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Sökning: WFRF:(Thurfjell L)

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1.
  • Thurfjell, Erik, et al. (författare)
  • Breast size and mammographic pattern in relation to breast cancer risk
  • 1996
  • Ingår i: European Journal of Cancer Prevention. - 0959-8278 .- 1473-5709. ; 5:1, s. 37-41
  • Tidskriftsartikel (refereegranskat)abstract
    • The relation of Wolfe's parenchymal patterns and radiographically-assessed breast size with breast cancer risk was evaluated in a population-based nested case-control study in Uppsala, Sweden. All women who attended a mammographic screening programme in Uppsala county starting in 1988 have been followed for the occurrence of breast cancer through 1993. The analysis was based on 295 cases and 589 age-matched controls, whose mammograms were blindly evaluated for parenchymal pattern and breast size. Women with P2 or DY pattern had a significantly elevated risk of breast cancer compared with women with N1 or P1 (OR = 2.09; 95% CI = 1.52-2.86). There was an inverse association of breast size with breast cancer risk, which disappeared after adjusting for parenchymal pattern, because breasts of smaller size tended to have high-risk parenchymal patterns. It is concluded that in Swedish women, and perhaps in Caucasian women in general, small breast size is associated with increasing breast risk through its association with high-risk parenchymal pattern. This is in contrast to the fact that Asian women, who in general have breasts of smaller size, have low prevalence of high-risk parenchymal pattern as well as low rates of breast cancer.
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2.
  • Thurfjell, L., et al. (författare)
  • Automatic Detection of Hypoperfused Areas in SPECT Brain Scans
  • 1998
  • Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 45:4, s. 2149-2154
  • Tidskriftsartikel (refereegranskat)abstract
    • Describes a method for automatic identification of areas with perfusion changes in SPECT brain images. An intersubject registration technique is used to stereotactically register images from a selected control group allowing for reference images to be created by averaging the subjects image data. An individual SPECT brain scan can be brought into registration with the reference image and comparison to the normal reference group can be made by subtracting the two volumes. Furthermore, since the variance in the reference group is known, a z-score image or an image coded in standard deviations, can be computed. The SPECT reference volume is defined in the same coordinate system as a brain atlas, and anatomical labeling of areas of interest is possible. The authors show results from the creation of an average image based on 11 individuals and from its comparison with pathological cases
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3.
  • Antila, Kari, et al. (författare)
  • The PredictAD project : development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease
  • 2013
  • Ingår i: Interface Focus. - : The Royal Society Publishing. - 2042-8898 .- 2042-8901. ; 3:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Alzheimer's disease (AD) is the most common cause of dementia affecting 36 million people worldwide. As the demographic transition in the developed countries progresses towards older population, the worsening ratio of workers per retirees and the growing number of patients with age-related illnesses such as AD will challenge the current healthcare systems and national economies. For these reasons AD has been identified as a health priority, and various methods for diagnosis and many candidates for therapies are under intense research. Even though there is currently no cure for AD, its effects can be managed. Today the significance of early and precise diagnosis of AD is emphasized in order to minimize its irreversible effects on the nervous system. When new drugs and therapies enter the market it is also vital to effectively identify the right candidates to benefit from these. The main objective of the PredictAD project was to find and integrate efficient biomarkers from heterogeneous patient data to make early diagnosis and to monitor the progress of AD in a more efficient, reliable and objective manner. The project focused on discovering biomarkers from biomolecular data, electrophysiological measurements of the brain and structural, functional and molecular brain images. We also designed and built a statistical model and a framework for exploiting these biomarkers with other available patient history and background data. We were able to discover several potential novel biomarker candidates and implement the framework in software. The results are currently used in several research projects, licensed to commercial use and being tested for clinical use in several trials.
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4.
  • Barnden, L, et al. (författare)
  • Validation of fully automatic brain SPET to MR co-registration
  • 2000
  • Ingår i: EUROPEAN JOURNAL OF NUCLEAR MEDICINE. - 0340-6997. ; 27:2, s. 147-154
  • Tidskriftsartikel (refereegranskat)abstract
    • Fully automatic co-registration of functional to anatomical brain images using information intrinsic to the scans has been validated in a clinical setting for positron emission tomography (PET), but not for single-photon emission tomography (SPET). In thi
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  • Resultat 1-10 av 40
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