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- Fischer, Hans, et al.
(författare)
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Altered microbiota in microscopic colitis
- 2015
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Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 64:7, s. 1185-1186
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Grape, T, et al.
(författare)
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Primary gastroduodenal amyloidosis
- 2011
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Ingår i: Endoscopy. - : Georg Thieme Verlag KG. - 1438-8812 .- 0013-726X. ; 43, s. 288-288
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Thorlacius, Henrik, et al.
(författare)
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Sågtandande polyper en dold men vanlig orsak till kolorektal cancer : Serrated polyps is a hidden but common cause of colorectal cancer
- 2015
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Ingår i: Läkartidningen. - 0023-7205. ; 112:34-35, s. 1401-1405
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Konceptet att sågtandande polyper kan leda till kolorektal cancer är relativt nytt. Sågtandade polyper orsakar upp till en tredjedel av all sporadisk kolorektal cancer. Trots detta är kunskaperna om sågtandade polypers etiologi, incidens, prevalens och naturalförlopp ofullständiga. Sågtandade polyper är svåra att identifiera och ta bort endoskopiskt. Endoskopister och patologer måste ha kunskaper om sågtandade adenom för att effektivt kunna detektera, diagnostisera och ta bort dem som led i att minska antalet personer som drabbas av kolorektal cancer. The concept that serrated polyps can cause colorectal cancer is relatively new and not very well-known. Serrated polyps are difficult to identify and treat endoscopically. This together with the fact that premalignant serrated polyps are mainly located in the proximal colon might help explain why colonoscopy is less effective against right-sided compared to left-sided colorectal cancers and why interval cancers usually appear in the proximal colon. In fact, serrated polyps may cause up to one third of all sporadic colorectal cancers. In spite of this, the aetiology, incidence, prevalence and natural history of serrated polyps remains elusive. Endoscopists and pathologists must have a good understanding of serrated polyps in order to effectively diagnose, treat and follow up these lesions. This review focuses on the pathophysiology, types, work-up, treatment and follow-up of serrated polyps in the colon and rectum.
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| 10. |
- Toth, Ervin
(författare)
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Chromoendoscopy with particular reference to a modified endoscopic Congo red test
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Chromoendoscopy, endoscopic tissue staining, is an adjunctive method using chemical agents applied to the mucosal surface in order to aid gastrointestinal endoscopic diagnosis and therapy. Acid producing mucosa in the GI tract may be visualized endoscopically by Congo red staining in combination with stimulation of gastric acid production. Congo red is a reactive indicator dye that changes color from red to dark blue/black at a pH of less than three. We have modified the conventional Congo red test, and characterized a rapid approach, modified endoscopic Congo red test (MCRT). In this test, within five minutes after pentagastrin injection, the Congo red coated normal, acid producing fundal mucosa turns to a blue/black color. The two shortcomings in the original method, the time of dose-response and the dose of acid stimulant pentagastrin, are circumvented by our modification. The dose-response delay was reduced by 63% from 10-20 minutes to around five minutes, and the dose/kg of pentagastrin by 30 times, giving it intravenously instead of intra-muscularly. MCRT was applied in 589 examinations in order to study gastric mucosa in subjects with both non-operated and resected stomachs. MCRT was found to be a rapid, inexpensive and well-tolerated method to visualize acid producing mucosa during routine gastroscopic examination. MCRT increases the diagnostic accuracy of routine gastroscopy in detecting chronic atrophic fundal gastritis (sensitivity from 0.25 to 1.0 and specificity from 0.88 to 0.95, respectively). This is a rapid and accurate method (accuracy 0.98) to detect hypo/achlorhydria during gastroscopic examination. Morphological and functional information provided by MCRT may influence the clinical managements of patients. Future outcome studies should more precisely define the potential indications and the clinical benefit of MCRT.
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