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A community-driven ...
A community-driven global reconstruction of human metabolism
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- Thiele, I. (author)
- Háskóli Íslands,University of Iceland
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- Swainston, N. (author)
- University of Manchester
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- Fleming, R. M. T. (author)
- Háskóli Íslands,University of Iceland
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- Hoppe, A. (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
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- Sahoo, S. (author)
- Háskóli Íslands,University of Iceland
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- Aurich, M. K. (author)
- Háskóli Íslands,University of Iceland
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- Haraldsdottir, H. (author)
- Háskóli Íslands,University of Iceland
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- Mo, M. L. (author)
- University of California
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- Rolfsson, O. (author)
- Háskóli Íslands,University of Iceland
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- Stobbe, M. D. (author)
- Netherlands Bioinformatics Centre - NBIC,Universiteit Van Amsterdam,University of Amsterdam
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- Thorleifsson, S. G. (author)
- Háskóli Íslands,University of Iceland
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- Ågren, Rasmus, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Bolling, C. (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
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- Velasco, Sergio, 1980 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Chavali, A. K. (author)
- University of Virginia
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- Dobson, P. (author)
- University of Sheffield
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- Dunn, W. B. (author)
- Christie Hospital NHS Foundation Trust,University of Manchester
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- Endler, L. (author)
- Universität Wien,University of Vienna
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- Hala, D. (author)
- University of North Texas
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- Hucka, M. (author)
- California Institute of Technology (Caltech)
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- Hull, D. (author)
- University of Manchester
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- Jameson, D. (author)
- University of Manchester
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- Jamshidi, N. (author)
- University of California
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- Jonsson, J. J. (author)
- Háskóli Íslands,University of Iceland
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- Juty, N. (author)
- European Bioinformatics Institute
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- Keating, S. (author)
- European Bioinformatics Institute
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- Nookaew, Intawat, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Le Novere, N. (author)
- European Bioinformatics Institute,Babraham Institute
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- Malys, N. (author)
- University of Manchester,The University of Warwick
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- Mazein, A. (author)
- University of Edinburgh
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- Papin, J. A. (author)
- University of Virginia
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- Price, N. D. (author)
- Institute for Systems Biology
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Selkov, E. (author)
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- Sigurdsson, M. I. (author)
- Háskóli Íslands,University of Iceland
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- Simeonidis, E. (author)
- Université du Luxembourg,University of Luxembourg,Institute for Systems Biology
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Sonnenschein, N. (author)
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- Smallbone, K. (author)
- University of Manchester
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- Sorokin, A. (author)
- Russian Academy of Sciences,University of Edinburgh
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- van Beek, Jhgm (author)
- Vrije Universiteit Amsterdam (VU)
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- Weichart, D. (author)
- University of Manchester
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- Goryanin, I. (author)
- Okinawa Institute of Science and Technology Graduate University,University of Edinburgh
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Westerhoff, H.V. (author)
- University of Manchester,Vrije Universiteit Amsterdam (VU),Swammerdam Institute for Life Sciences
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- Kell, D. B. (author)
- University of Manchester
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- Mendes, P. (author)
- University of Manchester,Virginia Polytechnic Institute and State University (Virginia Tech)
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- Palsson, B. O. (author)
- Háskóli Íslands,University of Iceland,University of California
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(creator_code:org_t)
- 2013-03-03
- 2013
- English.
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In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 31:5, s. 419-
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including similar to 2x more reactions and similar to 1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Thiele, I.
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Swainston, N.
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Fleming, R. M. T ...
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Hoppe, A.
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Sahoo, S.
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Aurich, M. K.
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show more...
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Haraldsdottir, H ...
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Mo, M. L.
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Rolfsson, O.
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Stobbe, M. D.
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Thorleifsson, S. ...
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Ågren, Rasmus, 1 ...
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Bolling, C.
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Velasco, Sergio, ...
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Chavali, A. K.
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Dobson, P.
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Dunn, W. B.
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Endler, L.
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Hala, D.
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Hucka, M.
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Hull, D.
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Jameson, D.
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Jamshidi, N.
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Jonsson, J. J.
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Juty, N.
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Keating, S.
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Nookaew, Intawat ...
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Le Novere, N.
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Malys, N.
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Mazein, A.
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Papin, J. A.
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Price, N. D.
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Selkov, E.
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Sigurdsson, M. I ...
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Simeonidis, E.
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Sonnenschein, N.
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Smallbone, K.
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Sorokin, A.
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van Beek, Jhgm
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Weichart, D.
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Goryanin, I.
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Nielsen, Jens B, ...
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Westerhoff, H.V.
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Kell, D. B.
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Mendes, P.
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Palsson, B. O.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
- Articles in the publication
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Nature Biotechno ...
- By the university
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Chalmers University of Technology