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Search: WFRF:(Stolzenberg Solomon Rachael Z) > (2009) > Chanock Stephen J > Genome-wide associa...

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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

Amundadottir, Laufey (author)
Kraft, Peter (author)
Stolzenberg-Solomon, Rachael Z (author)
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Fuchs, Charles S (author)
Petersen, Gloria M (author)
Arslan, Alan A (author)
Bueno-de-Mesquita, H Bas (author)
Gross, Myron (author)
Helzlsouer, Kathy (author)
Jacobs, Eric J (author)
Lacroix, Andrea (author)
Zheng, Wei (author)
Albanes, Demetrius (author)
Bamlet, William (author)
Berg, Christine D (author)
Berrino, Franco (author)
Bingham, Sheila (author)
Buring, Julie E (author)
Bracci, Paige M (author)
Canzian, Federico (author)
Clavel-Chapelon, Françoise (author)
Clipp, Sandra (author)
Cotterchio, Michelle (author)
de Andrade, Mariza (author)
Duell, Eric J (author)
Fox Jr, John W (author)
Gallinger, Steven (author)
Gaziano, J Michael (author)
Giovannucci, Edward L (author)
Goggins, Michael (author)
González, Carlos A (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Hankinson, Susan E (author)
Hassan, Manal (author)
Holly, Elizabeth A (author)
Hunter, David J (author)
Hutchinson, Amy (author)
Jackson, Rebecca (author)
Jacobs, Kevin B (author)
Jenab, Mazda (author)
Kaaks, Rudolf (author)
Klein, Alison P (author)
Kooperberg, Charles (author)
Kurtz, Robert C (author)
Li, Donghui (author)
Lynch, Shannon M (author)
Mandelson, Margaret (author)
McWilliams, Robert R (author)
Mendelsohn, Julie B (author)
Michaud, Dominique S (author)
Olson, Sara H (author)
Overvad, Kim (author)
Patel, Alpa V (author)
Peeters, Petra H M (author)
Rajkovic, Aleksandar (author)
Riboli, Elio (author)
Risch, Harvey A (author)
Shu, Xiao-Ou (author)
Thomas, Gilles (author)
Tobias, Geoffrey S (author)
Trichopoulos, Dimitrios (author)
Van Den Eeden, Stephen K (author)
Virtamo, Jarmo (author)
Wactawski-Wende, Jean (author)
Wolpin, Brian M (author)
Yu, Herbert (author)
Yu, Kai (author)
Zeleniuch-Jacquotte, Anne (author)
Chanock, Stephen J (author)
Hartge, Patricia (author)
Hoover, Robert N (author)
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 (creator_code:org_t)
2009-08-02
2009
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41, s. 986-990
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

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