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Seventy-five genetic loci influencing the human red blood cell

van der Harst, Pim (author)
Zhang, Weihua (author)
Leach, Irene Mateo (author)
show more...
Rendon, Augusto (author)
Verweij, Niek (author)
Sehmi, Joban (author)
Paul, Dirk S. (author)
Elling, Ulrich (author)
Allayee, Hooman (author)
Li, Xinzhong (author)
Radhakrishnan, Aparna (author)
Tan, Sian-Tsung (author)
Voss, Katrin (author)
Weichenberger, Christian X. (author)
Albers, Cornelis A. (author)
Al-Hussani, Abtehale (author)
Asselbergs, Folkert W. (author)
Ciullo, Marina (author)
Danjou, Fabrice (author)
Dina, Christian (author)
Esko, Tonu (author)
Evans, David M. (author)
Franke, Lude (author)
Goegele, Martin (author)
Hartiala, Jaana (author)
Hersch, Micha (author)
Holm, Hilma (author)
Hottenga, Jouke-Jan (author)
Kanoni, Stavroula (author)
Kleber, Marcus E. (author)
Lagou, Vasiliki (author)
Langenberg, Claudia (author)
Lopez, Lorna M. (author)
Lyytikainen, Leo-Pekka (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Murgia, Federico (author)
Nolte, Ilja M. (author)
O'Reilly, Paul F. (author)
Padmanabhan, Sandosh (author)
Parsa, Afshin (author)
Pirastu, Nicola (author)
Porcu, Eleonora (author)
Portas, Laura (author)
Prokopenko, Inga (author)
Ried, Janina S. (author)
Shin, So-Youn (author)
Tang, Clara S. (author)
Teumer, Alexander (author)
Traglia, Michela (author)
Ulivi, Sheila (author)
Westra, Harm-Jan (author)
Yang, Jian (author)
Zhao, Jing Hua (author)
Anni, Franco (author)
Abdellaoui, Abdel (author)
Attwood, Antony (author)
Balkau, Beverley (author)
Bandinelli, Stefania (author)
Bastardot, Francois (author)
Benyamin, Beben (author)
Boehm, Bernhard O. (author)
Cookson, William O. (author)
Das, Debashish (author)
de Bakker, Paul I. W. (author)
de Boer, Rudolf A. (author)
de Geus, Eco J. C. (author)
de Moor, Marleen H. (author)
Dimitriou, Maria (author)
Domingues, Francisco S. (author)
Doering, Angela (author)
Engström, Gunnar (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
Eyjolfsson, Gudmundur Ingi (author)
Ferrucci, Luigi (author)
Fischer, Krista (author)
Galanello, Renzo (author)
Garner, Stephen F. (author)
Genser, Bernd (author)
Gibson, Quince D. (author)
Girotto, Giorgia (author)
Gudbjartsson, Daniel Fannar (author)
Harris, Sarah E. (author)
Hartikainen, Anna-Liisa (author)
Hastie, Claire E. (author)
Hedblad, Bo (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
Illig, Thomas (author)
Jolley, Jennifer (author)
Kahonen, Mika (author)
Kema, Ido P. (author)
Kemp, John P. (author)
Liang, Liming (author)
Lloyd-Jones, Heather (author)
Loos, Ruth J. F. (author)
Meacham, Stuart (author)
Medland, Sarah E. (author)
Meisinger, Christa (author)
Memari, Yasin (author)
Mihailov, Evelin (author)
Miller, Kathy (author)
Moffatt, Miriam F. (author)
Nauck, Matthias (author)
Novatchkova, Maria (author)
Nutile, Teresa (author)
Olafsson, Isleifur (author)
Onundarson, Pall T. (author)
Parracciani, Debora (author)
Penninx, Brenda W. (author)
Perseu, Lucia (author)
Piga, Antonio (author)
Pistis, Giorgio (author)
Pouta, Anneli (author)
Puc, Ursula (author)
Raitakari, Olli (author)
Ring, Susan M. (author)
Robino, Antonietta (author)
