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1.
  • Nielsen, Niklas, et al. (författare)
  • Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design
  • 2012
  • Ingår i: American Heart Journal. - Mosby. - 1097-6744. ; 163:4, s. 541-548
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32 degrees C to 34 degrees C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known. Methods The TTM trial is an investigator-initiated, international, randomized, parallel-group, and assessor-blinded clinical trial designed to enroll at least 850 adult, unconscious patients resuscitated after out-of-hospital cardiac arrest of a presumed cardiac cause. The patients will be randomized to a target temperature management of either 33 degrees C or 36 degrees C after return of spontaneous circulation. In both groups, the intervention will last 36 hours. The primary outcome is all-cause mortality at maximal follow-up. The main secondary outcomes are the composite outcome of all-cause mortality and poor neurologic function (cerebral performance categories 3 and 4) at hospital discharge and at 180 days, cognitive status and quality of life at 180 days, assessment of safety and harm. Discussion The TTM trial will investigate potential benefit and harm of 2 target temperature strategies, both avoiding hyperthermia in a large proportion of the out-of-hospital cardiac arrest population. (Am Heart J 2012; 163:541-8.)
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2.
  • Nielsen, Niklas, et al. (författare)
  • Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design
  • 2012
  • Ingår i: American Heart Journal. - Elsevier. - 0002-8703 .- 1097-6744. ; 163:4, s. 541-548
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32 degrees C to 34 degrees C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known. less thanbrgreater than less thanbrgreater thanMethods The TTM trial is an investigator-initiated, international, randomized, parallel-group, and assessor-blinded clinical trial designed to enroll at least 850 adult, unconscious patients resuscitated after out-of-hospital cardiac arrest of a presumed cardiac cause. The patients will be randomized to a target temperature management of either 33 degrees C or 36 degrees C after return of spontaneous circulation. In both groups, the intervention will last 36 hours. The primary outcome is all-cause mortality at maximal follow-up. The main secondary outcomes are the composite outcome of all-cause mortality and poor neurologic function (cerebral performance categories 3 and 4) at hospital discharge and at 180 days, cognitive status and quality of life at 180 days, assessment of safety and harm. less thanbrgreater than less thanbrgreater thanDiscussion The TTM trial will investigate potential benefit and harm of 2 target temperature strategies, both avoiding hyperthermia in a large proportion of the out-of-hospital cardiac arrest population.</p>
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3.
  • Platonov, Pyotr G., et al. (författare)
  • Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillator Therapy in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
  • 2019
  • Ingår i: American Journal of Cardiology. - Excerpta Medica. - 0002-9149. ; 123:7, s. 1156-1162
  • Tidskriftsartikel (refereegranskat)abstract
    • Implantable cardioverter-defibrillator (ICD) therapy remains a corner stone of sudden cardiac death (SCD) prevention in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to assess predictors of appropriate ICD therapies in the Scandinavian cohort of ARVC patients who received ICD for primary prevention of SCD. Study group comprised of 79 definite ARVC patients by 2010 Task Force criteria (60% male, age at ICD implant 39 ± 14 years) who were enrolled in the Nordic ARVC Registry and received an ICD for primary SCD prevention. The primary end point of appropriate ICD shock or death from any cause was assessed and compared with 137 definite ARVC patients who received ICD for secondary SCD prevention (74% male, age at ICD implant 42 ± 15 years). In the study group, 38% were ≤35 years of age at baseline, 25% had nonsustained ventricular tachycardia, and 29% had syncope at baseline. Major repolarization abnormality (hazard ratio = 4.00, 95% confidence interval 1.30 to 12.30, p = 0.015) and age ≤35 years (hazard ratio = 4.21, 95% confidence interval 1.49 to 11.85, p = 0.001) independently predicted the primary end point. The outcome did not differ between the primary prevention patients with either of these risk factors and the secondary prevention cohort (2% to 4% annual event rate) whereas patients without risk factors did not have any appropriate ICD shocks during follow-up. In conclusion, young age at ARVC diagnosis and major repolarization abnormality independently predict ICD shocks or death in the primary prevention ICD recipients and associated with the event rate similar to the one observed in the secondary prevention cohort. Our data indicate the benefit of ICD for primary prevention in patients with any of these risk factors.
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4.
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5.
  • Svensson, Jesper, et al. (författare)
  • Design of navigational support for task oriented reading in e-newspapers
  • 2006
  • Ingår i: Proceedings of the 29th IRIS. ; s. 21
  • Konferensbidrag (refereegranskat)abstract
    • <p>This paper aims to explore how the navigational support in an e-newspaper should be  designed to support the users task oriented reading behavior. An e-newspaper is a newspaper produced on e-paper, which combines the readability of paper, with the possibilities of digital media such as streaming updates, interactivity and multimedia. One advantage with the e-paper technology is its high contrast and readability; it uses no backlight and only consumes power when the pages are updated. This study is part of the European DigiNews project where three high fidelity e-newspaper prototypes has been produced in cooperation with readers and newspaper designers. These prototypes have been tested on 36 readers to examine how to design navigational support to aid task oriented reading. Six guidelines for have been generated from the results of the study which covers information structure, hyperlinks, feedback and visual cues.</p>
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6.
