| 1. |
- Andersson, Mats, et al.
(författare)
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Laser spectroscopy of gas in scattering media at scales ranging from kilometers to millimeters
- 2007
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Ingår i: Laser Physics. - 1054-660X. ; 17:7, s. 893-902
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Tidskriftsartikel (refereegranskat)abstract
- Free gases are characterized by their narrow line width, and they can conveniently be studied by laser spectroscopy. The present paper discusses the monitoring of such ambient pressure gases, which are dispersed in scattering media such as aerosol-laden atmospheres, solids, or liquids. Atmospheric work basically constitutes the well-known field of differential absorption lidar (DIAL), while the study of free gas in solids and liquids was initiated more recently under the name of GASMAS (GAs in Scattering Media Absorption Spectroscopy). We discuss the connections between the two techniques, which are extensively used in our labortory. Thus, we span the field from trace-gas mapping of gases in the lower atmosphere to gas studies in construction materials, food products, and the human body. We show that the basic ideas are very similar, while the spatial and temporal scales vary greatly.
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| 2. |
- Johansson, Ann, et al.
(författare)
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Interstitial photodynamic therapy for primary prostate cancer incorporating realtime treatment dosimetry
- 2007
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Ingår i: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. - : SPIE. - 1042-4687 .- 1605-7422. ; 6427, s. 4270-4270
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Konferensbidrag (refereegranskat)abstract
- Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and shortterm response to the therapeutic irradiation. Within our group, an instrument for interstitial PDT on prostate tissue that incorporates realtime treatment feedback is being developed. The treatment protocol consists of two parts. The first part incorporates the pre-treatment plan with ultrasound investigations, providing the geometry for the prostate gland and surrounding risk organs, an iterative random-search algorithm to determine near-optimal fiber positions within the reconstructed geometry and a Block-Cimmino optimization algorithm for predicting individual fiber irradiation times. During the second part, the therapeutic light delivery is combined with measurements of the light transmission signals between the optical fibers, thus monitoring the tissue effective attenuation coefficient by means of spatially resolved spectroscopy. These data are then used as input for repeated runs of the Block-Cimmino optimization algorithm. Thus, the irradiation times for individual fibers are updated throughout the treatment in order to compensate for the influence of changes in tissue composition on the light distribution at the therapeutic wavelength.
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| 3. |
- Swartling, Johannes, et al.
(författare)
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System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer.
- 2010
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Ingår i: Journal of Biomedical Optics. - : SPIE-Intl Soc Optical Eng. - 1083-3668 .- 1560-2281. ; 15:5
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Tidskriftsartikel (refereegranskat)abstract
- The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment was to ablate the entire prostate while minimizing exposure to surrounding organs. The results indicate that online dosimetry based on real-time tissue optical property measurements enabled the light dose to be adapted and optimized. However, histopathological analysis of tissue biopsies taken six months post-PDT treatment showed there were still residual viable cancer cells present in the prostate tissue sections. The authors propose that the incomplete treatment of the prostate tissue could be due to a too low light threshold dose, which was set to 5 J∕cm2.
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| 4. |
- Alnis, Janis, et al.
(författare)
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Laser spectroscopy of free molecular oxygen dispersed in wood materials
- 2003
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Ingår i: Applied Physics B. - : Springer Science and Business Media LLC. - 0946-2171 .- 1432-0649. ; 77:6-7, s. 691-695
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Tidskriftsartikel (refereegranskat)abstract
- The recently introduced Gas in Scattering Media Absorption Spectroscopy (GASMAS) technique is applied to the study of various wood samples. Molecular oxygen in the pores of the strongly scattering material is detected using diode laser spectroscopy around 760 nm. Diffuse light propagation in these media is studied by time-dispersion measurements. Furthermore, anisotropy related to the fibre structure of wood and gas diffusion properties are studied. Promising extensions of the experiments are discussed.
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| 5. |
- Andersson, Mats, et al.
(författare)
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Spectroscopic studies of wood-drying processes
- 2006
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Ingår i: Optics Express. - 1094-4087. ; 14:8, s. 3641-3653
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Tidskriftsartikel (refereegranskat)abstract
- By the use of wavelength-modulation diode laser spectroscopy, water vapor and oxygen are detected in scattering media nonintrusively, at 980 nm and 760 nm, respectively. The technique demonstrated is based on the fact that free gases have extremely sharp absorption structures in comparison with the broad features of bulk material. Water vapor and oxygen measurements have been performed during the drying process of wood. The results suggest that the demonstrated technique can give information about the drying process of wood to complement that of commercially available moisture meters. In particular, the time when all the free water has evaporated from the wood can be readily identified by a strong falloff in the water vapor signal accompanied by the reaching of a high-level plateau in the molecular oxygen signal. Furthermore, the same point is identified in the differential optical absorption signal for liquid water, with a sharp increase by an order of magnitude in the ratio of the signal intensities at 980 nm and 760 nm.
