| 1. |
- Albrektsen, G., et al.
(författare)
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Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromso Study 1979-2012
- 2017
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Ingår i: Data in Brief. - : Elsevier BV. - 2352-3409. ; 13, s. 779-784
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Tidskriftsartikel (refereegranskat)abstract
- The data presented in this article relate to the research article entitled "Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromso Study 1979-2012" (Albrektsen et al., 2017) [1]. Data quantify the gender differences in the risk of myocardial infarction (MI) in terms of incidence rate ratios (IRR), in subgroups defined by serum lipids, blood pressure and smoking among persons aged 35-54 years, 55-74 years and 75-94 years, respectively. Data also describe the age- and gender-specific linear associations with the coronary heart disease (CHD) risk factors. IRRs for combined categories of age, gender and a CHD risk factor, with each category compared to the same reference group, are also shown. IRRs were calculated as estimates of relative risk in Poisson regression analyses of person-years at risk. Among 33,859 individuals at risk, a total of 622,1308 and 816 were diagnosed with Ml at ages 35-54, 55-74 and 75-94 years, respectively. (C) 2017 The Authors. Published by Elsevier Inc.
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| 2. |
- Albrektsen, G., et al.
(författare)
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Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromso Study 1979-2012
- 2017
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150. ; 261, s. 52-59
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Overall, men have roughly twice the risk of myocardial infarction (MI) compared to women, but what causes this contrast is unclear. Identification of subgroups where the gender contrast in risk is particularly low or high, may provide new insight. In the search for such subgroups, we focus on gender-specific effects of established coronary heart disease (CHD) risk factors. Heterogeneity across age groups is also explored. Methods: Population-based prospective study from Tromso, Norway, comprising 33,859 individuals (51% women); 2746 individuals (854 women) received a diagnosis of MI during follow-up at ages 35-94 years. Incidence rate ratios (IRR) were calculated as estimates of relative risk in Poisson regression analyses. Results: The association between total cholesterol and risk of MI was stronger for men than women, and IRR for men vs. women accordingly increased with increasing cholesterol, but the risk was higher for men in all subgroups (IRR in range 1.63-3.27), except among older people with low cholesterol levels. The adverse effect of increasing blood pressure (BP) was stronger for women, and IRR for gender diminished with increasing systolic (from 3.90 to 1.38) and diastolic BP (from 2.87 to 1.54). The gender contrast in risk was also substantially reduced in smokers >= 75 years. Associations with high-density lipoprotein cholesterol (HDL-C) did not differ between genders. Conclusions: Gender heterogeneity in associations with total cholesterol but not HDL-C indicates gender differences in associations with non-HDL-C. The stronger association with BP in women may relate to more severe hypertension-induced left ventricular hypertrophy. (C) 2017 Elsevier B.V. All rights reserved.
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| 3. |
- Njolstad, I., et al.
(författare)
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The TromsO study 1974-2016: 40 years of cardiovascular research
- 2016
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Ingår i: Scandinavian Cardiovascular Journal. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 50:5-6, s. 276-281
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Tidskriftsartikel (refereegranskat)abstract
- The rapid increase of coronary heart disease mortality in Northern Norway during 1951-1970 was why the newly established University of TromsO decided to start a study to identify major operating cardiovascular risk factors. The first TromsO survey in 1974 suggested that the relatively high cardiovascular mortality was associated with elevated cholesterol levels and high prevalence of smoking, while high-density-lipoprotein-cholesterol (HDL-C) was identified as a preventive factor. After 1974, six more surveys including both genders (aged 20-89 years) were undertaken. The second survey (1979) revealed the cholesterol increasing effect of coffee. Echocardiographic examinations, ECG, and ultrasound of carotid arteries were introduced in later surveys, and intervention studies were established. Repeated carotid measurements showed that inflammation was involved in novel plaque formation, while HDL-C was protective. Moderate physical activity protected against atrial fibrillation but hard exercise increased the risk. Obesity, hypertension and smoking increased the risk of aortic stenosis, and diastolic dysfunction predicted development of atrial fibrillation. Dilated left atria predicted stroke, especially for individuals without known atrial fibrillation. Total cholesterol, blood pressure and smoking declined after 1974, corresponding to the subsequent decline in coronary heart disease mortality. Reduced incidence accounted for 40% of the mortality decline, while a substantial reduction in case fatality explained the remaining 60%.
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