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| 2. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 4. |
- Roger, Ström, 1963-, et al.
(författare)
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Mobile marketing: A literature review on its value for consumers and retailers
- 2014
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Ingår i: Journal of Retailing and Consumer Services. - Oxford : Elsevier. - 0969-6989 .- 1873-1384. ; 21, s. 1001-1012
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Tidskriftsartikel (refereegranskat)abstract
- The article describes the existing knowledge of how mobile marketing can increase the value for consumers and retailers. Mobile device shopping, and consumers0 use of mobile devices while shopping is shown to be both an extension of consumers0 shopping behaviours developed on Internet-connected desktop and laptop computers (PC), and potentially new behaviours based on a mobile devices0 uniquely integrated features such as camera, scanners and GPS. The article focuses on how mobile marketing creates value for consumers and retailers, enabling more precise research and development of manage- rial concepts and tools while providing both managers and academics with increased understanding of mobile marketing and its value outcomes for retailers.
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| 5. |
- Ström, Patrik, 1976, et al.
(författare)
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Space Oddity – On Managerial Decision Making and Space.
- 2010
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Ingår i: Paper for the 1st International Symposium on Management Geography, Spaces of International Economy and Management, Kyoto, March 24-25.
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Konferensbidrag (refereegranskat)
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| 6. |
- Ström, Patrik, 1976, et al.
(författare)
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Space Oddity – On Managerial Decision Making and Space
- 2011
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Ingår i: Spaces of International Economy and Management Launching New Perspectives on Management and Geography. - Basingstoke : Palgrave Macmillan. ; , s. 304-314
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Ström, Roger, 1963-, et al.
(författare)
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The value of mobile marketing for consumers and retailers : a literature review
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Purpose: In this review mobile device shopping, consumers' use of mobile devices while shopping, is assumed to be an extension of consumers' shopping behaviors developed on internet connected desktop and laptop computers (PC). The purpose is to describe existing knowledge on how mobile marketing can increase value for consumers and retailers, enabling more precise research and development of managerial concepts and tools, providing both managers and academics with increased understanding of mobile marketing and it's outcome value for retailers.Methodology/Approach: The review is based on a qualitative content analysis of 64 selected peer-reviewed articles presenting empirical results. The results are categorized based on research themes, and then discussed within and between categories.Findings: Mobile marketing increases perceived value for consumers and outcome value for retailers. But only limited support is found supporting mobile marketing as more effective than retailers' alternative marketing investments. Indications of increased outcome value of retailers' existing marketing investments are found by the effects of mobile channel addition and integration. The path between consumer perceived value and retailers' outcome value is indicated, but not verified. The existing knowledge regarding mobile device shoppers, consumers using mobile devices for shopping and potentially being valuable segments for retailers, is limited to their interactions with mobile advertising and use of mobile retail services. Mobile marketing delivers multiple perceived values to consumers (utilitarian, emotional/ entertainment/ hedonic and social values), and relative benefits and values of mobile devices (enjoyable, timely and offered companionship) and marketing (efficiency, time and location convenience) compared to PC internet. These values may be perceived differently depending on shopping context. For consumers and retailers to leverage the full potentials of mobile marketing, integrations with entire consumer interfaces may be needed, implying development of partner network and structural bonds within partner networks, structural changes of IT-structure and organizations, potentially resulting in foundations for sustainable competitive advantages.Research Implications/Limitations: Abilities to generalize results from this review are affected by the limited numbers of selected studies. Results from other industries are generalized as valid for retailing, while results of mobile advertising applications in some cases are generalized as valid for other mobile marketing application areas.Originality/Value/Contribution: The review describes the value of mobile marketing in a consumer retail context, discussing less studied mobile marketing application areas, support for physical service interactions in-store and post-purchase interactions, highlighting potentials of mobile marketing integration with entire consumer interfaces, and suggesting a holistic approach studying users of mobile devices, services and marketing. Managerial implications and implications for further research are presented.
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