  • Adolfson, Malin, et al. (författare)
  • Monetary policy trade-offs in an estimated open-economy DSGE model
  • 2014
  • Ingår i: Journal of Economic Dynamics and Control. - 0165-1889 .- 1879-1743. ; 42, s. 33-49
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>This paper studies the trade-offs between stabilizing CPI inflation and alternative measures of the output gap in Ramses, the Riksbank's estimated dynamic stochastic general equilibrium (DSGE) model of a small open economy. Our main finding is that the trade-off between stabilizing CPI inflation and the output gap strongly depends on which concept of potential output in the output gap between output and potential output is used in the loss function. If potential output is defined as a smooth trend this trade-off is much more pronounced compared to the case when potential output is defined as the output level that would prevail if prices and wages were flexible.</p>
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7.
  • Adolfson, Malin, et al. (författare)
  • Optimal Money Policy in an Operational Medium-Sized DSGE Model
  • 2011
  • Ingår i: Journal of Money, Credit and Banking. - 0022-2879 .- 1538-4616. ; 43, s. 1287-1331
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We show how to construct optimal policy projections in Ramses, the Riksbank's open-economy medium-sized dynamic stochastic general equilibrium model for forecasting and policy analysis. Bayesian estimation of the parameters of the model indicates that they are relatively invariant to alternative policy assumptions and supports our view that the model parameters may be regarded as unaffected by the monetary policy specification. We discuss how monetary policy, and in particular the choice of output gap measure, affects the transmission of shocks. Finally, we use the model to assess the recent Great Recession in the world economy and how its impact on the economic development in Sweden depends on the conduct of monetary policy. This provides an illustration on how Rames incoporates large international spillover effects.</p>
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8.
  • Adolphi, Florian, et al. (författare)
  • Persistent link between solar activity and Greenland climate during the Last Glacial Maximum
  • 2014
  • Ingår i: Nature Geoscience. - Nature Publishing Group. - 1752-0908. ; 7:9, s. 662-666
  • Tidskriftsartikel (refereegranskat)abstract
    • Changes in solar activity have previously been proposed to cause decadal- to millennial-scale fluctuations in both the modern and Holocene climates(1). Direct observational records of solar activity, such as sunspot numbers, exist for only the past few hundred years, so solar variability for earlier periods is typically reconstructed from measurements of cosmogenic radionuclides such as Be-10 and C-14 from ice cores and tree rings(2,3). Here we present a high-resolution Be-10 record from the ice core collected from central Greenland by the Greenland Ice Core Project (GRIP). The record spans from 22,500 to 10,000 years ago, and is based on new and compiled data(4-6). Using C-14 records(7,8) to control for climate-related influences on Be-10 deposition, we reconstruct centennial changes in solar activity. We find that during the Last Glacial Maximum, solar minima correlate with more negative delta O-18 values of ice and are accompanied by increased snow accumulation and sea-salt input over central Greenland. We suggest that solar minima could have induced changes in the stratosphere that favour the development of high-pressure blocking systems located to the south of Greenland, as has been found in observations and model simulations for recent climate(9,10). We conclude that the mechanism behind solar forcing of regional climate change may have been similar under both modern and Last Glacial Maximum climate conditions.
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9.
  • Backlund, Per, et al. (författare)
  • Evaluation of usefulness of the Elinor console for home-based stroke rehabilitation
  • 2011
  • Ingår i: Proceedings of the 3rd International Conference in Games and Virtual Worlds for Serious Applications (VS-Games 2011). - IEEE Computer Society. - 978-0-7695-4419-9 - 978-1-4577-0316-4 ; s. 98-103
  • Konferensbidrag (refereegranskat)abstract
    • <p>Virtual rehabilitation has emerged as a promising tool over the last decade. However the field is diverse and there is no unified understanding of the concept and in which situations it should be used. The most common usage context is a rehabilitation clinic but there is an urge to offer motivating virtual rehabilitation to be used in the homes of patients. The main drive for using such systems is to enhance motivation by introducing an interesting challenge and an element of fun. This paper describes and evaluates the feasibility of Elinor, a gamebased system for stroke rehabilitation in the home.</p><p>The Elinor prototype has been positively evaluated with respect to its usability, user acceptance and motivational factors. This paper reports on the initial findings concerning the rehabilitation effect of Elinor. No persons suffered any serious adverse effects from training. We had positive results with respect to the assessment of motor and process skills (AMPS). Even though these improvements were not significant they are still positive enough to motivate future work. The self-reported improvements in the motor activity logs (MAL) also motivate future work.</p>
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10.
  • Backlund, Per, et al. (författare)
  • Games on prescription! : Evaluation of the Elinor console for home-based stroke rehabilitation
  • 2013
  • Ingår i: Transactions on Edutainment IX. - Springer Berlin/Heidelberg. - 978-3-642-37041-0 - 978-3-642-37042-7 ; s. 49-64
  • Bokkapitel (refereegranskat)abstract
    • <p>This paper reports the feasibility of Elinor, a game-based system for stroke rehabilitation in the home. The Elinor prototype has been positively evaluated with respect to its usability, user acceptance and motivational factors as well as its rehabilitation effect. This paper reports the findings from the whole project. To summarize the results, we find that game factors can be used to enhance motivation for rehabilitation. We had positive results with respect to many of the rehabilitation measurements employed. For example, the assessment of motor and process skills was positive as were also the self-reported improvements in daily activities. Furthermore, it seems that an increased self-efficacy with respect to the belief that the treatment can have an effect is positive and expected to increase motivation to undergo necessary rehabilitation. The usability and perceived usefulness of the system were also positively evaluated and the subjects expressed a positive attitude towards the system as well as a belief in its usefulness. © 2013 Springer-Verlag Berlin Heidelberg.</p>
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