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Träfflista för sökning "WFRF:(Törngren Therese) ;pers:(Westerdahl Johan)"

Sökning: WFRF:(Törngren Therese) > Westerdahl Johan

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  • Måsbäck, Anna, et al. (författare)
  • Clinical and histopathological features of malignant melanoma in germline CDKN2A mutation families
  • 2002
  • Ingår i: Melanoma Research. - 0960-8931. ; 12:6, s. 549-557
  • Tidskriftsartikel (refereegranskat)abstract
    • Primary cutaneous malignant melanomas (CMMs) from 26 individuals belonging to nine families with an identified CDKN2A mutation were clinically and histopathologically compared with 78 matched CMM controls and with a population-based series of CMMs (n=667). All tumours were histopathologically re-examined. CDKN2A-associated cases were significantly less invasive compared with the matched controls, with an adjusted odds ratio (adjOR) of 2.9 and a 95% confidence interval (CI) of 1.0-8.1 (P=0.04). According to the odds ratio (OR) values, CDKN2A-associated cases seemed to have tumours more often located on the head and neck (adjOR 2.9, 95% CI 0.6-13.7), with less inflammation (adjOR 0.7, 95% CI 0.3-1.8) and regression (adjOR 0.6, 95% CI 0.2-1.8) but more frequent histological ulceration (adjOR 1.9, 95% CI 0.6-5.8). In comparison with the population-based material, CDKN2A-associated cases were significantly younger at diagnosis (crude OR 3.5, 95% CI 1.6-7.5, divided at 50 years) and had less regressive reaction in their tumours (crude OR 0.355 95% CI 0.2-0.8). No significant differences were seen for tumour thickness between the different groups. On multivariate analysis, the overall survival was significantly worse for thicker tumours and older age (P=0.04 for both). To our knowledge this is the first description of the histopathological features of CMMs from families with mutations in the CDKN2A gene.
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Westerdahl, Joha... (2)Ta bort avgränsningen
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Törngren, Therese (2)
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