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Sökning: WFRF:(Thornton LM)

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  • [1]234567...9Nästa
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  • Cederlöf, Martin, et al. (författare)
  • Etiological overlap between obsessive-compulsive disorder and anorexia nervosa : a longitudinal cohort, multigenerational family and twin study
  • 2015
  • Ingår i: World Psychiatry. - Hoboken, USA : Wiley-Blackwell. - 1723-8617. ; 14:3, s. 333-338
  • Tidskriftsartikel (refereegranskat)abstract
    • Obsessive-compulsive disorder (OCD) often co-occurs with anorexia nervosa (AN), a comorbid profile that complicates the clinical management of both conditions. This population-based study aimed to examine patterns of comorbidity, longitudinal risks, shared familial risks and shared genetic factors between OCD and AN at the population level. Participants were individuals with a diagnosis of OCD (N=19,814) or AN (N=8,462) in the Swedish National Patient Register between January 1992 and December 2009; their first-, second- and third-degree relatives; and population-matched (1:10 ratio) unaffected comparison individuals and their relatives. Female twins from the population-based Swedish Twin Register (N=8,550) were also included. Females with OCD had a 16-fold increased risk of having a comorbid diagnosis of AN, whereas males with OCD had a 37-fold increased risk. Longitudinal analyses showed that individuals first diagnosed with OCD had an increased risk for a later diagnosis of AN (risk ratio, RR=3.6), whereas individuals first diagnosed with AN had an even greater risk for a later diagnosis of OCD (RR=9.6). These longitudinal risks were about twice as high for males than for females. First- and second-degree relatives of probands with OCD had an increased risk for AN, and the magnitude of this risk tended to increase with the degree of genetic relatedness. Bivariate twin models revealed a moderate but significant degree of genetic overlap between self-reported OCD and AN diagnoses (ra =0.52, 95% CI: 0.26-0.81), but most of the genetic variance was disorder-specific. The moderately high genetic correlation supports the idea that this frequently observed comorbid pattern is at least in part due to shared genetic factors, though disorder-specific factors are more important. These results have implications for current gene-searching efforts and for clinical practice.
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  • Hedman, Anna, et al. (författare)
  • Bidirectional relationship between eating disorders and autoimmune diseases
  • 2018
  • Ingår i: Journal of Child Psychology and Psychiatry. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 0021-9630.
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Immune system dysfunction may be associated with eating disorders, and associations could have implications for detection, risk assessment, and treatment of both autoimmune diseases and eating disorders. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between eating disorders and autoimmune diseases. Methods: In this nationwide population-based cohort study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed-up until December 2013. Cox proportional hazard regression models were used to investigate: 1) subsequent risk of eating disorders in individuals with autoimmune diseases; and 2) subsequent risk of autoimmune diseases in individuals with eating disorders. Results: We observed a strong, bidirectional relationship between the two classes of illness indicating that diagnosis in one illness class increased the risk of the other. In women, autoimmune disease diagnoses increased subsequent hazard of anorexia nervosa, bulimia nervosa, and other eating disorders. Similarly, anorexia nervosa, bulimia nervosa, and other eating disorders increased subsequent hazard of autoimmune diseases. The gastrointestinal-related autoimmune diseases celiac disease and Crohn's disease showed a bidirectional relationship with anorexia nervosa and other eating disorders. Psoriasis showed a bidirectional relationship with other eating disorders. Prior type 1 diabetes increased risk for anorexia nervosa, bulimia nervosa, and other eating disorders. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased risk for other eating disorders. Conclusions: The associations between eating disorders and autoimmune diseases provide additional support for previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses.
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  • Thornton, Laura M, et al. (författare)
  • The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.
  • 2018
  • Ingår i: Contemporary clinical trials. - 1559-2030. ; 74, s. 61-69
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research.ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H.Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable.Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.
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  • Resultat 1-10 av 88
  • [1]234567...9Nästa
 
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