SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Syvanen Ann Christine) ;lar1:(uu)"

Sökning: WFRF:(Syvanen Ann Christine) > Uppsala universitet

  • Resultat 1-10 av 11
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Fuchsberger, Christian, et al. (författare)
  • The genetic architecture of type 2 diabetes
  • 2016
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 536:7614, s. 41-47
  • Tidskriftsartikel (refereegranskat)abstract
    • The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Hamberg, U, et al. (författare)
  • Human kininogen from Cohns Fraction IV : comparisons of antigenicity and multiple forms
  • 1979
  • Ingår i: Advances in Experimental Medicine and Biology. - 0065-2598 .- 2214-8019. ; 120B, s. 173-183
  • Tidskriftsartikel (refereegranskat)abstract
    • Kininogen was isolated from Cohns fraction IV by DEAE-chromatography, gel filtration and ammonium sulphate precipitation. Immunologically pure kininogen was prepared by removal of protein impurities using specific immunoadsorbents with Sepharose-bound antibody. Anti-kininogen serum was raised in rabbits against the pure antigen. Comparison with anti-kininogen sera prepared with the biologically active LMW antigen from whole plasma suggested antigenic identity by double immunodiffusion analysis. The Cohn-kininogen was shown to contain mainly two components (85%) in about equal amounts focusing with peaks at pI 4.2 (42%) and pI 4.3 (43%). These represent apparently structurally altered forms of the native plasma kininogen focusing at pI 4.5-4.6 (54%), which occurred as a minor component (13%).
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 11
Typ av publikation
tidskriftsartikel (10)
annan publikation (1)
Typ av innehåll
övrigt vetenskapligt/konstnärligt (7)
refereegranskat (4)
Författare/redaktör
Siegbahn, Agneta (2)
Forestier, Erik (2)
Axelsson, Tomas (2)
Rönnblom, Lars (2)
Berglund, Lars (1)
Larsson, Rolf (1)
visa fler...
Boeing, Heiner (1)
Rolandsson, Olov (1)
Gustafsson, Mats (1)
Nilsson, Peter (1)
Lyssenko, Valeriya (1)
Tuomi, Tiinamaija (1)
DeFronzo, Ralph A. (1)
Groop, Leif (1)
Cavelier, Lucia (1)
Alexsson, Andrei (1)
Fadista, Joao (1)
Eriksson, Niclas (1)
Salomaa, Veikko (1)
Katus, Hugo A (1)
Lind, Lars (1)
Abrahamsson, Jonas (1)
Jonsson, Olafur G. (1)
Palle, Josefine (1)
Eloranta, Maija-Leen ... (1)
Landegren, Ulf (1)
Lannfelt, Lars (1)
Nordmark, Gunnel (1)
Melander, Olle (1)
Deloukas, Panos (1)
Freedman, Barry I. (1)
Gustafsson, Mats G. (1)
Isaksson, Anders (1)
Huyghe, Jeroen R. (1)
Palli, Domenico (1)
Franks, Paul W. (1)
Navarro, Carmen (1)
Wareham, Nicholas J. (1)
Im, Hae Kyung (1)
Wadelius, Claes (1)
Stancáková, Alena (1)
Kuusisto, Johanna (1)
Isomaa, Bo (1)
Laakso, Markku (1)
Rosengren, Anders (1)
McCarthy, Mark I (1)
Hagström, Emil (1)
Ladenvall, Claes (1)
Kravic, Jasmina (1)
Bork-Jensen, Jette (1)
visa färre...
Lärosäte
Uppsala universitet  (11)Ta bort avgränsningen
Umeå universitet (2)
Karolinska Institutet (2)
Lunds universitet (1)
Sveriges Lantbruksuniversitet (1)
Språk
Engelska (11)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (6)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy