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- Pagani, M, et al.
(författare)
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Mapping pathological (99m)Tc-d,l-hexamethylpropylene amine oxime uptake in Alzheimer's disease and frontal lobe dementia with SPECT
- 2001
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Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 12:3, s. 177-184
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Tidskriftsartikel (refereegranskat)abstract
- Seventeen patients with probable Alzheimer’s disease (AD), 7 patients with frontal lobe dementia (FLD) and 19 control subjects (NOR) were examined by <sup>99m</sup>Tc-<i>d,l</i>- hexamethylpropylene amine oxime (<sup>99m</sup>Tc-HMPAO) SPECT. Images were standardised in the same 3D space and averaged within each group. After normalisation, the three sets of images were analysed in all cerebral lobes, hippocampus, thalamus and basal ganglia. In AD, the <sup>99m</sup>Tc-HMPAO uptake values were significantly reduced, as compared to NOR, in the parietal, temporal and insular lobes. In patients with FLD, the uptake was altered in all lobes with the exception of the parietal lobe. The uptake in the nucleus caudatus decreased significantly in both AD and FLD as compared to NOR. The uptake in the anterior cingulate cortex was significantly reduced in FLD. Subtraction images highlighted all significantly decreased areas. In conclusion, standardising SPECT in a common space and subtracting data from a control group improves the visual interpretation of images. In this study, the typical temporo-parietal and fronto-parietal <sup>99m</sup>Tc-HMPAO uptake reductions were found in AD and FLD, respectively. The uptake in the nucleus caudatus was found to decrease significantly in AD and FLD and the one in the anterior cingulate cortex was reduced in FLD.
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| 2. |
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| 3. |
- Thurfjell, L., et al.
(författare)
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Automatic Detection of Hypoperfused Areas in SPECT Brain Scans
- 1998
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Ingår i: IEEE Transactions on Nuclear Science. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9499 .- 1558-1578. ; 45:4, s. 2149-2154
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Tidskriftsartikel (refereegranskat)abstract
- Describes a method for automatic identification of areas with perfusion changes in SPECT brain images. An intersubject registration technique is used to stereotactically register images from a selected control group allowing for reference images to be created by averaging the subjects image data. An individual SPECT brain scan can be brought into registration with the reference image and comparison to the normal reference group can be made by subtracting the two volumes. Furthermore, since the variance in the reference group is known, a z-score image or an image coded in standard deviations, can be computed. The SPECT reference volume is defined in the same coordinate system as a brain atlas, and anatomical labeling of areas of interest is possible. The authors show results from the creation of an average image based on 11 individuals and from its comparison with pathological cases
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| 4. |
- Thurfjell, L, et al.
(författare)
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Registration of neuroimaging data: Implementation and clinical applications
- 2000
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Ingår i: JOURNAL OF NEUROIMAGING. - 1051-2284. ; 10:1, s. 39-46
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Tidskriftsartikel (refereegranskat)abstract
- Image registration brings images into a form in which each voxel corresponds to a predetermined anatomic entity and is necessary for comparisons of data across scans. Intrasubject registration is a matter of translating and rotating one image volume into
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