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Budd-Chiari syndrom...
Budd-Chiari syndrome in Sweden : epidemiology, clinical characteristics and survival - an 18-year experience
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- Rajani, Rupesh (författare)
- Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet
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- Melin, Tor (författare)
- University Hospital, Lund
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- Björnsson, Einar (författare)
- Sahlgrenska University Hospital, Göteborg
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- Broomé, Ulrika (författare)
- Karolinska University Hospital, Stockholm
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- Sangfelt, Per (författare)
- University Uppsala Hospital, Uppsala
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- Danielsson, Åke (författare)
- Umea University Hospital, Umeå
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- Gustavsson, Anders (författare)
- Örebro universitet,Hälsoakademin,University Hospital, Örebro
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- Grip, Olof (författare)
- Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Malmö University Hospital, Malmö
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- Svensson, Hans (författare)
- Vrinnevi Hospital, Norrköping
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- Lööf, Lars (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Västerås City Hospital, Västerås
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- Wallerstedt, Sven (författare)
- Östra Hospital, Gothenberg
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- Almer, Sven (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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(creator_code:org_t)
- Oxford : Blackwell Munksgaard, 2009
- 2009
- Engelska.
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Ingår i: Liver international (Print). - Oxford : Blackwell Munksgaard. - 1478-3223 .- 1478-3231. ; 29:2, s. 253-259
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The exact incidence and prevalence of Budd-Chiari syndrome (BCS) is unknown in the general population. Published reports differ in terms of the clinical characteristics, effects of therapy and survival. AIMS: To investigate the epidemiology, clinical presentation and survival in patients with BCS. METHODS: Retrospective multicentre study in Sweden reviewing the medical records of all patients with BCS 1986-2003, identified from the computerised diagnosis database of 11 hospitals, including all university hospitals and liver transplantation centres. RESULTS: Forty-three patients with BCS were identified, of whom nine (21%) had concomitant portal vein thrombosis. The mean age-standardised incidence and prevalence rates in 1990-2001 were calculated to be 0.8 per million per year and 1.4 per million inhabitants respectively. Myeloproliferative disorders (38%), thrombophilic factors (31%) and oral contraceptives (30%) were common aetiological factors. Two or more risk factors were present in 44%. In 23%, no risk factor was evident. The median follow-up time was 2.7 years. Seventy-two percent were on anticoagulant therapy during follow-up. Transjugular intrahepatic portosystemic shunting, surgical shunting procedures and liver transplantation were performed in 4, 6 and 18 patients respectively. Nineteen patients died. The overall transplantation-free survival at 1, 5 and 10 years was 47, 28 and 17% respectively. CONCLUSIONS: Budd-Chiari syndrome is a rare disorder; the mean age-standardised incidence and prevalence rates in Sweden in 1990-2001 were calculated to be 0.8 per million per year and 1.4 per million inhabitants respectively. The presence of a myeloproliferative disorder was a common aetiological factor in our cohort and about half of the patients had a multifactorial aetiology. The transplantation-free survival was poor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- Gastroenterology
- Gastroenterologi
- Medicine
- Medicin
- hepatic vein thrombosis
- Budd-Chiari syndrome
- epidemiology
- risk factors
- prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Rajani, Rupesh
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Melin, Tor
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Björnsson, Einar
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Broomé, Ulrika
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Sangfelt, Per
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Danielsson, Åke
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Gustavsson, Ande ...
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Grip, Olof
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Svensson, Hans
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Lööf, Lars
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Wallerstedt, Sve ...
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Almer, Sven
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Liver internatio ...
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Örebro universitet
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Lunds universitet
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Uppsala universitet
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Linköpings universitet