↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Stumvoll M) ;lar1:(ki)"

Search: WFRF:(Stumvoll M) > Karolinska Institutet

Result 1-10 of 56

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Winkler, TW, et al. (author) Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals 2022 In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 580- Journal article (peer-reviewed)abstract Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
2.	Winkler, TW, et al. (author) Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 2016 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 12:6, s. e1006166- Journal article (peer-reviewed)
3.	Winkler, TW, et al. (author) The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 2015 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 11:10, s. e1005378- Journal article (peer-reviewed)
4.	Wood, AR, et al. (author) Defining the role of common variation in the genomic and biological architecture of adult human height 2014 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:11, s. 1173-1186 Journal article (peer-reviewed)
5.	Chen, J, et al. (author) The trans-ancestral genomic architecture of glycemic traits 2021 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 53:6, s. 840- Journal article (peer-reviewed)
6.	Locke, Adam E, et al. (author) Genetic studies of body mass index yield new insights for obesity biology. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Journal article (peer-reviewed)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
7.	Linner, RK, et al. (author) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:2, s. 245- Journal article (peer-reviewed)
8.	Tin, A, et al. (author) Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:10, s. 1459- Journal article (peer-reviewed)
9.	Shungin, Dmitry, et al. (author) New genetic loci link adipose and insulin biology to body fat distribution. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378 Journal article (peer-reviewed)abstract Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
10.	Dupuis, J, et al. (author) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk 2010 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:2, s. 105-U32 Journal article (peer-reviewed)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-10 of 56

Refine your search

Type of publication: journal article (51); conference paper (5)

Type of content: peer-reviewed (51); other academic/artistic (5)

Author/Editor: Stumvoll, M. (36); Kovacs, P (23); Tonjes, A (20); Groop, Leif (19); Boehnke, Michael (19); Prokopenko, Inga (19); show more...; Lind, Lars (18); Wareham, Nicholas J. (18); McCarthy, Mark I (18); Jackson, Anne U. (18); Kovacs, Peter (17); Loos, Ruth J F (17); Kuusisto, Johanna (16); Laakso, Markku (16); Mohlke, Karen L (16); Bluher, M. (16); Ingelsson, Erik (15); Tuomilehto, Jaakko (15); Barroso, Ines (15); Froguel, Philippe (15); Luan, Jian'an (15); Wilson, James F. (15); Lyssenko, Valeriya (14); Salomaa, Veikko (14); Campbell, Harry (14); Rudan, Igor (14); Ohlsson, Claes, 1965 (14); van Duijn, Cornelia ... (14); Langenberg, Claudia (14); Thorleifsson, Gudmar (14); Stefansson, Kari (14); Gieger, Christian (14); Metspalu, Andres (14); Psaty, BM (13); Wilson, JF (13); Perola, M. (13); Hayward, Caroline (13); Boerwinkle, Eric (13); Esko, Tõnu (13); Perola, Markus (12); Teumer, A (12); Lehtimaki, T. (12); Hamsten, Anders (12); Campbell, H (12); Gustafsson, Stefan (12); Pramstaller, Peter P ... (12); Hayward, C. (12); Rudan, I. (12); Rivadeneira, Fernand ... (12); Hofman, Albert (12); show less...

University: Karolinska Institutet (56)Undo refine; Uppsala University (30); Lund University (25); University of Gothenburg (16); Umeå University (15); Högskolan Dalarna (7); show more...; Stockholm University (2); Stockholm School of Economics (2); Luleå University of Technology (1); show less...

Language: English (56)

Research subject (UKÄ/SCB): Medical and Health Sciences (33); Natural sciences (6)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view