermore, the majority of the 18 genes were found to play a pivotal role in cancer. Our findings demonstrated that the 18 molecular markers were strong predictors of breast cancer-specific mortality. The stable time-dependent area under the ROC curve function (AUC(t)) and high C-indices in the training and validation cohorts were further improved by fitting a combined model consisting of the 18-marker panel and established clinical markers. Our work supports the applicability of this 18-marker panel to improve clinical outcome prediction for breast cancer patients.
  •  
2.
  • Cerna, K., et al. (författare)
  • Changing Categorical Work in Healthcare: the Use of Patient-Generated Health Data in Cancer Rehabilitation
  • 2020
  • Ingår i: Computer Supported Cooperative Work-the Journal of Collaborative Computing and Work Practices. - : Springer Science and Business Media LLC. - 0925-9724. ; 29
  • Tidskriftsartikel (refereegranskat)abstract
    • Categorical work in chronic care is increasingly dependent on digital technologies for remote patient care. However, remote care takes many forms and while various types of digital technologies are currently being used, we lack a nuanced understanding of how to design such technologies for specific novel usages. In this paper, we focus on digital technologies for patient-generated health data and how their use changes categorical work in chronic care. Our aim is to understand how categorical work changes, which novel forms of categorical work emerge and what the implications are for the care relation. This paper is based on an ethnographic study of healthcare professionals' work at a pelvic cancer rehabilitation clinic and their interactions with patients. In this setting, supportive talks between patients and nurses are central. To understand the complexities of categorical work in chronic care when patient-generated health data are introduced, we contrast the traditional supportive talks with supportive talks where the nurses had access to the patients' patient-generated health data. We identify and analyze challenges connected to novel forms of categorical work. Specifically, we focus on categorical work and how it can undergo changes. Our empirical findings show how changes occur in the way patients' lived experience of the chronic disease aligns with the categories from chronic care, as well as in the way the nurse works with clinical categories during the talk. These insights help us further understand the implications of patient generated-data use in supportive talks. We contribute to an improved understanding of the use of patient-generated health data in clinical practice and based on this, we identify design implications for how to make categorical work more collaborative.
  •  
3.
  • Islind, A. S., et al. (författare)
  • Proxy design: a method for involving proxy users to speak on behalf of vulnerable or unreachable users in co-design
  • 2023
  • Ingår i: Information Technology & People. - 0959-3845.
  • Tidskriftsartikel (refereegranskat)abstract
    • PurposeDesigning digital artifacts is not a linear, straightforward process. This is particularly true when applying a user-centered design approach, or co-design, with users who are unable to participate in the design process. Although the reduced participation of a particular user group may harm the end result, the literature on solving this issue is sparse. In this article, proxy design is outlined as a method for involving a user group as proxy users to speak on behalf of a group that is difficult to reach. The article investigates the following research question: How can roleplaying be embedded in co-design to engage users as proxies on behalf of those who are unable to represent themselves?Design/methodology/approachThe article presents a design ethnography spanning three years at a cancer rehabilitation clinic, where digital artifacts were designed to be used collaboratively by nurses and patients. The empirical data were analyzed using content analysis and consisted of 20 observation days at the clinic, six proxy design workshops, 21 telephone consultations between patients and nurses, and log data from the digital artifact.FindingsThe article shows that simulated consultations, with nurses roleplaying as proxies for patients ignited and initiated the design process and enabled an efficient in-depth understanding of patients. Moreover, the article reveals how proxy design as a method further expanded the design. The study findings illustrate: (1) proxy design as a method for initiating design, (2) proxy design as an embedded element in co-design and (3) six design guidelines that should be considered when engaging in proxy design.Originality/valueThe main contribution is the conceptualization of proxy design as a method that can ignite and initiate the co-design process when important users are unreachable, vulnerable or unable to represent themselves in the co-design process. More specifically, based on the empirical findings from a design ethnography that involved nurses as proxy users speaking on behalf of patients, the article shows that roleplaying in proxy design is a fitting way of initiating the design process, outlining proxy design as an embedded element of co-design.
  •  
4.
  • Steineck, Gunnar, 1952, et al. (författare)
  • Identifying radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer survivors
  • 2017
  • Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:2
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2017 Steineck et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: During radiotherapy unwanted radiation to normal tissue surrounding the tumor triggers survivorship diseases; we lack a nosology for radiation-induced survivorship diseases that decrease bowel health and we do not know which symptoms are related to which diseases. Methods: Gynecological-cancer survivors were followed-up two to 15 years after having undergone radiotherapy; they reported in a postal questionnaire the frequency of 28 different symptoms related to bowel health. Population-based controls gave the same information. With a modified factor analysis, we determined the optimal number of factors, factor loadings for each symptom, factor-specific factor-loading cutoffs and factor scores. Results: Altogether data from 623 survivors and 344 population-based controls were analyzed. Six factors best explain the correlation structure of the symptoms; for five of these a statistically significant difference (P< 0.001, Mann-Whitney U test) was found between survivors and controls concerning factor score quantiles. Taken together these five factors explain 42 percent of the variance of the symptoms. We interpreted these five factors as radiation-induced syndromes that may reflect distinct survivorship diseases. We obtained the following frequencies, defined as survivors having a factor loading above the 95 percent percentile of the controls, urgency syndrome (190 of 623, 30 percent), leakage syndrome (164 of 623, 26 percent), excessive gas discharge (93 of 623, 15 percent), excessive mucus discharge (102 of 623, 16 percent) and blood discharge (63 of 623, 10 percent). Conclusion: Late effects of radiotherapy include five syndromes affecting bowel health; studying them and identifying the underlying survivorship diseases, instead of the approximately 30 long-term symptoms they produce, will simplify the search for prevention, alleviation and elimination.
