Sökning: WFRF:(Sund Malin 1972 )
> (2009)
> Bergh Anders >
Increased levels of...
Increased levels of macrophage-secreted Cathepsin S during Prostate Cancer progression in TRAMP mice and patients
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- Lindahl, Charlotta (författare)
- Umeå universitet,Patologi
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- Simonsson, Monika (författare)
- Umeå universitet,Patologi
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- Bergh, Anders (författare)
- Umeå universitet,Patologi
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- Thysell, Elin (författare)
- Umeå universitet,Kemiska institutionen
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- Antti, Henrik (författare)
- Umeå universitet,Kemiska institutionen
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- Sund, Malin, 1972- (författare)
- Umeå universitet,Kirurgi
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(creator_code:org_t)
- The International Institute of Anticancer Research, 2009
- 2009
- Engelska.
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Ingår i: Cancer Genomics and Proteomics. - : The International Institute of Anticancer Research. - 1109-6535 .- 1790-6245. ; 6:3, s. 149-159
- Relaterad länk:
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http://cgp.iiarjourn...
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https://urn.kb.se/re...
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Abstract
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- Background: Protein expression during prostate tumour progression in transgenic TRAMP mice was studied, with the aim of identifying proteins associated with tumour progression and castration resistant tumour growth. Materials and Methods: Protein expression was compared between normal mouse prostate, primary TRAMP tumours and peripheral metastases in long-term castrated TRAMP mice using 2-dimensional differential in-gel electrophoresis and MALDI TOF/TOF analysis. Results were verified with Western blot analysis and immunohisto-chemistry in the TRAMP model and samples from patients. Results: The active form of cathepsin S (Cat S) was identified as being significantly up-regulated in poorly differentiated TRAMP tumours and in castration-resistant metastases compared to normal mouse prostate and well-differentiated tumours. Increased Cat S levels were also found in high Gleason grade tumour areas in patients. Cat S was primarily expressed by tumour-infiltrating macrophages, as shown by double staining of Cat S and CD68 expressing cells. A significantly higher number of Cat S expressing macrophages was found in castration-resistant than in hormone naïve high grade tumours in patients. No relation was found between Cat S levels and suggested Cat S regulated, matrix-derived fragments of collagen IV or laminin 5 γ2. Conclusion: Macrophage-secreted Cat S levels increase during prostate cancer progression and could be an interesting target for therapy.
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