| 1. |
- Holmgren, Jan, 1944, et al.
(författare)
-
Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA
- 2005
-
Ingår i: Immunology Letters. - : Elsevier. - 0165-2478 .- 1879-0542. ; 97:2, s. 181-8
-
Tidskriftsartikel (refereegranskat)abstract
- Mucosal immunisation may be used both to protect the mucosal surfaces against infections and as a means for immunological treatment of peripheral immunopathological disorders through the induction of systemic antigen-specific tolerance ('oral tolerance'). The development of mucosal vaccines, whether for prevention of infectious diseases or for oral tolerance immunotherapy, requires efficient antigen delivery and adjuvant systems that can help to present the appropriate vaccine or immunotherapy antigens to the mucosal immune system. The most potent (but also toxic) mucosal adjuvants are cholera toxin (CT) and the closely related Escherichia coli heat-labile enterotoxin (LT), and much effort and significant progress have been made recently to generate toxicologically acceptable derivatives of these toxins with retained adjuvant activity. Among these are the non-toxic, recombinantly produced cholera toxin B-subunit (CTB). CTB is a specific protective antigen component of a widely registered oral cholera vaccine as well as a promising vector for either giving rise to mucosal anti-infective immunity or for inducing peripheral anti-inflammatory tolerance to chemically or genetically linked foreign antigens administered mucosally. CT and CTB have also recently been used as combined vectors and adjuvants for markedly promoting ex vivo dendritic cell (DC) vaccination with different antigens and also steering the immune response to the in vivo-reinfused DCs towards either broad Th1 + Th2 + CTL immunity (CT) or Th2 or tolerance (CTB). Another type of mucosal adjuvants is represented by bacterial DNA or synthetic oligodeoxynucleotides containing CpG-motifs, which especially when linked to CTB have been found to effectively stimulate both innate and adaptive mucosal immune responses. The properties and clinical potential of these different classes of adjuvants are being discussed. © 2004 Elsevier B.V. All rights reserved.
|
|
| 2. |
|
|
| 3. |
- Puerta, Rafael, et al.
(författare)
-
NR Conformance Testing of Analog Radio-over-LWIR FSO Fronthaul link for 6G Distributed MIMO Networks
- 2023
-
Ingår i: Opt. Fiber Commun. Conf. Exhib., OFC - Proc.. - : Institute of Electrical and Electronics Engineers Inc..
-
Konferensbidrag (refereegranskat)abstract
- We experimentally test the compliance with 5G/NR 3GPP technical specifications of an analog radio-over-FSO link at 9 μm. The ACLR and EVM transmitter requirements are fulfilled validating the suitability of LWIR FSO for 6G fronthaul. © 2023 The Author(s).
|
|
| 4. |
- Sun, J, et al.
(författare)
-
Comparative characterisation and phytotoxicity assessment of biochar and hydrochar derived from municipal wastewater microalgae biomass
- 2023
-
Ingår i: Bioresource Technology. - : Elsevier Ltd. - 0960-8524 .- 1873-2976. ; 386
-
Tidskriftsartikel (refereegranskat)abstract
- Microalgae, originating from a tertiary treatment of municipal wastewater, is considered a sustainable feedstock for producing biochar and hydrochar, offering great potential for agricultural use due to nutrient content and carbon storage ability. However, there are risks related to contamination and these need to be carefully assessed to ensure safe use of material from wastewater microalgae. Therefore, this study compared the properties and phototoxicity of biochar and hydrochar produced via pyrolysis and hydrothermal carbonisation (HTC) of microalgae under different temperatures and residence times. While biochar promoted germination and seedling growth by up to 11.0% and 70.0%, respectively, raw hydrochar showed strong phytotoxicity, due to the high content of volatile matter. Two post-treatments, dichloromethane (DCM) washing and further pyrolysis, proved to be effective methods for mitigating phytotoxicity of hydrochar. Additionally, biochar had 35.8–38.6% fixed carbon, resulting in higher carbon sequestration potential compared to hydrochar. © 2023 The Author(s)
|
|
| 5. |
- Sun, J, et al.
(författare)
-
Effect of magnesium ions on the adsorption of poly(acrylic acid) onto alumina
- 2001
-
Ingår i: Journal of The American Ceramic Society. - 0002-7820 .- 1551-2916. ; 84, s. 2710-2712
-
Tidskriftsartikel (refereegranskat)abstract
- The adsorption isotherms of poly(acrylic acid) (PAA) onto alumina powder have been determined as a function of pH, ionic strength, and magnesium-ion concentration. The adsorption of PAA is strongly enhanced by magnesium ions in alkaline media but less affected under acidic conditions. The adsorption isotherms display a maximum when PAA is fully complexed with magnesium ions in the solution, corresponding to a ratio of 0.25±0.05 [Mg2+]/[acrylic acid monomer]. The decrease in adsorbed amount with an increase in PAA concentration at constant magnesium-ion concentration is related to a decrease in the complexation ratio
|
|
| 6. |
- Sun, Vivian Z., et al.
(författare)
-
Overview and Results From the Mars 2020 Perseverance Rover's First Science Campaign on the Jezero Crater Floor
- 2023
-
Ingår i: Journal of Geophysical Research: Planets. - : John Wiley and Sons Inc. - 2169-9097 .- 2169-9100. ; 128:6
-
Tidskriftsartikel (refereegranskat)abstract
- The Mars 2020 Perseverance rover landed in Jezero crater on 18 February 2021. After a 100-sol period of commissioning and the Ingenuity Helicopter technology demonstration, Perseverance began its first science campaign to explore the enigmatic Jezero crater floor, whose igneous or sedimentary origins have been much debated in the scientific community. This paper describes the campaign plan developed to explore the crater floor's Máaz and Séítah formations and summarizes the results of the campaign between sols 100–379. By the end of the campaign, Perseverance had traversed more than 5 km, created seven abrasion patches, and sealed nine samples and a witness tube. Analysis of remote and proximity science observations show that the Máaz and Séítah formations are igneous in origin and composed of five and two geologic members, respectively. The Séítah formation represents the olivine-rich cumulate formed from differentiation of a slowly cooling melt or magma body, and the Máaz formation likely represents a separate series of lava flows emplaced after Séítah. The Máaz and Séítah rocks also preserve evidence of multiple episodes of aqueous alteration in secondary minerals like carbonate, Fe/Mg phyllosilicates, sulfates, and perchlorate, and surficial coatings. Post-emplacement processes tilted the rocks near the Máaz-Séítah contact and substantial erosion modified the crater floor rocks to their present-day expressions. Results from this crater floor campaign, including those obtained upon return of the collected samples, will help to build the geologic history of events that occurred in Jezero crater and provide time constraints on the formation of the Jezero delta.
|
|
