| 1. |
- Rosengren, Annika, 1951, et al.
(författare)
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Long-term excess risk of heart failure in people with type 1 diabetes: a prospective case-control study.
- 2015
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Ingår i: The lancet. Diabetes & endocrinology. - 2213-8595. ; 3:11, s. 876-85
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Tidskriftsartikel (refereegranskat)abstract
- Diabetes is an established risk factor for heart failure, but because nearly all heart failure occurs in older individuals, the excess risk and risk factors for heart failure in individuals with type 1 diabetes are not known. We aimed to determine the excess risk of heart failure in individuals with type 1 diabetes overall and by different levels of glycaemic control and albuminuria.
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| 2. |
- Vestberg, Daniel, et al.
(författare)
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Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
- 2018
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Ingår i: Open Heart. - : BMJ. - 2053-3624. ; 5:1, s. 1-7
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Tidskriftsartikel (refereegranskat)abstract
- Objective To investigate the potential relationship between body mass index (BMI) and the risk for myocardial infarction and coronary death in patients with type 1 diabetes. Methods We studied patients with type 1 diabetes included in the Swedish National Diabetes Registry during 2002-2004 and followed them until a discharge diagnosis for myocardial infarction, acute coronary event, death or until 31 December 2011. Cox regression was used to estimate relative risks. Results In 17 499 patients with type 1 diabetes (mean age 39.4 years; mean BMI 25.2 kg/m(2)), 819 were diagnosed with myocardial infarction as a primary or secondary diagnosis during a mean follow-up of 8.5 years (maximum 9.9 years). Estimated with Cox regression, there was no significant effect of increased BMI on the risk of myocardial infarction (HR 1.4 (95% CI 0.7 to 2.5) in the group with BMI >35 kg/m(2) compared with BMI 18.5-25 kg/m(2). There was no association between BMI and coronary mortality, acute coronary events or all-cause mortality after adjusting for other known risk factors. Underweight patients (BMI <18.5 kg/m(2)) had increased hazard for coronary (HR 5.0 (95% CI 1.5 to 16.9)) and all-cause mortality (HR 5.4 (95% CI 3.1 to 9.6)) compared with BMI 18.5-25 kg/m(2). Conclusions Among patients with type 1 diabetes, increased BMI is not a significant independent risk factor for myocardial infarction or coronary death after adjustment for other risk factors. Low BMI (less than 18.5 kg/m(2)) is associated with mortality from coronary or any cause.
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| 3. |
- Vestberg, Daniel, et al.
(författare)
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Decreased eGFR as a Risk Factor for Heart Failure in 13 781 Individuals With Type 1 Diabetes.
- 2016
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Ingår i: Journal of diabetes science and technology. - : SAGE Publications. - 1932-2968. ; 10:1, s. 131-136
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Tidskriftsartikel (refereegranskat)abstract
- Impaired renal function is a well-known risk factor of cardiovascular disease, but its relation to heart failure in individuals with type 1 diabetes has been sparsely studied. The aim of our study was to quantify the risk increase for development of heart failure with decreasing kidney function in individuals with type 1 diabetes.
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| 4. |
- Vestberg, Daniel, et al.
(författare)
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Decreased eGFR as a risk factor for heart failure in 13,781 patients with type 1 diabetes
- 2015
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Ingår i: Diabetologia. 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Stockholm, Sverige, 14-18 september 2015.. - 0012-186X .- 1432-0428. ; 58
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- http://www.easdvirtualmeeting.org/resources/decreased-egfr-as-a-risk-factor-for-heart-failure-in-13-781-patients-with-type-1-diabetes--3
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| 5. |
- Vestberg, Daniel, et al.
(författare)
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Relationship Between Overweight and Obesity With Hospitalization for Heart Failure in 20,985 Patients With Type 1 Diabetes: A population-based study from the Swedish National Diabetes Registry
- 2013
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 36:9, s. 2857-2861
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVETo investigate the potential relationship between overweight, obesity, and severe obesity and the risk of hospitalization for heart failure (HF) in patients with type 1 diabetes.RESEARCH DESIGN AND METHODSWe studied patients with type 1 diabetes included in the Swedish National Diabetes Register during 1998-2003, and they were followed-up until hospitalization for HF, death, or 31 December 2009. Cox regression was used to estimate relative risks.RESULTSIn a sample of 20,985 type 1 diabetic patients (mean age, 38.6 years; mean BMI, 25.0 kg/m2), 635 patients were hospitalized with HF as a primary or secondary diagnosis during a median follow-up of 9.1 years. Cox regression adjusting for age, sex, diabetes duration, smoking, HbA1c, systolic and diastolic blood pressures, and baseline and intercurrent comorbidities (including myocardial infarction) showed a significant relationship between BMI and hospitalization for HF (P < 0.0001). In reference to patients in the BMI 20-25 kg/m2 category, hazard ratios (HRs) were as follows: HR 1.22 (95% CI, 0.83-1.78) for BMI <20 kg/m2; HR 0.94 (95% CI 0.78-1.12) for BMI 25-30 kg/m2; HR 1.55 (95% CI, 1.20-1.99) for BMI 30-35 kg/m2; and HR 2.90 (95% CI, 1.92-4.37) for BMI >/=35 kg/m2.CONCLUSIONSObesity, particularly severe obesity, is strongly associated with hospitalization for HF in patients with type 1 diabetes, whereas no similar relation was present in overweight and low body weight.
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