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Träfflista för sökning "WFRF:(Syk Ingvar) ;spr:eng;pers:(Madhi Raed)"

Sökning: WFRF:(Syk Ingvar) > Engelska > Madhi Raed

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1.
  • Al-Haidari, Amr, et al. (författare)
  • MiR-155-5p controls colon cancer cell migration via post-transcriptional regulation of Human Antigen R (HuR)
  • 2018
  • Ingår i: Cancer Letters. - : Elsevier BV. - 0304-3835. ; 421, s. 145-151
  • Tidskriftsartikel (refereegranskat)abstract
    • Colorectal cancer (CRC) is the third most common cancer and a significant cause of cancer-related deaths worldwide. Metastasis is the worst prognostic factor for patients with CRC. HuR (ELAVL1) is overexpressed in CRC and has been reported to promote colon cancer growth by targeting RNA in the cell cytoplasm. Herein, the role of miR-155-5p in regulating HuR expression and cell migration was examined in colon cancer cells. MiR-155-5p knockdown in serum-starved colon cancer cells decreased both colon cancer cell chemotaxis and cytoplasmic expression of HuR. Bioinformatics analysis predicted two putative binding sites in the AU-rich elements (AREs) at the 3′-UTR of HuR mRNA. MiR-155-5p binding to HuR was verified using specific target site blockers and functionally validated by use of RNA immunoprecipitation assays, showing that miR-155-5p-dependent regulation of HuR expression is mediated by AREs. Targeting AREs with a specific blocker inhibited colon cancer cell migration. Taken together, these novel findings demonstrate that AREs mediate miR-155-5p positive regulation of HuR mRNA levels and translation as well as migration in colon cancer cells, suggesting that targeting miR-155-5p and/or Hur might be useful therapeutic strategies against colon cancer metastasis.
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2.
  • Algaber, Anwar, et al. (författare)
  • MicroRNA-340-5p inhibits colon cancer cell migration via targeting of RhoA
  • 2020
  • Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1, s. 16934-16934
  • Tidskriftsartikel (refereegranskat)abstract
    • Colon cancer is the third most common cancer and a significant cause of cancer-related deaths worldwide. Metastasis is the most insidious aspect of cancer progression. Convincing data suggest that microRNAs (miRs) play a key function in colon cancer biology. We examined the role of miR-340-5p in regulating RhoA expression as well as cell migration and invasion in colon cancer cells. Levels of miR-340-5p and RhoA mRNA varied inversely in serum-free and serum-grown HT-29 and AZ-97 colon cancer cells. It was found transfection with miR-340-5p not only decreased expression of RhoA mRNA and protein levels in HT-29 cells but also reduced colon cancer cell migration and invasion. Bioinformatics analysis predicted one putative binding sites at the 3'-UTR of RhoA mRNA. Targeting this binding site with a specific blocker reversed mimic miR-340-5p-induced inhibition of RhoA activation and colon cancer cell migration and invasion. These novel results suggest that miR-340-5p is an important regulator of colon cancer cell motility via targeting of RhoA and further experiments are warranted to evaluate the role of miR-340-5p in colon cancer metastasis.
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  • Resultat 1-2 av 2
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tidskriftsartikel (2)
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refereegranskat (2)
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Thorlacius, Henrik (2)
Syk, Ingvar (2)
Al-Haidari, Amr (2)
Algaber, Anwar (2)
Madhi, Raed (2)Ta bort avgränsningen
Rahman, Milladur (1)
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Lunds universitet (2)
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Engelska (2)Ta bort avgränsningen
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

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