| 1. |
- Cherian, Dennis, 1989-, et al.
(författare)
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Flexible Organic Electronic Ion Pump Fabricated Using Inkjet Printing and Microfabrication for Precision In Vitro Delivery of Bupivacaine
- 2023
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Ingår i: Advanced Healthcare Materials. - : John Wiley and Sons Inc. - 2192-2640 .- 2192-2659. ; 12:24, s. 2300550-
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Tidskriftsartikel (refereegranskat)abstract
- The organic electronic ion pump (OEIP) is an on-demand electrophoretic drug delivery device, that via electronic to ionic signal conversion enables drug delivery without additional pressure or volume changes. The fundamental component of OEIPs is their polyelectrolyte membranes which are shaped into ionic channels that conduct and deliver ionic drugs, with high spatiotemporal resolution. The patterning of these membranes is essential in OEIP devices and is typically achieved using laborious microprocessing techniques. Here, the development of an inkjet printable formulation of polyelectrolyte is reported, based on a custom anionically functionalized hyperbranched polyglycerol (i-AHPG). This polyelectrolyte ink greatly simplifies the fabrication process and is used in the production of free-standing OEIPs on flexible polyimide (PI) substrates. Both i-AHPG and the OEIP devices are characterized, exhibiting favorable iontronic characteristics of charge selectivity and the ability to transport aromatic compounds. Further, the applicability of these technologies is demonstrated by the transport and delivery of the pharmaceutical compound bupivacaine to dorsal root ganglion cells with high spatial precision and effective nerve blocking, highlighting the applicability of these technologies for biomedical scenarios. © 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
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| 2. |
- Cong, Jiayan, et al.
(författare)
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Bis(1,1-bis(2-pyridyl)ethane)copper(I/II) as an efficient redox couple for liquid dye-sensitized solar cells
- 2016
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Ingår i: Journal of Materials Chemistry. - 0959-9428 .- 1364-5501. ; 4:38, s. 14550-14554
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Tidskriftsartikel (refereegranskat)abstract
- A new redox couple, [Cu(bpye)2]+/2+, has been synthesized, and applied in dye-sensitized solar cells (DSSCs). Overall efficiencies of 9.0% at 1 sun and 9.9% at 0.5 sun were obtained, which are considerably higher than those obtained for cells containing the reference redox couple, [Co(bpy)3]2+/3+. These results represent a record for copper-based complex redox systems in liquid DSSCs. Fast dye regeneration, sluggish recombination loss processes, faster electron self-exchange reactions and suitable redox potentials are the main reasons for the observed increase in efficiency. In particular, the main disadvantage of cobalt complex-based redox couples, charge-transport problems, appears to be resolved by a change to copper complex redox couples. The results make copper complex-based redox couples very promising for further development of highly efficient DSSCs.
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| 3. |
- Eriksson, Henrik, et al.
(författare)
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Smartphones as Wireless Reflector Tags?
- 2014
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Rapport (refereegranskat)abstract
- This report investigates the feasibility of using smartphones as wireless reflector tags. A smartphone communicates its GNSS positioning data via peer-to-peer connections to nearby road users to notify its presence. Appropriate use cases are studied based on accident data. Different communication protocols and a pseudo differencing positioning technique are evaluated. Possibilities and obstacles are presented.
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| 4. |
- Koch, Daniel, et al.
(författare)
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2,2 '-Biindolyl Reactions with Aldehydes
- 2016
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Ingår i: European Journal of Organic Chemistry. - : Wiley-VCH Verlag. - 1434-193X .- 1099-0690. ; :7, s. 1389-1396
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Tidskriftsartikel (refereegranskat)abstract
- 2,2'-Biindolyl has been condensed with aromatic and aliphatic aldehydes and products featuring 10-membered rings have been obtained. Thus, benzaldehyde gave compound 24a as the primary product, which readily underwent transannular oxidative coupling to 25a. The structures of both compounds were confirmed by X-ray crystallography. The product from 2,2'-biindolyl and formaldehyde under strongly acidic conditions was slightly different leading to compound 11, whose structure also was confirmed by X-ray crystallography. In this case, two molecules of 2,2'-biindolyl reacted with six molecules of formaldehyde.
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| 5. |
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| 6. |
- Lindahl, Niklas, 1981, et al.
