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Sex-Specific Effect...
Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
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- Persson, Jonas (author)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.
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- Strawbridge, Rona J. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
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- McLeod, Olga (author)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden
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- Gertow, Karl (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.
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- Silveira, Angela (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
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- Baldassarre, Damiano (author)
- Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy
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- Van Zuydam, Natalie (author)
- Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland
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- Shah, Sonia (author)
- UCL, Genet Inst, London, England.;Univ Queensland, Diamantina Inst, Brisbane, Qld 4072, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.,UCL, England; University of Queensland, Australia; University of Queensland, Australia
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- Fava, Cristiano (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden; University of Verona, Italy,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.;Univ Verona, Hosp Policlin GB Rossi, Dept Med, Div Internal Med C, I-37100 Verona, Italy.
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden
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- Veglia, Fabrizio (author)
- Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy
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- Sennblad, Bengt (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, Stockholm, Sweden.
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- Larsson, Malin (author)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten,Linkoping Univ, IFM Bioinformat, Linkoping, Sweden.
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- Sabater-Lleal, Maria (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
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- Leander, Karin (author)
- Karolinska Institutet
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- Gigante, Bruna (author)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.
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- Tabak, Adam (author)
- Semmelweis Univ, Fac Med, Dept Med 1, H-1085 Budapest, Hungary.,Semmelweis University, Hungary
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- Kivimaki, Mika (author)
- UCL, Dept Epidemiol & Publ Hlth, London, England.
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- Kauhanen, Jussi (author)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.,University of Eastern Finland, Finland
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- Rauramaa, Rainer (author)
- Kuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.,Kuopio Research Institute Exercise Med, Finland; Kuopio University Hospital, Finland
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- Smit, Andries J. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Med, NL-9700 AB Groningen, Netherlands.,University of Groningen, Netherlands
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- Mannarino, Elmo (author)
- Univ Perugia, Dept Clin & Expt Med, Internal Med Angiol & Arteriosclerosis Dis, I-06100 Perugia, Italy.,University of Perugia, Italy
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- Giral, Philippe (author)
- Grp Hosp Pitie Salpetriere, AP HP, Serv Endocrinol Metab, Unites Prevent Cardiovasc, F-75634 Paris, France.,Grp Hospital Pitie Salpetriere, France
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- Humphries, Steve E. (author)
- UCL, Ctr Cardiovasc Genet, London, England.
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- Tremoli, Elena (author)
- Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy
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- de Faire, Ulf (author)
- Karolinska Institutet,Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Sweden
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden
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- Hedblad, Bo (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.
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- Kumari, Meena (author)
- UCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England.
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- Hingorani, Aroon (author)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;UCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England.,Karolinska Institute, Sweden; UCL, England
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- Morris, Andrew D. (author)
- Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland
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- Palmer, Colin N. A. (author)
- Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland
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- Lundman, Pia (author)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.
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- Ohrvik, John (author)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden
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- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi,Umea Univ, Dept Publ Hlth & Clin Med, Div Med, S-90187 Umea, Sweden.
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Hamsten, Anders (author)
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Karolinska Institutet Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden (creator_code:org_t)
- WILEY-BLACKWELL, 2015
- 2015
- English.
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In: Journal of the American Heart Association. - : WILEY-BLACKWELL. - 2047-9980. ; 4:8
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Abstract
Subject headings
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- Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Methods and Results-Baseline plasma adiponectin concentrationwas tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (beta=-0.018, P<0.001) in men but not in women (beta=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (beta=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82,95% CI0.54 to 1.25). Agenescore of adiponectin-raisingalleles in6loci, reported recently inalarge multi-ethnic metaanalysis, was inversely associated with baseline mean bifurcation IMT in men (beta=-0.0008, P=0.004) but not in women (beta=-0.0003, P=0.522; P for interaction=0.007). Conclusions-This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- adiponectin
- atherosclerosis
- carotid intima-media thickness
- genetics
- Mendelian randomization
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Persson, Jonas
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Strawbridge, Ron ...
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McLeod, Olga
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Gertow, Karl
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Silveira, Angela
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Baldassarre, Dam ...
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show more...
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Van Zuydam, Nata ...
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Shah, Sonia
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Fava, Cristiano
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Gustafsson, Stef ...
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Veglia, Fabrizio
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Sennblad, Bengt
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Larsson, Malin
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Sabater-Lleal, M ...
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Leander, Karin
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Gigante, Bruna
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Tabak, Adam
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Kivimaki, Mika
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Kauhanen, Jussi
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Rauramaa, Rainer
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Smit, Andries J.
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Mannarino, Elmo
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Giral, Philippe
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Humphries, Steve ...
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Tremoli, Elena
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de Faire, Ulf
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Lind, Lars
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Ingelsson, Erik
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Hedblad, Bo
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Melander, Olle
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Kumari, Meena
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Hingorani, Aroon
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Morris, Andrew D ...
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Palmer, Colin N. ...
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Lundman, Pia
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Ohrvik, John
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Söderberg, Stefa ...
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Hamsten, Anders
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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Journal of the A ...
- By the university
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet
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Umeå University