  •  
5.
  • Steineck, Gunnar, et al. (författare)
  • Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment–gynecological cancer survivors
  • 2017
  • Ingår i: Acta Oncologica. - 1651-226X .- 0284-186X. ; 56:5, s. 682-691
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: It is unknown whether smoking; age at time of radiotherapy or time since radiotherapy influence the intensity of late radiation-induced bowel syndromes. Material and methods: We have previously identified 28 symptoms decreasing bowel health among 623 gynecological-cancer survivors (three to twelve years after radiotherapy) and 344 matched population-based controls. The 28 symptoms were grouped into five separate late bowel syndromes through factor analysis. Here, we related possible predictors of bowel health to syndrome intensity, by combining factor analysis weights and symptom frequency on a person-incidence scale. Results: A strong (p
  •  
6.
  • Cerna, Katerina, 1986, et al. (författare)
  • Decision-support System for Cancer Rehabilitation : Designing for Incorporating of Quantified Data into an Existing Practice
  • 2018
  • Ingår i: Proceedings of the 10th Nordic Conference on Human-Computer Interaction. - New York, NY, USA : ACM Publications. - 9781450364379 ; , s. 747-753
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Recent development in self-monitoring devices indicates that using quantified data in clinical practicesupporting chronic diseases management holds a big potential. However, exploration of this design space also suggests that some unattended challenges still exist, such as a low adoption rate of self-monitoring tools in existing clinical practice. In this text, wetherefore focus on the ways healthcare professionalsuse quantified data in their practice. We draw onempirical data from an ethnographic study of a cancer rehabilitation center. Our preliminary findings suggestthat the self-monitoring tool supported the nurses'work because it became a functional complement totheir work by allowing them to appropriate the deviceto their and the patients' needs.
  •  
7.
  • Islind, Anna Sigridur, 1985-, et al. (författare)
  • Shift in translations : Data work with patient-generated health data in clinical practice
  • 2019
  • Ingår i: Health Informatics Journal. - : SAGE Publications. - 1460-4582 .- 1741-2811. ; 25:3, s. 577-586
  • Tidskriftsartikel (refereegranskat)abstract
    • This article reports on how the introduction of patient-generated health data affects the nurses’ and patients’ data work and unpacks how new forms of data collection trigger shifts in the work with data through translation work. The article is based on a 2.5-year case study examining data work of nurses and patients at a cancer rehabilitation clinic at a Swedish Hospital in which patient-generated health data are gathered by patients and then used outside and within clinical practice for decision-making. The article reports on how data are prepared and translated, that is, made useful by the nurses and patients. Using patient-generated health data alters the data work and how the translation of data is performed. The shift in work has three components: (1) a shift in question tactics, (2) a shift in decision-making, and (3) a shift in distribution. The data become mobile, and the data work becomes distributed when using patient-generated health data as an active part of care
  •  
8.
  • Islind, Anna Sigridur, 1985-, et al. (författare)
  • The Virtual Clinic : Two-sided Affordances in Consultation Practice
  • 2019
  • Ingår i: Computer Supported Cooperative Work. - : Springer Science and Business Media LLC. - 0925-9724 .- 1573-7551. ; 28:3-4, s. 435-468
  • Tidskriftsartikel (refereegranskat)abstract
    • Telecare has the potential to increase the quality of care while also decreasing costs. However, despite great potential, efficiency in care practices and cost reduction remain hypothetical. Within computer supported cooperative work (CSCW), one focus of telecare research has been on awareness support in distributed real-time communication in comparison to physical meetings since face-to-face consultations have been known as the “gold standard” of conducting care. Research has shown that it is hard to maintain qualities such as awareness through video-mediated meetings. In this research, the goal has not been to mimic the qualities of face-to-face consultations but rather to document the qualities of three types of patient meetings (consultations) and to understand in what kinds of situations each consultation type is a viable option. In this paper, we focus on the essential qualities of i) face-to-face consultations, ii) video-based consultations, and iii) telephone consultations and shed light on their affordances. The research contribution includes an extension of the affordance lens to incorporate socio-technical, two-sided affordances, that constitute important aspects for understanding complexity when heterogeneous actors co-existing in a practice, where affordances can differ for different “sides” in the complex practice—a view that is fruitful when dealing with heterogeneous actors and a set of analog and digital tools in a practice.
  •  
9.