(författare)
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Determination of the Bending Rigidity of Graphene via Electrostatic Actuation of Buckled Membranes
- 2012
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Ingår i: Nano Letters. - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 12:7, s. 3526-3531
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Tidskriftsartikel (refereegranskat)abstract
- Classical continuum mechanics is used extensively to predict the properties of nanoscale materials such as graphene. The bending rigidity, kappa, is an important parameter that is used, for example, to predict the performance of graphene nanoelectromechanical devices and also ripple formation. Despite its importance, there is a large spread in the theoretical predictions of kappa for few-layer graphene. We have used the snap-through behavior of convex buckled graphene membranes under the application of electrostatic pressure to determine experimentally values of kappa for double-layer graphene membranes. We demonstrate how to prepare convex-buckled suspended graphene ribbons and fully clamped suspended membranes and show how the determination of the curvature of the membranes and the critical snap-through voltage, using AFM, allows us to extract kappa. The bending rigidity of bilayer graphene membranes under ambient conditions was determined to be 35.5(-15.0)(+20.0) eV. Monolayers are shown to have significantly lower kappa than bilayers.
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| 7. |
- Olsson, Tomas, et al.
(författare)
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Fault Diagnosis of Heavy Duty Machines : Automatic Transmission Clutches
- 2014
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Ingår i: Proceedings of the ICCBR 2014 Workshops.
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Konferensbidrag (refereegranskat)abstract
- This paper presents a generic approach to fault diagnosis of heavy duty machines that combines signal processing, statistics, machine learning, and case-based reasoning for on-board and off-board analysis. The used methods complement each other in that the on-board methods are fast and light-weight, while case-based reasoning is used off-board for fault diagnosis and for retrieving cases as support in manual decision mak- ing. Three major contributions are novel approaches to detecting clutch slippage, anomaly detection, and case-based diagnosis that is closely in- tegrated with the anomaly detection model. As example application, the proposed approach has been applied to diagnosing the root cause of clutch slippage in automatic transmissions.
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| 8. |
- Roy, Arghyamalya, 1992-, et al.
(författare)
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Electrophoretic Delivery of Clinically Approved Anesthetic Drug for Chronic Pain Therapy
- 2023
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Ingår i: Advanced Therapeutics. - : John Wiley and Sons Inc. - 2366-3987. ; 6:7
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Tidskriftsartikel (refereegranskat)abstract
- Despite a range of available pain therapies, most patients report so-called “breakthrough pain.” Coupled with global issues like opioid abuse, there is a clear need for advanced therapies and technologies for safe and effective pain management. Here the authors demonstrate a candidate for such an advanced therapy: precise and fluid-flow-free electrophoretic delivery via organic electronic ion pumps (OEIPs) of the commonly used anesthetic drug bupivacaine. Bupivacaine is delivered to dorsal root ganglion (DRG) neurons in vitro. DRG neurons are a good proxy for pain studies as they are responsible for relaying ascending sensory signals from nociceptors (pain receptors) in the peripheral nervous system to the central nervous system. Capillary based OEIPs are used due to their probe-like and free-standing form factor, ideal for interfacing with cells. By delivering bupivacaine with the OEIP and recording dose versus response (Ca2+ imaging), it is observed that only cells close to the OEIP outlet (≤75 µm) are affected (“anaesthetized”) and at concentrations up to 10s of thousands of times lower than with bulk/bolus delivery. These results demonstrate the first effective OEIP deliveryof a clinically approved and widely used analgesic pharmaceutical, and thus are a major translational milestone for this technology. © 2023 The Authors.
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| 9. |
- Svensson, Johannes, et al.
(författare)
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Carbon Nanotube Field Effect Transistors with Suspended Graphene Gates
- 2011
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Ingår i: Nano Letters. - : American Chemical Society (ACS). - 1530-6992 .- 1530-6984. ; 11:9, s. 3569-3575
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Tidskriftsartikel (refereegranskat)abstract
- Novel field effect transistors with suspended graphene gates are demonstrated. By incorporating mechanical motion of the gate electrode, it is possible to improve the switching characteristics compared to a static gate, as shown by a combination of experimental measurements and numerical simulations. The mechanical motion of the graphene gate is confirmed by using atomic force microscopy to directly measure the electrostatic deflection. The device geometry investigated here can also provide a sensitive measurement technique for detecting high-frequency motion of suspended membranes as required, e.g., for mass sensing.
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