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IA-2 autoantibodies...
IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5
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- Shin, J. H. (author)
- Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada
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- Janer, M. (author)
- Institute for Systems Biology, Seattle, WA, USA
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- McNeney, B. (author)
- Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada
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- Blay, S. (author)
- Karolinska Institutet
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- Deutsch, K. (author)
- Institute for Systems Biology, Seattle, WA, USA
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Sanjeevi, C. B. (author)
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- Kockum, I. (author)
- Karolinska Institutet
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Graham, J. (author)
- Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada
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- Arnqvist, H. (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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Björck, E. (author)
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Eriksson, J. (author)
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Nystrom, L. (author)
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Ohlson, L. O. (author)
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Schersten, B. (author)
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Östman, J. (author)
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Aili, M. (author)
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Baath, L. E. (author)
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Carlsson, E. (author)
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Edenwall, H. (author)
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- Forsander, Gun, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Granström, B. W. (author)
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Gustavsson, I. (author)
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Hanas, R. (author)
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Hellenberg, L. (author)
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Hellgren, H. (author)
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Holmberg, E. (author)
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Hornell, H. (author)
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Ivarsson, S. A. (author)
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Johansson, C. (author)
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Jonsell, G. (author)
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Kockum, K. (author)
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Lindblad, B. (author)
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Lindh, A. (author)
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- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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Myrdal, U. (author)
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Neiderud, J. (author)
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Segnestam, K. (author)
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Sjöblad, S. (author)
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Skogsberg, L. (author)
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Stromberg, L. (author)
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Stahle, U. (author)
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Thalme, B. (author)
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Tullus, K. (author)
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- Tuvemo, T (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson
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Wallensteen, M. (author)
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Westphal, O. (author)
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- Aman, J. (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson
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Diabetes Incidence in Sweden Study Group, The (author)
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Swedish Childhood Diabetes Study Group, The (author)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2007
- 2007
- English.
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In: Genes Immun. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:6, s. 503-12
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Adolescent
- Adult
- Autoantibodies/blood/*immunology
- Case-Control Studies
- Child
- Child
- Preschool
- Diabetes Mellitus
- Type 1/*genetics/*immunology/metabolism
- Female
- GTP-Binding Proteins/*genetics/metabolism
- Humans
- Infant
- Infant
- Newborn
- Male
- Polymorphism
- Single Nucleotide
- Sweden
- Adolescent
- MEDICINE
- polyadenylation signal
- IA-2 autoantibodies
- GIMAP5
- type I diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Shin, J. H.
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Janer, M.
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McNeney, B.
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Blay, S.
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Deutsch, K.
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Sanjeevi, C. B.
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show more...
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Kockum, I.
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Lernmark, Åke
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Graham, J.
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Arnqvist, H.
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Björck, E.
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Eriksson, J.
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Nystrom, L.
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Ohlson, L. O.
-
Schersten, B.
-
Östman, J.
-
Aili, M.
-
Baath, L. E.
-
Carlsson, E.
-
Edenwall, H.
-
Forsander, Gun, ...
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Granström, B. W.
-
Gustavsson, I.
-
Hanas, R.
-
Hellenberg, L.
-
Hellgren, H.
-
Holmberg, E.
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Hornell, H.
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Ivarsson, S. A.
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Johansson, C.
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Jonsell, G.
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Kockum, K.
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Lindblad, B.
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Lindh, A.
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Ludvigsson, John ...
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Myrdal, U.
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Neiderud, J.
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Segnestam, K.
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Sjöblad, S.
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Skogsberg, L.
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Stromberg, L.
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Stahle, U.
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Thalme, B.
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Tullus, K.
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Tuvemo, T
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Wallensteen, M.
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Westphal, O.
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Aman, J.
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Diabetes Inciden ...
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Swedish Childhoo ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Genes Immun
- By the university
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University of Gothenburg
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Uppsala University
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Linköping University
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Lund University
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Karolinska Institutet