| 1. |
- Byrnes, Andrea, et al.
(författare)
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Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue : no evidence of a biomarker
- 2009
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 4:6, s. e5805-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes. METHODS: Cases were 44 individuals who were clinically evaluated and found to meet standard international criteria for chronic fatigue syndrome or idiopathic chronic fatigue, and controls were their monozygotic co-twins who were clinically evaluated and never had even one month of impairing fatigue. Biological sampling conditions were standardized and RNA stabilizing media were used. These methodological features provide rigorous control for bias resulting from case-control mismatched ancestry and experimental error. Individual gene expression profiles were assessed using Affymetrix Human Genome U133 Plus 2.0 arrays. FINDINGS: There were no significant differences in gene expression for any transcript. CONCLUSIONS: Contrary to our expectations, we were unable to identify a biomarker for chronic fatiguing illness in the transcriptome of peripheral blood leukocytes suggesting that positive findings in prior studies may have resulted from experimental bias.
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| 2. |
- Evengård, Birgitta, 1952-, et al.
(författare)
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The epidemiology of chronic fatigue in the Swedish Twin Registry
- 2005
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Ingår i: Psychological Medicine. - 0033-2917 .- 1469-8978. ; 35:9, s. 1317-1326
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Tidskriftsartikel (refereegranskat)abstract
- CFS-like illness may be more common that previously acknowledged. There is a marked increase in risk by gender. Previous reports that CFS is more prevalent in individuals in certain occupational categories were not confirmed and may have been due to confounding by gender.
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| 3. |
- Forlenza, Michael J, et al.
(författare)
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Epidemiology of cancer-related fatigue in the Swedish twin registry
- 2005
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Ingår i: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 104:9, s. 2022-2031
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Tidskriftsartikel (refereegranskat)abstract
- A greater proportion of individuals who were listed in a national cancer registry reported experiencing fatigue compared with individuals in the general population.
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| 4. |
- Kato, K, et al.
(författare)
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A population-based twin study of functional somatic syndromes
- 2009
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Ingår i: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 39:3, s. 497-505
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The mechanisms underlying the co-occurrence of the functional somatic syndromes are largely unknown. No empirical study has explicitly examined how genetic and environmental factors influence the co-morbidity of these syndromes. We aimed to examine how the co-morbidity of functional somatic syndromes is influenced by genetic and environmental factors that are in common to the syndromes. METHOD: A total of 31318 twins in the Swedish Twin Registry aged 41-64 years underwent screening interviews via a computer-assisted telephone system from 1998 to 2002. Four functional somatic syndromes (chronic widespread pain, chronic fatigue, irritable bowel syndrome, and recurrent headache) and two psychiatric disorders (major depression and generalized anxiety disorder) were assessed using structured questions based on standard criteria for each illness in a blinded manner. RESULTS: Multivariate twin analyses revealed that a common pathway model with two latent traits that were shared by the six illnesses fit best to the women's data. One of the two latent traits loaded heavily on the psychiatric disorders, whereas the other trait loaded on all four of the functional somatic syndromes, particularly chronic widespread pain, but not on the psychiatric disorders. All illnesses except the psychiatric disorders were also affected by genetic influences that were specific to each. CONCLUSIONS: The co-occurrence of functional somatic syndromes in women can be best explained by affective and sensory components in common to all these syndromes, as well as by unique influences specific to each of them. The findings clearly suggest a complex view of the multifactorial pathogenesis of these illnesses.
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| 5. |
- Kato, Kenji, et al.
(författare)
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Chronic widespread pain and its comorbidities : a population-based study
- 2006
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Ingår i: Archives of Internal Medicine. - : American Medical Association (AMA). - 0003-9926 .- 1538-3679. ; 166:15, s. 1649-1654
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Tidskriftsartikel (refereegranskat)abstract
- Associations between CWP and most comorbidities are mediated by unmeasured genetic and family environmental factors in the general population. The extent of mediation via familial factors is likely to be disorder specific.
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| 6. |
- Kato, Kenji, et al.
(författare)
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Importance of genetic influences on chronic widespread pain
- 2006
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 54:5, s. 1682-1686
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Tidskriftsartikel (refereegranskat)abstract
- Individual differences in the likelihood of developing chronic widespread pain reflect modest genetic influences. There are no significant sex differences in the type or expression of the genes responsible for chronic widespread pain or in the magnitude of the relative importance of these influences on chronic widespread pain.
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| 7. |
- Kato, Kenji, et al.
(författare)
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Premorbid predictors of chronic fatigue
- 2006
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Ingår i: Archives of General Psychiatry. - : American Medical Association (AMA). - 0003-990X .- 1538-3636. ; 63:11, s. 1267-1272
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Tidskriftsartikel (refereegranskat)abstract
- Elevated premorbid stress is a significant risk factor for chronic fatigue-like illness, the effect of which may be buffered by genetic influences. Emotional instability assessed 25 years earlier is associated with chronic fatigue through genetic mechanisms contributing to both personality style and expression of the disorder. These findings suggest plausible mechanisms for chronic fatiguing illness.
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| 8. |
- Sullivan, Patrick F, et al.
(författare)
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An unbiased metagenomic search for infectious agents using monozygotic twins discordantfor chronic fatigue
- 2011
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Ingår i: BMC Microbiology. - : BMC. - 1471-2180. ; 11:2
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Tidskriftsartikel (refereegranskat)abstract
- Background: Chronic fatigue syndrome is an idiopathic syndrome widely suspected of having an infectious orimmune etiology. We applied an unbiased metagenomic approach to try to identify known or novel infectiousagents in the serum of 45 cases with chronic fatigue syndrome or idiopathic chronic fatigue. Controls were theunaffected monozygotic co-twins of cases, and serum samples were obtained at the same place and time.Results: No novel DNA or RNA viral signatures were confidently identified. Four affected twins and no unaffectedtwins evidenced viremia with GB virus C (8.9% vs. 0%, p = 0.019), and one affected twin had previously undetectedhepatitis C viremia. An excess of GB virus C viremia in cases with chronic fatigue requires confirmation.Conclusions: Current, impairing chronic fatigue was not robustly associated with viremia detectable in serum.
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| 9. |
- Sullivan, Patrick F, et al.
(författare)
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Chronic fatigue in a population sample : definitions and heterogeneity
- 2005
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Ingår i: Psychological Medicine. - 0033-2917 .- 1469-8978. ; 35:9, s. 1337-1348
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Tidskriftsartikel (refereegranskat)abstract
- Our data are consistent with the 'existence' of CFS-like illness although the dominant nosological approach captures population-level variation poorly. We suggest that studying a more parsimonious case definition - impairing chronic fatigue not due to a known cause - would represent a way forward.
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| 10. |
- Sullivan, Patrick F, et al.
(författare)
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Twin analyses of chronic fatigue in a Swedish national sample
- 2005
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Ingår i: Psychological Medicine. - 0033-2917 .- 1469-8978. ; 35:9, s. 1327-1336
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Tidskriftsartikel (refereegranskat)abstract
- Current fatiguing illness appears to be a complex trait resulting from both environmental and genetic sources of variation without pronounced differences by gender.
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