| 1. |
- Sundström, Johan, Professor, 1971-, et al.
(författare)
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Risk factors for subarachnoid haemorrhage : a nationwide cohort of 950 000 adults
- 2019
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Ingår i: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 48:6, s. 2018-2025
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Subarachnoid haemorrhage (SAH) is a devastating disease, with high mortality rate and substantial disability among survivors. Its causes are poorly understood. We aimed to investigate risk factors for SAH using a novel nationwide cohort consortium.METHODS: We obtained individual participant data of 949 683 persons (330 334 women) between 25 and 90 years old, with no history of SAH at baseline, from 21 population-based cohorts. Outcomes were obtained from the Swedish Patient and Causes of Death Registries.RESULTS: During 13 704 959 person-years of follow-up, 2659 cases of first-ever fatal or non-fatal SAH occurred, with an age-standardized incidence rate of 9.0 [95% confidence interval (CI) (7.4-10.6)/100 000 person-years] in men and 13.8 [(11.4-16.2)/100 000 person-years] in women. The incidence rate increased exponentially with higher age. In multivariable-adjusted Poisson models, marked sex interactions for current smoking and body mass index (BMI) were observed. Current smoking conferred a rate ratio (RR) of 2.24 (95% CI 1.95-2.57) in women and 1.62 (1.47-1.79) in men. One standard deviation higher BMI was associated with an RR of 0.86 (0.81-0.92) in women and 1.02 (0.96-1.08) in men. Higher blood pressure and lower education level were also associated with higher risk of SAH.CONCLUSIONS: The risk of SAH is 45% higher in women than in men, with substantial sex differences in risk factor strengths. In particular, a markedly stronger adverse effect of smoking in women may motivate targeted public health initiatives.
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| 2. |
- Jason, Johan, 1971-
(författare)
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Theory and Applications of Coupling Based Intensity Modulated Fibre-Optic Sensors
- 2008
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Optical fibre sensors can be used to measure a wide variety of properties. In some cases they have replaced conventional electronic sensors due to their possibility of performing measurements in environments suffering from electromagnetic disturbance, or in harsh environments where electronics cannot survive. In other cases they have had less success mainly due to the higher cost involved in fibre-optic sensor systems. Intensity modulated fibre-optic sensors normally require only low-cost monitoring systems principally based on light emitting diodes and photo diodes. The sensor principle itself is very simple when based on coupling between fibres, and coupling based intensity modulated sensors have found applications over a long time, mainly within position and vibration sensing. In this thesis new concepts and applications for intensity modulated fibre-optic sensors based on coupling between fibres are presented. From a low-cost and standard component perspective alternative designs are proposed and analyzed in order to find improved performance. The development of a sensor for an industrial temperature sensing application, involving aspects on multiplexing and fibre network installation, is presented. Optical time domain reflectometry (OTDR) is suggested as an efficient technique for multiplexing several coupling based sensors, and sensor network installation with blown fibre in micro ducts is proposed as a flexible and cost-efficient alternative to traditional cabling. A new sensor configuration using a fibre to a multicore fibre coupling and an image sensor readout system is proposed. With this system a high-performance sensor setup with a large measurement range can be realised without the need for precise fibre alignment often needed in coupling based sensors involving fibres with small cores. The system performance is analyzed theoretically with complete system simulations on different setups. An experimental setup is made based on standard fibre and image acquisition components, and differences from the theoretical performance are analyzed. It is shown that sub-µm accuracy should be possible to obtain, being the theoretical limit, and it is further suggested that the experimental performance is mainly related to two error sources: core position instability and differences between the real and the expected optical power distribution. Methods to minimize the experimental error are proposed and evaluated.
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| 3. |
- Persson, Gustav, et al.
(författare)
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Splenic contraction and cardiovascular responses are augmented during apnea compared to rebreathing in humans
- 2023
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Ingår i: Frontiers in Physiology. - : Frontiers Media SA. - 1664-042X. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- The spleen contracts during apnea, releasing stored erythrocytes, thereby increasing systemic hemoglobin concentration (Hb). We compared apnea and rebreathing periods, of equal sub-maximal duration (mean 137 s; SD 30), in eighteen subjects to evaluate whether respiratory arrest or hypoxic and hypercapnic chemoreceptor stimulation is the primary elicitor of splenic contraction and cardiovascular responses during apnea. Spleen volume, Hb, cardiovascular variables, arterial (SaO2), cerebral (ScO2), and deltoid muscle oxygen saturations (SmO2) were recorded during the trials and end-tidal partial pressure of oxygen (PETO2) and carbon dioxide (PETCO2) were measured before and after maneuvers. The spleen volume was smaller after apnea, 213 (89) mL, than after rebreathing, 239 (95) mL, corresponding to relative reductions from control by 20.8 (17.8) % and 11.6 (8.0) %, respectively. The Hb increased 2.4 (2.0) % during apnea, while there was no significant change with rebreathing. The cardiovascular responses, including bradycardia, decrease in cardiac output, and increase in total peripheral resistance, were augmented during apnea compared to during rebreathing. The PETO2 was higher, and the PETCO2 was lower, after apnea compared to after rebreathing. The ScO2 was maintained during maneuvers. The SaO2 decreased 3.8 (3.1) % during apnea, and even more, 5.4 (4.4) %, during rebreathing, while the SmO2 decreased less during rebreathing, 2.2 (2.8) %, than during apnea, 8.3 (6.2) %. We conclude that respiratory arrest per se is an important stimulus for splenic contraction and Hb increase during apnea, as well as an important initiating factor for the apnea-associated cardiovascular responses and their oxygen-conserving effects.
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