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- Duchesne, Annie, et al.
(författare)
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Hippocampal Integrity in Swedish Women with Bilateral Salpingo-oophorectomy prior to Natural Menopause
- 2017
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Ingår i: Alzheimer's Association International Conference. - Hoboken, NJ, United States : John Wiley & Sons. ; , s. 1084-1084
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Konferensbidrag (refereegranskat)abstract
- Background:Oophorectomy prior to natural menopause places women at increased risk of dementia and/or Alzheimer's disease (AD). Recent findings from our Toronto group reveal a negative association between oophorectomy prior to natural menopause and verbal memory in middle-aged women. We have also found a positive association between estrogen levels and verbal recall. Taken together, these findings support previous work suggesting that oophorectomy, leading to reduced levels of estrogens, is detrimental to verbal memory. Estrogen withdrawal has also been correlated with reduced hippocampal volume and reduced hippocampal resting functional connectivity (FC), both early AD biomarkers. Thus, we wondered whether hippocampal volume and resting functional connectivity would be reduced in women with oophorectomy prior to natural menopause.Methods:In order to determine this, we recruited healthy, Swedish women (30 and 55 years) with the breast cancer mutation gene (BRCA1/2) who had a bilateral salpingo-oophorectomy (BSO) prior to natural menopause. Most women were between 1–7 years post-BSO and at least 6 months post-cancer treatment or had not had cancer. Using magnetic resonance imaging (3T scanner, Phillips) we measured functional resting state over 10 minutes and volume with a T1 structural scan. We collected urine in order to determine estrogen and progesterone levels.Results:We hypothesize that women with BSO will have structural and functional hippocampal changes compared to age matched controls. We predict that women with BSO will have smaller hippocampal volumes and reduced hippocampal FC. We further predict that lower levels of estrogens will correlate with these brain changes. Neuroimaging and endocrine analyses are ongoing.Conclusions:AD affects women in greater numbers and one possibility is that oophorectomy prior to natural menopause contributes to these numbers. Determining whether or not these women show the earliest biomarkers for AD will increase our understanding of estrogen withdrawal's effects on brain health as well as its importance for healthy brain aging. Importantly, results of this study will inform us on the early brain changes in a population at greater risk of AD.
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- Nordlind, Klas, et al.
(författare)
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Effect of chronic mild stress on skin and brain in the NC/Nga atopic-like mouse
- 2011
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Ingår i: JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol 131 Issue S2 (September 2011). - : Nature Publishing Group. ; , s. S116-S116
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Konferensbidrag (refereegranskat)abstract
- Atopic eczema is often worsened by stress. We have studied the effect of chronic mild stress in the atopic-like NC/Nga mouse strain. The mice were subjected to chronic mild stress for 12 weeks and eczema was induced by applying a mite antigen (Dermatophagoides pteronyssinus) on the ears for the last 4 weeks. The mice were divided into stressed eczematous, non-stressed eczematousand stressed control groups. Serum corticosterone levels were determined at the endpoint of the experiment. The biopsies from skin and brain have been analyzed using immunohistochemistry and RT-PCR. The diameter of the ears was larger in the stressed eczematous group compared to the other groups. Moreover, the corticosterone levels were significantly lower in the stressedeczematous group. The neuromediators being studied are serotonin, its transporter protein, as well as its receptors, and the tachykinin substance P and its receptor neurokinin-1.
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