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A common coding var...
A common coding variant in CASP8 is associated with breast cancer risk
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Cox, Angela (author)
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Dunning, Alison M. (author)
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Garcia-Closas, Montserrat (author)
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show more...
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Balasubramanian, Sabapathy (author)
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Reed, Malcolm W. R. (author)
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Pooley, Karen A. (author)
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- Scollen, Serena (author)
- Karolinska Institutet
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Baynes, Caroline (author)
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Ponder, Bruce A. J. (author)
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Chanock, Stephen (author)
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Lissowska, Jolanta (author)
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Brinton, Louise (author)
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Peplonska, Beata (author)
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Southey, Melissa C. (author)
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Hopper, John L. (author)
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McCredie, Margaret R. E. (author)
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Giles, Graham G. (author)
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Fletcher, Olivia (author)
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Johnson, Nichola (author)
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dos Santos Silva, Isabel (author)
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Gibson, Lorna (author)
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Bojesen, Stig E. (author)
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Nordestgaard, Børge G. (author)
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Axelsson, Christen K. (author)
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Torres, Diana (author)
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Hamann, Ute (author)
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Justenhoven, Christina (author)
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Brauch, Hiltrud (author)
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Chang-Claude, Jenny (author)
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Kropp, Silke (author)
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Risch, Angela (author)
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Wang-Gohrke, Shan (author)
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Schürmann, Peter (author)
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Bogdanova, Natalia (author)
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Dörk, Thilo (author)
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Fagerholm, Rainer (author)
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Aaltonen, Kirsimari (author)
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- Blomqvist, Carl (author)
- Uppsala universitet,Enheten för onkologi
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Nevanlinna, Heli (author)
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Seal, Sheila (author)
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Renwick, Anthony (author)
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Stratton, Michael R. (author)
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Rahman, Nazneen (author)
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Sangrajrang, Suleeporn (author)
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Hughes, David (author)
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Odefrey, Fabrice (author)
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Brennan, Paul (author)
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Spurdle, Amanda B. (author)
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Chenevix-Trench, Georgia (author)
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Beesley, Jonathan (author)
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Mannermaa, Arto (author)
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Hartikainen, Jaana (author)
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Kataja, Vesa (author)
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Kosma, Veli-Matti (author)
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Couch, Fergus J. (author)
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Olson, Janet E. (author)
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Goode, Ellen L. (author)
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Broeks, Annegien (author)
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Schmidt, Marjanka K. (author)
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Hogervorst, Frans B. L. (author)
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Van't Veer, Laura J. (author)
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Kang, Daehee (author)
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Yoo, Keun-Young (author)
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Noh, Dong-Young (author)
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Ahn, Sei-Hyun (author)
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Wedrén, Sara (author)
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- Hall, Per (author)
- Karolinska Institutet
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Low, Yen-Ling (author)
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Liu, Jianjun (author)
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Milne, Roger L (author)
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Ribas, Gloria (author)
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Gonzalez-Neira, Anna (author)
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Benitez, Javier (author)
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Sigurdson, Alice J. (author)
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Stredrick, Denise L. (author)
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Alexander, Bruce H. (author)
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Struewing, Jeffery P. (author)
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Pharoah, Paul D. P. (author)
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Easton, Douglas F. (author)
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(creator_code:org_t)
- 2007-02-11
- 2007
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:3, s. 352-358
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.
Keyword
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- MEDICIN
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- By the author/editor
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Cox, Angela
-
Dunning, Alison ...
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Garcia-Closas, M ...
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Balasubramanian, ...
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Reed, Malcolm W. ...
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Pooley, Karen A.
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show more...
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Scollen, Serena
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Baynes, Caroline
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Ponder, Bruce A. ...
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Chanock, Stephen
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Lissowska, Jolan ...
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Brinton, Louise
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Peplonska, Beata
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Southey, Melissa ...
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Hopper, John L.
-
McCredie, Margar ...
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Giles, Graham G.
-
Fletcher, Olivia
-
Johnson, Nichola
-
dos Santos Silva ...
-
Gibson, Lorna
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Bojesen, Stig E.
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Nordestgaard, Bø ...
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Axelsson, Christ ...
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Torres, Diana
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Hamann, Ute
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Justenhoven, Chr ...
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Brauch, Hiltrud
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Chang-Claude, Je ...
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Kropp, Silke
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Risch, Angela
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Wang-Gohrke, Sha ...
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Schürmann, Peter
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Bogdanova, Natal ...
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Dörk, Thilo
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Fagerholm, Raine ...
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Aaltonen, Kirsim ...
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Blomqvist, Carl
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Nevanlinna, Heli
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Seal, Sheila
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Renwick, Anthony
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Stratton, Michae ...
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Rahman, Nazneen
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Sangrajrang, Sul ...
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Hughes, David
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Odefrey, Fabrice
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Brennan, Paul
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Spurdle, Amanda ...
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Chenevix-Trench, ...
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Beesley, Jonatha ...
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Mannermaa, Arto
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Hartikainen, Jaa ...
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Kataja, Vesa
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Kosma, Veli-Matt ...
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Couch, Fergus J.
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Olson, Janet E.
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Goode, Ellen L.
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Broeks, Annegien
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Schmidt, Marjank ...
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Hogervorst, Fran ...
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Van't Veer, Laur ...
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Kang, Daehee
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Yoo, Keun-Young
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Noh, Dong-Young
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Ahn, Sei-Hyun
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Wedrén, Sara
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Hall, Per
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Low, Yen-Ling
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Liu, Jianjun
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Milne, Roger L
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Ribas, Gloria
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Gonzalez-Neira, ...
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Benitez, Javier
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Sigurdson, Alice ...
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Stredrick, Denis ...
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Alexander, Bruce ...
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Struewing, Jeffe ...
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Pharoah, Paul D. ...
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Easton, Douglas ...
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- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Karolinska Institutet