Ruggiero, Daniela (author)
Ruokonen, Aimo (author)
Saint-Pierre, Aude (author)
Sala, Cinzia (author)
Salumets, Andres (author)
Sambrook, Jennifer (author)
Schepers, Hein (author)
Schmidt, Carsten Oliver (author)
Sillje, Herman H. W. (author)
Sladek, Rob (author)
Smit, Johannes H. (author)
Starr, John M. (author)
Stephens, Jonathan (author)
Sulem, Patrick (author)
Tanaka, Toshiko (author)
Thorsteinsdottir, Unnur (author)
Tragante, Vinicius (author)
van Gilst, Wiek H. (author)
van Pelt, L. Joost (author)
van Veldhuisen, Dirk J. (author)
Voelker, Uwe (author)
Whitfield, John B. (author)
Willemsen, Gonneke (author)
Winkelmann, Bernhard R. (author)
Wirnsberger, Gerald (author)
Algra, Ale (author)
Cucca, Francesco (author)
d'Adamo, Adamo Pio (author)
Danesh, John (author)
Deary, Ian J. (author)
Dominiczak, Anna F. (author)
Elliott, Paul (author)
Fortina, Paolo (author)
Froguel, Philippe (author)
Gasparini, Paolo (author)
Greinacher, Andreas (author)
Hazen, Stanley L. (author)
Jarvelin, Marjo-Riitta (author)
Khaw, Kay Tee (author)
Lehtimaki, Terho (author)
Maerz, Winfried (author)
Martin, Nicholas G. (author)
Metspalu, Andres (author)
Mitchell, Braxton D. (author)
Montgomery, Grant W. (author)
Moore, Carmel (author)
Navis, Gerjan (author)
Pirastu, Mario (author)
Pramstaller, Peter P. (author)
Ramirez-Solis, Ramiro (author)
Schadt, Eric (author)
Scott, James (author)
Shuldiner, Alan R. (author)
Smith, George Davey (author)
Smith, Gustav (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Snieder, Harold (author)
Sorice, Rossella (author)
Spector, Tim D. (author)
Stefansson, Kari (author)
Stumvoll, Michael (author)
Tang, W. H. Wilson (author)
Toniolo, Daniela (author)
Toenjes, Anke (author)
Visscher, Peter M. (author)
Vollenweider, Peter (author)
Wareham, Nicholas J. (author)
Wolffenbuttel, Bruce H. R. (author)
Boomsma, Dorret I. (author)
Beckmann, Jacques S. (author)
Dedoussis, George V. (author)
Deloukas, Panos (author)
Ferreira, Manuel A. (author)
Sanna, Serena (author)
Uda, Manuela (author)
Hicks, Andrew A. (author)
Penninger, Josef Martin (author)
Gieger, Christian (author)
Kooner, Jaspal S. (author)
Ouwehand, Willem H. (author)
Soranzo, Nicole (author)
Chambers, John C. (author)
show less...
 (creator_code:org_t)
2012-12-05
2012
English.
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 492:7429, s. 369-375
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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van der Harst, P ...
Zhang, Weihua
Leach, Irene Mat ...
Rendon, Augusto
Verweij, Niek
Sehmi, Joban
show more...
Paul, Dirk S.
Elling, Ulrich
Allayee, Hooman
Li, Xinzhong
Radhakrishnan, A ...
Tan, Sian-Tsung
Voss, Katrin
Weichenberger, C ...
Albers, Cornelis ...
Al-Hussani, Abte ...
Asselbergs, Folk ...
Ciullo, Marina
Danjou, Fabrice
Dina, Christian
Esko, Tonu
Evans, David M.
Franke, Lude
Goegele, Martin
Hartiala, Jaana
Hersch, Micha
Holm, Hilma
Hottenga, Jouke- ...
Kanoni, Stavroul ...
Kleber, Marcus E ...
Lagou, Vasiliki
Langenberg, Clau ...
Lopez, Lorna M.
Lyytikainen, Leo ...
Melander, Olle
Murgia, Federico
Nolte, Ilja M.
O'Reilly, Paul F ...
Padmanabhan, San ...
Parsa, Afshin
Pirastu, Nicola
Porcu, Eleonora
Portas, Laura
Prokopenko, Inga
Ried, Janina S.
