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Prelabor cesarean d...
Prelabor cesarean delivery and early-onset acute childhood leukemia risk.
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- Thomopoulos, Thomas P (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
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- Skalkidou, Alkistis, 1977- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
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- Dessypris, Nick (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
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- Chrousos, George (författare)
- First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, School of Medicine, University of Athens
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- Karalexi, Maria A (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
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- Karavasilis, Theodoros G (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
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- Baka, Margarita (författare)
- Department of Pediatric HematologyOncology, ‘Pan. & Agl. Kyriakou’ Children’s Hospital
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- Hatzipantelis, Emmanuel (författare)
- Second Department of Pediatrics, AHEPA General Hospital, Aristotelion University of Thessalonik
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- Kourti, Maria (författare)
- Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessalonik
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- Polychronopoulou, Sophia (författare)
- Department of Pediatric Haematology-Oncology, ‘Aghia Sophia’ Children’s Hospital
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- Sidi, Vasiliki (författare)
- Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki
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- Stiakaki, Eftichia (författare)
- Department of Pediatric HematologyOncology, University Hospital of Heraklion, Greece
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- Moschovi, Maria (författare)
- HaematologyOncology Unit, First Department of Pediatrics, Athens University Medical School, ‘Aghia Sophia’ Children’s Hospital
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- Loutradis, Dimitrios (författare)
- First Department of Obstetrics and Gynecology, ‘Alexandra’ Hospital, School of Medicine, University of Athens
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- Petridou, Eleni Th (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: European Journal of Cancer Prevention. - 0959-8278 .- 1473-5709. ; 25:2, s. 155-161
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The long-term impact of cesarean delivery (CD) on the health of the offspring is being explored methodically. We sought to investigate the effect of birth by (a) prelabor and (b) during-labor CD on the risk of early-onset (≤3 years) acute lymphoblastic leukemia (ALL), specifically of its prevailing precursor B (B-ALL) subtype. A total of 1099 incident cases of ALL (957 B-ALL), 131 of acute myeloid leukemia (AML), and their 1 : 1 age-matched and sex-matched controls, derived from the Nationwide Registry for Childhood Hematological Malignancies (1996-2013), were analyzed using multivariate regression models. A null association was found between prelabor and/or during labor CD and either ALL (B-ALL) or AML in the 0-14 age range. By contrast, birth by CD increased significantly the risk of early-onset ALL [odds ratioCD (ORCD)=1.57, 95% confidence interval (CI): 1.10-2.24] mainly on account of prelabor CD (ORprelaborCD=1.66, 95% CI: 1.13-2.43). The respective figures were even higher for the early-onset precursor B-ALL (ORCD=1.66, 95% CI: 1.15-2.40 and ORprelaborCD=1.79, 95% CI: 1.21-2.66), whereas no association emerged for early-onset AML. Prelabor CD, which deprives exposure of the fetus/infant to the presumably beneficial effect of stress hormones released in both vaginal labor and during labor CD, was associated exclusively with an increased risk of early-onset ALL, particularly the precursor B-ALL subtype. If confirmed, these adverse long-term outcomes of CD may point to re-evaluation of prelabor CD practices and prompt scientific discussion on the best ways to simulate the effects of vaginal delivery, such as a precesarean induction of labor.
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Thomopoulos, Tho ...
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Skalkidou, Alkis ...
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Dessypris, Nick
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Chrousos, George
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Karalexi, Maria ...
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Karavasilis, The ...
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visa fler...
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Baka, Margarita
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Hatzipantelis, E ...
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Kourti, Maria
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Polychronopoulou ...
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Sidi, Vasiliki
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Stiakaki, Eftich ...
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Moschovi, Maria
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Loutradis, Dimit ...
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Petridou, Eleni ...
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Uppsala universitet