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Träfflista för sökning "WFRF:(The Swedish Childhood Diabetes Study Group) "

Sökning: WFRF:(The Swedish Childhood Diabetes Study Group)

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1.
  • Shin, JH, et al. (författare)
  • IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5
  • 2007
  • Ingår i: Genes Immun. - 1466-4879 (Print). ; 8:6, s. 503-12
  • Tidskriftsartikel (refereegranskat)abstract
    • In a large case-control study of Swedish incident type I diabetes patients and controls, 0–34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 times 10-13) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 times 10-5) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease.
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2.
  • Resic-Lindehammar, Sabina, et al. (författare)
  • Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
  • 2008
  • Ingår i: Acta Diabetologica. - Springer Milan. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-235
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1–18-year-old patients with type 1 diabetes newly diagnosed in 1986–1987 (<em>n</em> = 430), 1996–2000 (<em>n</em> = 342) and in 2003–2005 (<em>n</em> = 171). We tested the hypothesis that the <em>HLA DQ</em> genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for <em>DQ A1</em>* and <em>B1</em>* alleles. The most common type 1 diabetes HLA <em>DQA1*-B1*</em>genotype <em>0501-0201/0301-0302</em> was 36% (153/430) in 1986–1987 and 37% (127/342) in 1996–2000, but decreased to 19% (33/171) in 2003–2005 (<em>P</em> &lt; 0.0001). The <em>0501-0201/0501-0201</em> genotype increased from 1% in 1986–1987 to 7% in 1996–2000 (<em>P</em> = 0.0047) and to 5% in 2003–2005 (<em>P</em> &gt; 0.05). This study in 1–18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.</p>
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