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- Sotres, Javier, et al.
(författare)
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AFM-based friction force spectroscopy : a novel methodology for the study of the strength and lateral diffusion of proteinaceous films
- 2012
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Ingår i: Proteins at Interfaces III State of the Art. - Washington, DC : American Chemical Society (ACS). - 9780841227972 - 9780841227965 ; , s. 129-151
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- We present a novel methodology for the study of proteinaceous films based on the friction force spectroscopy operation mode of the atomic force microscope. It provides information both on the strength at the nanoscale level and on the lateral diffusion properties of these systems. The usefulness of the data generated by this methodology are shown through its application to the study of different types of monolayers of model proteins, as well as to the study of the more complex and heterogeneous salivary films.
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- Sotres, Javier, et al.
(författare)
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Friction Force Spectroscopy of β- and κ-casein monolayers
- 2011
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 27:3, s. 981-992
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Tidskriftsartikel (refereegranskat)abstract
- Friction force spectroscopy (FFS) has been applied to study the tribological properties of β- and κ-casein layers on hydrophobic substrates in aqueous solutions. Nanometer-sized imaging tips were employed. This allowed exerting and determining the high pressures needed to remove the layers, and registering the topographic evolution during this process. Both β- and κ-casein layers showed similar and not particularly high initial frictional responses (friction coefficient of ~1 when measure with a silicon nitride tip). The pressures needed to remove the layers were of the same order of magnitude for both proteins, ~1e8 Pa, but slightly higher for those composed of β-casein. The technique has also shown to be useful in studying the two-dimensional lateral diffusion of the proteins and the wear on the layers they form.
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