  • Lindroth, Tomas, 1976-, et al. (författare)
  • From narratives to numbers : Data work and patient-generated health data in consultations
  • 2018
  • Ingår i: Studies in Health Technology and Informatics. - : IOS Press. - 9781614998518 ; , s. 491-495:247, s. 491-495
  • Konferensbidrag (refereegranskat)abstract
    • This article presents preliminary findings on how the introduction of patient-generated health data (PGHD) triggers changes during patient-nurse consultations. This article builds on a two-year case study, examining the work practice at a cancer rehabilitation clinic at a Swedish Hospital using PGHD. The study focuses on how nurses’ use data, gathered by patients with a mobile phone app, during consultations. The use of PGHD introduce a change in the translation work, the work of turning rich patient descriptions and transform them into data, during the consultation for documentation and clinical decision-making. This change affects precision, questions asked and the use of visualizations as well as the patient-nurse decision making. © 2018 European Federation for Medical Informatics (EFMI) and IOS Press.
  •  
10.
  • Malipatlolla, Dilip, 1990, et al. (författare)
  • A fiber-rich diet and radiation-induced injury in the murine intestinal mucosa
  • 2022
  • Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Dietary fiber is considered a strong intestinal protector, but we do not know whether dietary fiber protects against the long-lasting mucosal damage caused by ionizing radiation. To evaluate whether a fiber-rich diet can ameliorate the long-lasting pathophysiological hallmarks of the irradiated mucosa, C57BL/6J mice on a fiber-rich bioprocessed oat bran diet or a fiber-free diet received 32 Gray in four fractions to the distal colorectum using a linear accelerator and continued on the diets for one, six or 18 weeks. We quantified degenerating crypts, crypt fission, cell proliferation, crypt survival, macrophage density and bacterial infiltration. Crypt loss through crypt degeneration only occurred in the irradiated mice. Initially, it was most frequent in the fiber-deprived group but declined to levels similar to the fiber-consuming group by 18 weeks. The fiber-consuming group had a fast response to irradiation, with crypt fission for growth or healing peaking already at one week post-irradiation, while crypt fission in the fiber-deprived group peaked at six weeks. A fiber-rich diet allowed for a more intense crypt cell proliferation, but the recovery of crypts was eventually lost by 18 weeks. Bacterial infiltration was a late phenomenon, evident in the fiber-deprived animals and intensified manyfold after irradiation. Bacterial infiltration also coincided with a specific proinflammatory serum cytokine profile. In contrast, mice on a fiber-rich diet were completely protected from irradiation-induced bacterial infiltration and exhibited a similar serum cytokine profile as sham-irradiated mice on a fiber-rich diet. Our findings provide ample evidence that dietary fiber consumption modifies the onset, timing and intensity of radiation-induced pathophysiological processes in the intestinal mucosa. However, we need more knowledge, not least from clinical studies, before this finding can be introduced to a new and refined clinical practice.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 11
Typ av publikation
tidskriftsartikel (9)
konferensbidrag (2)
Typ av innehåll
refereegranskat (10)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Steineck, Gunnar, 19 ... (10)
Lundin, Johan, 1975 (6)
Lindroth, Tomas, 197 ... (5)
Islind, Anna Sigridu ... (4)
Sjöberg, Fei (3)
Jörnsten, Rebecka, 1 ... (2)
visa fler...
Helou, Khalil, 1966 (2)
Alevronta, Eleftheri ... (2)
Skokic, Viktor, 1982 (2)
Bull, Cecilia, 1977 (2)
Dunberger, Gail (2)
Wilderäng, Ulrica (2)
Nemes, Szilard, 1977 (2)
Islind, A. S. (2)
Parris, Toshima Z, 1 ... (2)
Cerna, K. (2)
Cerna, Katerina, 198 ... (2)
Karlsson, Per, 1963 (1)
Danielsson, Anna, 19 ... (1)
Forssell-Aronsson, E ... (1)
Bergmark, Karin, 196 ... (1)
Devarakonda, Sravani (1)
Miao Jonasson, Junme ... (1)
Johansson, Malin E V ... (1)
Nyman, Margareta (1)
Rascon, Ana (1)
Kalm, Marie, 1981 (1)
Einbeigi, Zakaria, 1 ... (1)
Lundh Snis, Ulrika, ... (1)
Bergmark, Karin (1)
Steineck, Gunnar (1)
Biermann, Jana (1)
Engqvist, Hanna, 198 ... (1)
Werner Rönnerman, El ... (1)
Grandér, Rita (1)
Danial, Jolie (1)
Malipatlolla, Dilip, ... (1)
Grisot, M. (1)
Patel, Piyush (1)
Stringer, Andrea (1)
Akeflo, L. (1)
Mehdin, Eva (1)
Warholm, Malin (1)
Norling, Henrietta (1)
Oh, Jung Hun (1)
Deasy, Joseph O. (1)
Skokic, Viktor (1)
Bull, Cecilia (1)
visa färre...
Lärosäte
Göteborgs universitet (10)
Högskolan Väst (4)
Karolinska Institutet (3)
Lunds universitet (1)
Chalmers tekniska högskola (1)
Språk
Engelska (11)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (7)
Teknik (2)
Samhällsvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy