| 1. |
|
|
| 2. |
|
|
| 3. |
- Rando, Halie M, et al.
(författare)
-
Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through analysis of Viral Genomics and Structure
- 2021
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world infecting tens of millions of people with coronavirus disease 2019 (COVID-19). While this viral species was unknown prior to January 2020, its similarity to other coronaviruses that infect humans has allowed for rapid insight into the mechanisms that it uses to infect human hosts, as well as the ways in which the human immune system can respond. Here, we contextualize SARS-CoV-2 among other coronaviruses and identify what is known and what can be inferred about its behavior once inside a human host. Because the genomic content of coronaviruses, which specifies the virus's structure, is highly conserved, early genomic analysis provided a significant head start in predicting viral pathogenesis. The pathogenesis of the virus offers insights into symptomatology, transmission, and individual susceptibility. Additionally, prior research into interactions between the human immune system and coronaviruses has identified how these viruses can evade the immune system's protective mechanisms. We also explore systems-level research into the regulatory and proteomic effects of SARS-CoV-2 infection and the immune response. Understanding the structure and behavior of the virus serves to contextualize the many facets of the COVID-19 pandemic and can influence efforts to control the virus and treat the disease.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Lindberg, Stina, 1975-, et al.
(författare)
-
Detection of functional P fimbriae proteins in E. coli outer membrane vesicles
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Outer membrane vesicles (OMVs) are continuously released from the surface of Gram negative bacteria. The composition of the OMVs is similar to that of the outer membrane and may include periplasmic constituents. Studies have shown that OMVs also may have a role in the delivery of bacterial toxins to the extracellular space. Results: In this study we investigate the association of P fimbriae proteins to OMVs from both genetically manipulated E. coli laboratory strains and a uropathogenic isolate. We found that the OMVs could carry functionally active P fimbriae proteins on their surface and we observed specific attachment of OMVs to beads coated with the P fimbrial galabiose receptor. Conclusions: Our results suggest that OMVs can carry functionally active fimbrial proteins on their surface and that they may have a role in specific delivery of bacterial components to target cells.
|
|
| 10. |
- Mattsson, Tobias, 1990-, et al.
(författare)
-
Quantifying the crystal cargo of the Cerro Bayo cryptodome, Argentina; A window into pre-emplacement magma processes and storage conditions
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Shallow plumbing systems with intermediate to evolved volcanic systems can show complex magma recycling and recharge systematics. Such evidence is often stored in the information looked within the crystal cargo found in shallow systems. The Cerro Bayo cryptodome provides a classic example of such processes and was emplaced in the upper kilometre of the Miocene, back-arc Chachahuén volcano. Cerro Bayo formed during an extensive dome-building (and collapse) stage of the Chachahuén volcano, and is composed of a porphyritic trachyandesite which contains numerous mafic enclaves. This contribution investigates the deeper magma plumbing system and magmatic processes preceding the emplacement of Cerro Bayo with petrography, mineral chemistry, crystal size distributions and thermobarometry. The main crystals found in Cerro Bayo are plagioclase and amphiboles, found as mixed phenocryst/antecryst and glomerocryts, constituting about 30 vol. % of the rock. Minor mineral phases include pyroxene, apatite and magnetite. Several crystal populations are identified within the Cerro Bayo, which indicate differences within the growth histories of the populations. Some plagioclase crystal display resorbed textures and show zones with sharp increases in An mol% (up to 25 %), indicative of recharge events with hot (more mafic) magma. Whereas other crystals record only small temperature shifts, likely induced by latent heat of crystallisation. Amphibole and clinopyroxene barometers yield average crystallisation pressure estimates that range from 740 to 1036 MPa, however, they overlap within error of the barometers, revealing a storage region prior to shallow emplacement at about 30 to 40 km depth in the lower crust. The voluminous crystal cargo, diverse zoning patterns, sieve-textured plagioclase and the abundant enclaves in Cerro Bayo suggest that the magma was derived from a crystal mush storage region that was mobilised and partly mixed by the recharge of mafic melt.
|
|
