| 1. |
- Cederfeldt, Marie, 1957, et al.
(author)
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A longitudinal study of cognitive impairments in relation to activities in daily life
- 2009
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In: AT-FORUM, Äldres vardag, 6-8 maj-2009, Älvsjömässan i Stockholm.
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Conference paper (peer-reviewed)abstract
- Objective: To examine whether there were any differences in recovery in performance of personal activities of daily living (P-ADL) in relation to cognitive impairments pre- and poststroke from discharge to 6 and 12 months in elderly persons. Methods: Forty-five elderly persons after stroke were assessed at discharge from the hospital at 6 and at 12 months. A questionnaire was used to evaluate the person´s prestroke cognitive status. P-ADL was assessed with the Barthel Index. The Mini Mental State Examination and neuropsychological tests were used to measure cognitive functions. Results: Persons with cognitive impairments before and after stroke did not improve in P-ADL from the acute phase until 6 and 12 months, while persons with intact cognition pre- and poststroke did. Conclusion: Since cognitive problems pre- and poststroke hinder recovery in P-ADL, it is important to be aware of the connection between cognitive impairment and activity limitations in planning the optimal rehabilitation. Key words: ADL, cognitive dysfunction, elderly, longitudinal, prestroke, stroke
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| 2. |
- Cederfeldt, Marie, 1957, et al.
(author)
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En prospektiv studie om kognitiv nedsättning i relation till aktiviteter i det dagliga livet - Göteborgs Kognitiva Stroke Studie för Äldre
- 2008
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In: Läkarstämman i Göteborg 2008.
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Conference paper (peer-reviewed)abstract
- Det saknas studier om hur kognitiva nedsättningar pre-och poststroke påverkar vardagsaktiviteterna för äldre personer efter ett år. Syftet var att undersöka om det var någon skillnad i P-ADL från akutskedet till 12 månader hos äldre personer efter stroke med eller utan kognitiva nedsättningar pre- och poststroke. Äldre personer drabbade av stroke (n=45) inkluderades. Bedömningar utfördes vid utskrivning, 6 och 12 månader. Medianålderna var 77 år. Åstrands frågeformulär användes för att intervjua anhöriga om patientens kognitiva status prestroke. DSM-III användes också för diagnosen prestroke demens. Bartel Index användes för att bedöma P-ADL. Mini Mental State Examination (MMSE) och ett neuropsykologiskt test batteri användes för att bedöma kognitiv funktion. Resultat: Ej publicerat än
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| 3. |
- Cederfeldt, Marie, 1957, et al.
(author)
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Influence of cognition on personal activities of daily living (P-ADL) in
- 2007
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In: Nordisk konferens för arbetsterapeuter i Stockholm 2007.
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Conference paper (peer-reviewed)abstract
- This study examines how prestroke dementia and cognitive dysfunction after stroke influence the personal activities of daily living (P-ADL) in elderly patients in the acute phase after stroke. Elderly patients (n = 60) referred to geriatric rehabilitation were included. Assessments were carried out at admission and evaluated at discharge from the geriatric ward. The median age of the group was 77 years. Åstrand’s questionnaire was used to interview a close relative about the patient’s prestroke cognitive status. P-ADL was assessed with the Barthel Index (BI). The Mini Mental State Examination (MMSE) and a neuropsychological test battery were used to measure cognitive functions. Analyses were made using non-parametrical methods. In the acute phase after stroke, neither the presence of prestroke dementia nor the cognitive status after stroke onset among these elderly patients influenced P-ADL at admission or at discharge. Prestroke dementia and cognitive dysfunction’s were found to be common after stroke onset, however this did not have any impact on dependence in P-ADL in these elderly patients at admission or at discharge.
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| 4. |
- Cederfeldt, Marie, 1957, et al.
(author)
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Influence of cognition on personal activities of daily living (P-ADL) in the acute phase - The Gothenburg Cognitive Stroke Study in Elderly
- 2006
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In: Läkarstämman i Göteborg 2006.
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Conference paper (peer-reviewed)abstract
- This study examines how prestroke dementia and cognitive dysfunction after stroke influence the personal activities of daily living (P-ADL) in elderly patients in the acute phase after stroke. Elderly patients (n = 60) referred to geriatric rehabilitation were included. Assessments were carried out at admission and evaluated at discharge from the geriatric ward. The median age of the group was 77 years. Åstrand’s questionnaire was used to interview a close relative about the patient’s prestroke cognitive status. P-ADL was assessed with the Barthel Index (BI). The Mini Mental State Examination (MMSE) and a neuropsychological test battery were used to measure cognitive functions. Analyses were made using non-parametrical methods. In the acute phase after stroke, neither the presence of prestroke dementia nor the cognitive status after stroke onset among these elderly patients influenced P-ADL at admission or at discharge. Prestroke dementia and cognitive dysfunction’s were found to be common after stroke onset, however this did not have any impact on dependence in P-ADL in these elderly patients at admission or at discharge.
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| 5. |
- Cederfeldt, Marie, 1957, et al.
(author)
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Influence of cognition on personal activities of daily living (P-ADL) in the acute phase: the Gothenburg Cognitive Stroke Study in Elderly.
