| 1. |
- Kristan, Matej, et al.
(författare)
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The Sixth Visual Object Tracking VOT2018 Challenge Results
- 2019
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Ingår i: Computer Vision – ECCV 2018 Workshops. - Cham : Springer Publishing Company. - 9783030110086 - 9783030110093 ; , s. 3-53
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2018 is the sixth annual tracker benchmarking activity organized by the VOT initiative. Results of over eighty trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis and a “real-time” experiment simulating a situation where a tracker processes images as if provided by a continuously running sensor. A long-term tracking subchallenge has been introduced to the set of standard VOT sub-challenges. The new subchallenge focuses on long-term tracking properties, namely coping with target disappearance and reappearance. A new dataset has been compiled and a performance evaluation methodology that focuses on long-term tracking capabilities has been adopted. The VOT toolkit has been updated to support both standard short-term and the new long-term tracking subchallenges. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website (http://votchallenge.net).
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| 2. |
- Webb, Ryan, et al.
(författare)
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Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus
- 2009
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 60:4, s. 1076-1084
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Both genetic and epigenetic factors play an important role in the pathogenesis of lupus. The aim of this study was to examine methyl-CpG-binding protein 2 gene (MECP2) polymorphisms in a large cohort of patients with lupus and control subjects, and to determine the functional consequences of the lupus-associated MECP2 haplotype. METHODS: We genotyped 18 single-nucleotide polymorphisms within MECP2, located on chromosome Xq28, in a large cohort of patients with lupus and control subjects of European descent. We studied the functional effects of the lupus-associated MECP2 haplotype by determining gene expression profiles in B cell lines in female lupus patients with and those without the lupus-associated MECP2 risk haplotype. RESULTS: We confirmed, replicated, and extended the genetic association between lupus and genetic markers within MECP2 in a large independent cohort of lupus patients and control subjects of European descent (odds ratio 1.35, P = 6.65 x 10(-11)). MECP2 is a dichotomous transcription regulator that either activates or represses gene expression. We identified 128 genes that are differentially expressed in lupus patients with the disease-associated MECP2 haplotype; most ( approximately 81%) were up-regulated. Genes that were up-regulated had significantly more CpG islands in their promoter regions compared with genes that were down-regulated. Gene ontology analysis using the differentially expressed genes revealed significant association with epigenetic regulatory mechanisms, suggesting that these genes are targets for MECP2 regulation in B cells. Furthermore, at least 13 of the 104 up-regulated genes are regulated by interferon. The disease-risk MECP2 haplotype was associated with increased expression of the MECP2 transcription coactivator CREB1 and decreased expression of the corepressor histone deacetylase 1. CONCLUSION: Polymorphism in the MECP2 locus is associated with lupus and, at least in part, contributes to the interferon signature observed in lupus patients.
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| 3. |
- Xin, Tongzheng, et al.
(författare)
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Phase transformations in an ultralight BCC Mg alloy during anisothermal ageing
- 2022
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Ingår i: Acta Materialia. - : PERGAMON-ELSEVIER SCIENCE LTD. - 1359-6454 .- 1873-2453. ; 239
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Tidskriftsartikel (refereegranskat)abstract
- Mg-Li-Al alloys with a body-centred cubic (BCC) structure can exhibit exceptional specific strengths in combination with excellent ductility and corrosion resistance. In general, the strength of these alloys is very sensitive to the processing temperature due to the occurrence of various phase transformations. Although different phases have been identified in these alloys, their corresponding transformation mechanisms and unique role played in controlling the mechanical properties have never been studied in depth. In this work, we identified the phase transformation sequence by in-situ synchrotron X-ray diffraction. Moreover, we investigated the evolution of precipitation and their morphology using transmission and scanning electron microscopy, together with simulations based on the phase field modelling and first-principles calculations. Phase transformation sequence of Al-rich zone?->?theta (D0(3)(-)Mg(3)Al)?->?AlLi was confirmed during anisothermal ageing. A braided structure resulting from spinodal decomposition was found to be the optimized microstructure for achieving the peak strength. Nanocrystalline alpha-Mg phase at the interface between theta and the matrix was identified as the main reason for softening in the alloy. The core-shell model for theta?->?AlLi transformation is observed and verified. Our findings deepen the understanding of BCC Mg-Li-Al alloys and pave a pathway to develop new generation of ultralight alloys with stronger strength and better stability. (C) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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