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  • Wuttke, Matthias, et al. (författare)
  • A catalog of genetic loci associated with kidney function from analyses of a million individuals
  • 2019
  • Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
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  • Backman, Erik, 1972-, et al. (författare)
  • Where does environmental sustainability fit in the changing landscapes of outdoor sports? : An analysis of logics of practice in artificial sport landscapes
  • 2023
  • Ingår i: Sport, Education and Society. - : Taylor & Francis Group. - 1357-3322 .- 1470-1243. ; 28:6, s. 727-740
  • Tidskriftsartikel (refereegranskat)abstract
    • Environmental sustainability in sport is an increasingly important issue. In this paper, we want to highlight a specific phenomenon, namely artificially constructed landscapes and the outdoor sport activities that take place therein. More specifically, we are interested in the logics that govern peoples’ practice of sport in such artificial landscapes and what challenges with regards to environmental sustainability that follow from these logics. The purpose of this paper is to identify what individual athletes perceive as meaningful logics when practicing sport in artificial landscapes and to analyse and discuss potential environmental consequences of these logics. The sports we focus on are cross-country skiing and canoe slalom, two sports that historically have been dependent on specific geographies and contexts. We build on two research questions: What logics of practice govern individual athletes’ practice of sport in artificial landscapes? And what environmental challenges are potential consequences of the logics that are expressed by the athletes? Our findings indicate that the logic of performance is dominant for the sport practitioners who train in artificial landscapes, at the expense of perspectives such as nature experience and environmental sustainability. If performance is key, then the role of the training landscape is also first and foremost to present the best possible conditions for performance. But if the athlete/exerciser see their training as a means of experiencing nature, then other values than performance and comparability can become more important. When the environmental impact of individual athletes and of the artificial landscapes in which they do their training come under increased scrutiny, the role of logics of practice in the sport and movement culture needs further attention. Being aware of nature and the environment is also a logic that could be found meaningful in the process of making sports more sustainable.
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