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A candidate gene st...
A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
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- Sandling, Johanna K. (author)
- Uppsala universitet,Molekylär medicin
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- Garnier, Sophie (author)
- Uppsala universitet,Molekylär medicin
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- Sigurdsson, Snaevar (author)
- Uppsala universitet,Molekylär medicin
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- Wang, Chuan (author)
- Uppsala universitet,Molekylär medicin
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- Nordmark, Gunnel (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Systemic Autoimmunity
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- Gunnarsson, Iva (author)
- Karolinska Institutet
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- Svenungsson, Elisabet (author)
- Karolinska Institutet
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- Padyukov, Leonid (author)
- Karolinska Institutet
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- Sturfelt, Gunnar (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Bengtsson, Anders (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Truedsson, Lennart (author)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine
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- Eriksson, Catharina, 1955- (author)
- Umeå universitet,Klinisk immunologi
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- Rantapää-Dahlqvist, Solbritt (author)
- Umeå universitet,Reumatologi
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- Mälarstig, Anders (author)
- Karolinska Institutet
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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- Hamsten, Anders (author)
- Karolinska Institutet
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Criswell, Lindsey A. (author)
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Graham, Robert R. (author)
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Behrens, Timothy W. (author)
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- Eloranta, Maija-Leena (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Systemic Autoimmunity
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- Alm, Gunnar (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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- Rönnblom, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Systemic Autoimmunity
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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(creator_code:org_t)
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- 2010-12-22
- 2011
- English.
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In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 19:4, s. 479-484
- Related links:
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https://www.nature.c...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://res.slu.se/i...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease in which the type I interferon pathway has a crucial role. We have previously shown that three genes in this pathway, IRF5, TYK2 and STAT4, are strongly associated with risk for SLE. Here, we investigated 78 genes involved in the type I interferon pathway to identify additional SLE susceptibility loci. First, we genotyped 896 single-nucleotide polymorphisms in these 78 genes and 14 other candidate genes in 482 Swedish SLE patients and 536 controls. Genes with P<0.01 in the initial screen were then followed up in 344 additional Swedish patients and 1299 controls. SNPs in the IKBKE, TANK, STAT1, IL8 and TRAF6 genes gave nominal signals of association with SLE in this extended Swedish cohort. To replicate these findings we extracted data from a genomewide association study on SLE performed in a US cohort. Combined analysis of the Swedish and US data, comprising a total of 2136 cases and 9694 controls, implicates IKBKE and IL8 as SLE susceptibility loci (P(meta)=0.00010 and P(meta)=0.00040, respectively). STAT1 was also associated with SLE in this cohort (P(meta)=3.3 × 10(-5)), but this association signal appears to be dependent of that previously reported for the neighbouring STAT4 gene. Our study suggests additional genes from the type I interferon system in SLE, and highlights genes in this pathway for further functional analysis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- systemic lupus erythematosus
- type I interferon system
- candidate gene study
- single nucleotide polymorphism
- IKBKE
- IL8
- MEDICINE
- MEDICIN
- Medicin
- Medicine
- systemic lupus erythematosus
- type I interferon system
- candidate gene
- study
- single nucleotide polymorphism
- IKBKE
- IL8
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Sandling, Johann ...
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Garnier, Sophie
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Sigurdsson, Snae ...
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Wang, Chuan
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Nordmark, Gunnel
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Gunnarsson, Iva
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show more...
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Svenungsson, Eli ...
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Padyukov, Leonid
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Sturfelt, Gunnar
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Jönsen, Andreas
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Bengtsson, Ander ...
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Truedsson, Lenna ...
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Eriksson, Cathar ...
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Rantapää-Dahlqvi ...
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Mälarstig, Ander ...
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Strawbridge, Ron ...
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Hamsten, Anders
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Criswell, Lindse ...
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Graham, Robert R ...
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Behrens, Timothy ...
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Eloranta, Maija- ...
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Alm, Gunnar
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Rönnblom, Lars
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Syvänen, Ann-Chr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University
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Lund University
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Swedish University of Agricultural Sciences
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Umeå University
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Karolinska Institutet