| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Herrera-Rivero, Marisol, et al.
(författare)
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Exploring the genetics of lithium response in bipolar disorders.
- 2023
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Ingår i: Research square.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N=2,064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II.We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism.Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II.
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| 3. |
- Larson, Greger, et al.
(författare)
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Current perspectives and the future of domestication studies
- 2014
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 111:17, s. 6139-6146
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- It is difficult to overstate the cultural and biological impacts that the domestication of plants and animals has had on our species. Fundamental questions regarding where, when, and how many times domestication took place have been of primary interest within a wide range of academic disciplines. Within the last two decades, the advent of new archaeological and genetic techniques has revolutionized our understanding of the pattern and process of domestication and agricultural origins that led to our modern way of life. In the spring of 2011, 25 scholars with a central interest in domestication representing the fields of genetics, archaeobotany, zooarchaeology, geoarchaeology, and archaeology met at the National Evolutionary Synthesis Center to discuss recent domestication research progress and identify challenges for the future. In this introduction to the resulting Special Feature, we present the state of the art in the field by discussing what is known about the spatial and temporal patterns of domestication, and controversies surrounding the speed, intentionality, and evolutionary aspects of the domestication process. We then highlight three key challenges for future research. We conclude by arguing that although recent progress has been impressive, the next decade will yield even more substantial insights not only into how domestication took place, but also when and where it did, and where and why it did not.
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| 4. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Zhou Hagström, Nanna, 1993-, et al.
(författare)
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Megahertz-rate Ultrafast X-ray Scattering and Holographic Imaging at the European XFEL
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The advent of X-ray free-electron lasers (XFELs) has revolutionized fundamental science, from atomic to condensed matter physics, from chemistry to biology, giving researchers access to X-rays with unprecedented brightness, coherence, and pulse duration. All XFEL facilities built until recently provided X-ray pulses at a relatively low repetition rate, with limited data statistics. Here, we present the results from the first megahertz repetition rate X-ray scattering experiments at the Spectroscopy and Coherent Scattering (SCS) instrument of the European XFEL. We illustrate the experimental capabilities that the SCS instrument offers, resulting from the operation at MHz repetition rates and the availability of the novel DSSC 2D imaging detector. Time-resolved magnetic X-ray scattering and holographic imaging experiments in solid state samples were chosen as representative examples, providing an ideal test-bed for operation at megahertz rates. Nevertheless, our results are relevant and applicable to any other non-destructive XFEL experiments in the soft X-ray range.
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| 6. |
- Baad-Hansen, Lene, et al.
(författare)
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Reliability of intraoral quantitative sensory testing (QST) in patients with atypical odontalgia and healthy controls : a multicenter study
- 2014
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Reliability of intraoral quantitative sensory testing (QST) in patients with atypical odontalgia and healthy controls – a multicenter study The reliability of a comprehensive intraoral quantitative sensory testing (QST) protocol has not been examined systematically in patients with chronic orofacial pain. Also, the reliability of QST z-scores has not been reported. Aim of Investigation: The aim of the present multi-center study was to examine test-retest and inter-examiner reliability of intraoral QST measures in terms of absolute values and z-scores as well as within-session coefficients of variation (CV) values in patients with atypical odontalgia (AO) and healthy pain-free controls. Methods: Fourty-five AO patients and 68 healthy controls were subjected to bilateral intraoral gingival QST and unilateral extraoral QST (thenar) on three occasions (twice on one day by two different examiners and once approximately one week later by one of the examiners). Interclass correlation coefficients and kappa values for inter-examiner and test-retest reliability were computed. Results: Most of the standardized intraoral QST measures (absolute values and z-scores) showed fair to excellent inter-examiner (9-12 of 13 measures) and test-retest (7-11 of 13 measures) reliability. Furthermore, no robust differences in reliability measures or within-session variability (CV) were detected between AO patients and the healthy reference group. Conclusions: These reliability results in chronic orofacial pain patients support earlier suggestions based on data from healthy subjects that intraoral QST (absolute values as well as z-scores) is sufficiently reliable for use as a part of a comprehensive evaluation of patients with somatosensory disturbances or neuropathic pain in the trigeminal region.
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| 7. |
- Götherström, Anders, 1969-
(författare)
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Acquired or inherited prestige? : molecular studies of family structures and local horses in Central Svealand during the Early Medieval period
- 2001
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This is a study of the role of inheritance among the élite in Early Medieval central Svealand and the possibility to study it by molecular genetic methods. The study is a part of the research project Svealand in the Vendel and Viking periods (SIV). The study rests on classical as well as a new type of source material.Hypotheses are built on the results from a research tradition resting on more than a century of data gathering and analysis. The boat cemeteries in central Svealand hold a central position in this work. Several models have been constructed over the years to explain the appearance of these special and often rich remains. In this work they are discussed in terms of inherited or acquired status, the status that gave the individual the right to such burial. Since these sites have often been discussed in terms of control of northern trade routs, a discussion on ethnicity is inevitable. A distinction between genetic and cultural belonging is made.To test the models, built upon classic archaeological research, molecular genetics is applied to the material. A variety of such molecular systems exist for studies on modern material. Some of them have been selected and heavily modified to be applicable to archaeological material. Systems based on maternally as well as paternally and Mendelian inheritances are used. One of the goals in the methodological work has been to establish which of the methods that may reveal relevant information if applied to archaeological material.Bone material from humans as well as from horses was used to test the models. The human material was mainly gathered from excavations of boat cemeteries in central Svealand, but also from an early Christian site in southern Norrland. The horse material was from a wider geographical area, including central Svealand as well as the Baltic islands Öland and Gotland, and sites in Estonia. The material was mainly from contexts of a high social status, but also, to a much lesser extent, from more common society levels. The results reveal an archaeological potential in the genetic studies of ancient bones. Genetic relations were identified on several cemeteries (Badelunda, Alsike and Björned), but also individuals with no genetic relation to the others were identified (Alsike and Björned). Horses of different sexes and with different maternal origin were also identified.The results indicate that the kin was an important feature in the upper class during the Early Medieval period in central Svealand. The kin probably had a higher importance than gender belonging. The studied horses reveal a similar situation where features other than the sex seems to have been important. However, the family seems to have been an open unit where it was possible for outsiders to enter and become a part. Thus, inheritance was important, but it was possible for an individual with deviating background to reach a desired position in other ways. There was no absolute connection between social status and genetics. As for one of the main status object, the horse, a dynamic and continuous distribution is suggested, either based on trade or on a gift system.
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| 8. |
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| 9. |
- Sarri, Gianluca, et al.
(författare)
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Reply to a comment
- 2020
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 124
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Wijayatunga, Priyantha, 1967-, et al.
(författare)
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Discussion on the meeting on 'Data visualization'
- 2019
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Ingår i: Journal of the Royal Statistical Society. - UK : Royal Statistical Society. - 0964-1998 .- 1467-985X. ; 182:2, s. 433-441
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Visualizing both conditional and marginal associations in contingency tables by using simple diagrams is discussed
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