Shin, So-Youn
Tang, Clara S.
Teumer, Alexande ...
Traglia, Michela
Ulivi, Sheila
Westra, Harm-Jan
Yang, Jian
Zhao, Jing Hua
Anni, Franco
Abdellaoui, Abde ...
Attwood, Antony
Balkau, Beverley
Bandinelli, Stef ...
Bastardot, Franc ...
Benyamin, Beben
Boehm, Bernhard ...
Cookson, William ...
Das, Debashish
de Bakker, Paul ...
de Boer, Rudolf ...
de Geus, Eco J. ...
de Moor, Marleen ...
Dimitriou, Maria
Domingues, Franc ...
Doering, Angela
Engström, Gunnar
Eyjolfsson, Gudm ...
Ferrucci, Luigi
Fischer, Krista
Galanello, Renzo
Garner, Stephen ...
Genser, Bernd
Gibson, Quince D ...
Girotto, Giorgia
Gudbjartsson, Da ...
Harris, Sarah E.
Hartikainen, Ann ...
Hastie, Claire E ...
Hedblad, Bo
Illig, Thomas
Jolley, Jennifer
Kahonen, Mika
Kema, Ido P.
Kemp, John P.
Liang, Liming
Lloyd-Jones, Hea ...
Loos, Ruth J. F.
Meacham, Stuart
Medland, Sarah E ...
Meisinger, Chris ...
Memari, Yasin
Mihailov, Evelin
Miller, Kathy
Moffatt, Miriam ...
Nauck, Matthias
Novatchkova, Mar ...
Nutile, Teresa
Olafsson, Isleif ...
Onundarson, Pall ...
Parracciani, Deb ...
Penninx, Brenda ...
Perseu, Lucia
Piga, Antonio
Pistis, Giorgio
Pouta, Anneli
Puc, Ursula
Raitakari, Olli
Ring, Susan M.
Robino, Antoniet ...
Ruggiero, Daniel ...
Ruokonen, Aimo
Saint-Pierre, Au ...
Sala, Cinzia
Salumets, Andres
Sambrook, Jennif ...
Schepers, Hein
Schmidt, Carsten ...
Sillje, Herman H ...
Sladek, Rob
Smit, Johannes H ...
Starr, John M.
Stephens, Jonath ...
Sulem, Patrick
Tanaka, Toshiko
Thorsteinsdottir ...
Tragante, Vinici ...
van Gilst, Wiek ...
van Pelt, L. Joo ...
van Veldhuisen, ...
Voelker, Uwe
Whitfield, John ...
Willemsen, Gonne ...
Winkelmann, Bern ...
Wirnsberger, Ger ...
Algra, Ale
Cucca, Francesco
d'Adamo, Adamo P ...
Danesh, John
Deary, Ian J.
Dominiczak, Anna ...
Elliott, Paul
Fortina, Paolo
Froguel, Philipp ...
Gasparini, Paolo
Greinacher, Andr ...
Hazen, Stanley L ...
Jarvelin, Marjo- ...
Khaw, Kay Tee
Lehtimaki, Terho
Maerz, Winfried
Martin, Nicholas ...
Metspalu, Andres
Mitchell, Braxto ...
Montgomery, Gran ...
Moore, Carmel
Navis, Gerjan
Pirastu, Mario
Pramstaller, Pet ...
Ramirez-Solis, R ...
Schadt, Eric
Scott, James
Shuldiner, Alan ...
Smith, George Da ...
Smith, Gustav
Snieder, Harold
Sorice, Rossella
Spector, Tim D.
Stefansson, Kari
Stumvoll, Michae ...
Tang, W. H. Wils ...
Toniolo, Daniela
Toenjes, Anke
Visscher, Peter ...
Vollenweider, Pe ...
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Wolffenbuttel, B ...
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Beckmann, Jacque ...
Dedoussis, Georg ...
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Ferreira, Manuel ...
Sanna, Serena
Uda, Manuela
Hicks, Andrew A.
Penninger, Josef ...
Gieger, Christia ...
Kooner, Jaspal S ...
Ouwehand, Willem ...
Soranzo, Nicole
Chambers, John C ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
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Nature
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Lund University

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