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| 6. |
- Anund, Anna, 1964-, et al.
(författare)
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Night-time scenarios in simulators : a prestudy of needs, knowledge and possible solutions
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The study in this publication investigates the need and potential for night-time scenarios in driving simulators, determines how such night-time scenarios could be reproduced and identifies the objects most important to reproduce. Although on average 12 out of every 24 hours are dark and considering that most situations are more demanding for drivers in dark conditions, simulations of driving scenarios with different degrees of darkness are not common. The project work comprised a pre-study that involved an investigation of the need and potential of night-time scenarios with the help of input from different stakeholders, consolidation of what is known up to now through benchmarking and state of the art, and a review of available technical solutions. The objective was to identify pros and cons with existing solutions and aspects that are important to consider in order to reproduce the most important components in realistic night-time scenarios. Based on the results, six important use cases were identified and two of these (‘Driver fatigue’ and ‘Objects without light sources’) were studied in more detail. It was concluded that for night-time scenarios there is enough darkness in general in the simulator environment. The question is whether it is possible to create sufficient contrast for objects that are meant to be observable. For daytime scenarios, the light levels in the simulator are clearly unrealistically low and this limitation might even trigger unwanted sleepiness.
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| 7. |
- Bagni, Tommaso, et al.
(författare)
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Modeling Results of the Quench Behavior of a Nb-Ti Canted-Cosine-Theta Corrector Magnet for LHC
- 2024
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Ingår i: IEEE transactions on applied superconductivity (Print). - : Institute of Electrical and Electronics Engineers (IEEE). - 1051-8223 .- 1558-2515. ; 34:5, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- A newly designed superconducting magnet of the Canted-Cosine-Theta (CCT) type was developed as a result of a collaboration between Swedish universities (Uppsala and Linneaus) and Swedish industries. This magnet was designed to function as a replacement of the present LHC orbit corrector magnets, which are approaching their end of life due to the radiation load. As a result, the new CCT magnet was developed to be more radiation tolerant and to constitute a one-to-one replacement to the currently installed version, which is a 1 m long 70 mm double aperture dipole magnet. The final magnet, which is currently under construction, will be tested at FREIA laboratory at Uppsala University and generate a magnetic field of 3.3 T and an integrated field of 2.8 Tm at about 85 A. To examine the magnet quench behavior and to identify a suitable quench protection system, the 3D electro-magnetic and thermal behavior of the coil was modeled using the RAT-Raccoon software. Based on the simulation results, a Metrosil varistor was selected to protect the magnet during the test. In this article, we report the results of the numerical analysis. The magnet model is equipped with a spot heater to initialize the quench and the temperature and voltages are monitored during the avalanche effect. The simulated current decay and the hot-spot temperature are analyzed with a focus on the impact of quench-back on the magnet protection.
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| 8. |
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| 9. |
- Bengtsson, Magnus, et al.
(författare)
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Fluorescence lidar imaging of fungal growth on high-voltage outdoor composite insulators
- 2005
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Ingår i: Optics and Lasers in Engineering. - : Elsevier BV. - 0143-8166 .- 1873-0302. ; 43:6, s. 624-632
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Tidskriftsartikel (refereegranskat)abstract
- Remote fluorescence imaging of fungal growth on polymeric high-voltage insulators was performed using a mobile lidar system with a laser wavelength of 355 nm. Insulator areas contaminated by fungal growth could be distinguished from clean surfaces and readily be imaged. The experiments were supported by detailed spectral studies performed in laboratory using a fibre-optic fluorosensor incorporating an optical multi-channel analyser system (OMA) and a nitrogen laser emitting radiation at 33 7 nm.
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| 10. |
- Bengtsson, Magnus, et al.
(författare)
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Fungus covered insulator materials studied with laser-induced fluorescence and principal component analysis
- 2005
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Ingår i: Applied Spectroscopy. - : SAGE Publications. - 0003-7028 .- 1943-3530. ; 59:8, s. 1037-1041
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Tidskriftsartikel (refereegranskat)abstract
- A method combining laser-induced fluorescence and principal component analysis to detect and discriminate between algal and fungal growth on insulator materials has been studied. Eight fungal cultures and four insulator materials have been analyzed. Multivariate classifications were utilized to characterize the insulator material, and fungal growth could readily be distinguished from a clean surface. The results of the principal component analyses make it possible to distinguish between algae infected, fungi infected, and clean silicone rubber materials. The experiments were performed in the laboratory using a fiber-optic fluorosensor that consisted of a nitrogen laser and an optical multi-channel analyzer system.
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