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Träfflista för sökning "WFRF:(Thorlacius Henrik) srt2:(2015-2019);srt2:(2016);pers:(Wang Yongzhi)"

Sökning: WFRF:(Thorlacius Henrik) > (2015-2019) > (2016) > Wang Yongzhi

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1.
  • Changhui, Yu, et al. (författare)
  • Platelet-Derived CCL5 Regulates CXC Chemokine Formation and Neutrophil Recruitment in Acute Experimental Colitis.
  • 2016
  • Ingår i: Journal of Cellular Physiology. - : Wiley. - 1097-4652 .- 0021-9541. ; 231:2, s. 370-376
  • Tidskriftsartikel (refereegranskat)abstract
    • Accumulating data suggest that platelets not only regulate thrombosis and haemostasis but also inflammatory processes. Platelets contain numerous potent pro-inflammatory compounds, including the chemokines CCL5 and CXCL4 although their role in acute colitis remains elusive. The aim of this study was to examine the role of platelets and platelet-derived chemokines in acute colitis. Acute colitis was induced in female Balb/c mice by administration of 5% dextran sodium sulphate (DSS) for five days. Animals received a platelet-depleting, anti-CCL5, anti-CXCL4 or a control antibody prior to DSS challenge. Colonic tissue was collected for quantification of myeloperoxidase (MPO) activity, CXCL5, CXCL2, interleukin-6 (IL-6) and CCL5 levels as well as morphological analyses. Platelet depletion reduced tissue damage and clinical disease activity index in DSS-exposed animals. Platelet depletion not only reduced levels of CXCL2 and CXCL5 but also levels of CCL5 in the inflamed colon. Immunoneutralization of CCL5 but not CXCL4 reduced tissue damage, CXC chemokine expression and neutrophil recruitment in DSS-treated animals. These findings show that platelets play a key role in acute colitis by regulating CXC chemokine generation, neutrophil infiltration and tissue damage in the colon. Moreover, our results suggest that platelet-derived CCL5 is an important link between platelet activation and neutrophil recruitment in acute colitis. This article is protected by copyright. All rights reserved.
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2.
  • Wang, Yongzhi, et al. (författare)
  • Rac1 regulates bacterial toxin-induced thrombin generation.
  • 2016
  • Ingår i: Inflammation Research. - : Springer Science and Business Media LLC. - 1420-908X .- 1023-3830.
  • Tidskriftsartikel (refereegranskat)abstract
    • Systemic inflammatory response syndrome is associated with severe coagulopathy. The purpose of this study was to examine thrombin generation in systemic inflammation triggered by the endotoxin lipopolysaccharide (LPS) and the exotoxin streptococcal M1 protein.
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  • Resultat 1-2 av 2
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refereegranskat (2)
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Thorlacius, Henrik (2)
Wang, Yongzhi (2)Ta bort avgränsningen
Norström, Eva (1)
Braun, Oscar (1)
Zhang, Su (1)
Zhang, Songen (1)
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Changhui, Yu (1)
Luo, Lingtao (1)
Hwaiz, Rundk (1)
Luo, Ling Tao (1)
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Lunds universitet (2)
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Engelska (2)
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Medicin och hälsovetenskap (2)
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2016 (2)Ta bort avgränsningen

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