- 2009
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In: Archives of gerontology and geriatrics. - : Elsevier BV. - 1872-6976 .- 0167-4943. ; 49:1, s. 118-22
-
Journal article (peer-reviewed)abstract
- This study examines how prestroke dementia and cognitive dysfunction after stroke influence the personal activities of daily living (P-ADL) in elderly patients in the acute phase after stroke. Elderly stroke patients (n=60) referred to geriatric rehabilitation were included. Assessments were carried out at admission and evaluated at discharge from the geriatric ward. The median age of the group was 77 years. Astrand's questionnaire was used to interview a close relative about the patient's prestroke cognitive status. P-ADL was assessed with the Barthel Index (BI). The Mini Mental State Examination (MMSE) and a neuropsychological test battery were used to measure cognitive functions. Analyses were made using non-parametrical methods. In the acute phase after stroke, neither the presence of prestroke dementia nor the cognitive status after stroke onset among these elderly patients influenced P-ADL at admission or at discharge. Prestroke dementia and cognitive dysfunction's were found to be common after stroke onset, however this did not have any impact on dependence in P-ADL in these elderly patients at admission or at discharge.
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| 6. |
- Cederfeldt, Marie, 1957, et al.
(author)
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Recovery in personal care related to cognitive impairment before and after stroke - a one-year follow-up
- 2010
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In: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 122:6, s. 430-437
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Journal article (peer-reviewed)abstract
- Abstract Objective: To examine whether there were any differences in the recovery in performance of personal activities of daily living (P-ADL) in elderly persons in relation to cognitive impairments pre- and poststroke from discharge to 6 and 12 months in elderly persons. Methods: Forty-five elderly persons after stroke were assessed at discharge from hospital and at 6 and at 12 months after stroke onset. A questionnaire posed to the next of kin was used to evaluate the person´s pre- and poststroke cognitive status. P-ADL was assessed with the Barthel Index. The Mini Mental State Examination and neuropsychological tests were used to measure cognitive functions after stroke. The National Institute of Health Stroke Scale was used to measure neurological deficits. Results: Persons with cognitive impairments before and after stroke did not improve in P-ADL from the acute phase until 6 and 12 months, while persons with intact cognition pre- and post stroke did. Conclusion: Since cognitive problems pre- and poststroke hinder recovery in P-ADL, it is important to understand the connection between cognitive impairment and activity limitations when planning the optimal rehabilitation, which could include special compensation strategies, learnt by the patients, cognitive assistive devices and/or appropriate personal support trained in meaningful activities in daily life in their natural environment.
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| 7. |
- Gjertsson, Inger, 1962, et al.
(author)
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Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance.
- 2002
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In: Clinical and experimental immunology. - 0009-9104. ; 130:3, s. 409-14
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Journal article (peer-reviewed)abstract
- Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions. To investigate the role of IL-10 in S. aureus-induced arthritis and sepsis, Balb/c mice, intact or defective with respect to IL-10 gene were intravenously inoculated with bacteria. IL-10-/- mice develop a more frequent and destructive arthritis compared to their congeneic controls. The mechanisms regulating such outcome may be due not only to the anti-inflammatory properties of IL-10 but also, directly or indirectly, to antibacterial features of this molecule. Indeed, inoculation of staphylococci to IL-10-/- mice resulted in higher bacterial load in blood and kidneys compared to congeneic controls. Altogether our data indicate that IL-10 is essential for efficient elimination of bacteria and thereby for protection against septic arthritis.
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| 8. |
- Gutiérrez Pérez, Cristina, 1972, et al.
(author)
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High frequency of cognitive dysfunction before stroke in the elderly
- 2011
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In: International Journal of Geriatric Psychiatry. - : Wiley. - 1099-1166 .- 0885-6230. ; 26:6, s. 622-629
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Journal article (peer-reviewed)abstract
- Objectives We examined cognitive functions before and in acute phase of stroke studying frequency and profile of cognitive impairment and relationships between cognitive status.MethodsSeventy-four patients with early phase after stroke and 49 healthy controls were included and examined using the Mini-Mental State Examination (MMSE) and a battery of neuropsychological tests. Cognitive status before stroke-onset was investigated using Cognitive Impairment Questionnaire.ResultsCognitive impairments were present in 96% of patients after stroke onset using the battery of neuropsychological tests and in 39% of patients using the MMSE, but in only 9% of controls. Seventy-six percent exhibited reduced executive function and 75% reduced psychomotor tempo. Cognitive dysfunction was present in 52% before stroke onset without any impact on the frequency of impairment in the various cognitive areas in early phase after stroke.ConclusionsCognitive impairment is frequent before the onset of stroke among older people and may partially explain the very high frequency of cognitive impairment observed after stroke onset.
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| 9. |
- Pahlman, Ulrika, et al.
(author)
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Cognitive Dysfunction and Physical Activity After Stroke: The Gothenburg Cognitive Stroke Study in the Elderly
- 2012
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In: Journal of Stroke & Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057. ; 21:8, s. 652-658
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Journal article (peer-reviewed)abstract
- This study explored the association between cognitive and executive dysfunction and level of physical activity 1 year after stroke. Cognition before stroke and cognitive and executive function in the acute phase and at 1 year after stroke were assessed in 74 subjects. Physical activity was assessed at 1 year after stroke. Factors that appeared to predict low level of physical activity at 1 year after stroke were impaired global cognition before stroke, visual neglect and impaired logical deductive ability in the acute phase, and impaired global cognition, executive function, and visual memory 1 year after stroke. Our findings underscore the importance of identifying stroke patients with impaired cognitive and executive function who are at risk for developing inactivity.
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| 10. |
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