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Sökning: WFRF:(Tingting Q)

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1.
  • Ho, Joshua W. K., et al. (författare)
  • Comparative analysis of metazoan chromatin organization
  • 2014
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 512:7515, s. 449-U507
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin components and mechanisms(1-3). Nevertheless, the three organisms have markedly different genome sizes, chromosome architecture and gene organization. On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, whereas worm chromosomes have dispersed heterochromatin-like regions enriched in the distal chromosomal 'arms', and centromeres distributed along their lengths(4,5). To systematically investigate chromatin organization and associated gene regulation across species, we generated and analysed a large collection of genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human. Here we present over 800 new data sets from our ENCODE and modENCODE consortia, bringing the total to over 1,400. Comparison of combinatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large-scale topological domains, chromatin environment at promoters and enhancers, nucleosome positioning, and DNA replication patterns reveals many conserved features of chromatin organization among the three organisms. We also find notable differences in the composition and locations of repressive chromatin. These data sets and analyses provide a rich resource for comparative and species-specific investigations of chromatin composition, organization and function.
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2.
  • Wang, Q., et al. (författare)
  • Characterizing the traffic load distribution in dense wireless sensor networks
  • 2011
  • Ingår i: Journal of Networks. - : Academy Publisher. - 1796-2056. ; 6:2, s. 173-180
  • Tidskriftsartikel (refereegranskat)abstract
    • Traffic load is typically not evenly distributed over the sensor nodes in a wireless sensor network (WSN). Understanding the traffic load distribution can guide the network-wide energy allocation, the design of routing algorithms, and the optimization of the node deployment in WSNs. This article considers a dense WSN with nodes uniformly distributed in a disk sensing area, where the expected traffic load distribution over the sensor nodes as a function of their distance from the sink has been derived. Further, the effects of the network scale and routing strategy on traffic load distribution are also investigated. The expected traffic loads beared by individual sensor nodes are found to be in direct proportion to the radius of the network and inversively proportional to the routing hop length but it is independent of the network density. In addition, a heuristic multipath routing algorithm is found to be capable of reducing the traffic load variance experienced by neighboring or symmetrically deployed sensor nodes. The results presented in this article are verified through extensive simulation experiments. © 2011 ACADEMY PUBLISHER.
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