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1.	Langefeld, Carl D., et al. (författare) Transancestral mapping and genetic load in systemic lupus erythematosus 2017 Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8 Tidskriftsartikel (refereegranskat)abstract Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.
2.	Seldin, M. F., et al. (författare) Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus 2008 Ingår i: Genes and Immunity. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 9:4, s. 389-393 Tidskriftsartikel (refereegranskat)abstract Previous studies have demonstrated that in admixed populations, West African ancestry is associated with an increased prevalence of systemic lupus erythematosus (SLE). In the current study, the effect of Amerindian ancestry in SLE was examined in an admixed population in Argentina. The Argentine population is predominantly European with approximately 20% Amerindian admixture, and a very small (<2%) contribution from West Africa. The results indicate that Amerindian admixture in this population is associated with a substantial increase in SLE susceptibility risk (Odds Ratio=7.94, P=0.00006). This difference was not due to known demographic factors, including site of collection, age and gender. In addition, there were trends towards significance for Amerindian ancestry influencing renal disease, age of onset and anti-SSA antibodies. These studies suggest that populations with Amerindian admixture, like those with West African admixture, should be considered in future studies to identify additional allelic variants that predispose to SLE.
3.	Johansson, Cecilia, et al. (författare) Association analysis with microsatellite and SNP markers does not support the involvement of Bcl-2 in systemic lupus erythematosus in Mexican and Swedish patients and their families 2000 Ingår i: Genes Immun.. - : Springer Science and Business Media LLC. ; 1:6, s. 380-385 Tidskriftsartikel (refereegranskat)
4.	Prokunina, Ludmila, et al. (författare) The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis 2004 Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 50:1, s. 327-8 Tidskriftsartikel (refereegranskat)

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Resultat 1-4 av 4

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Typ av publikation: tidskriftsartikel (4)

Typ av innehåll: refereegranskat (4)

Författare/redaktör: Alarcón-Riquelme... (4)Ta bort avgränsningen; Truedsson, Lennart (3); Gunnarsson, Iva (2); Criswell, Lindsey A. (2); et al., (1); Abderrahim, H (1); visa fler...; Svenungsson, Elisabe ... (1); Scherbarth, Hugo R (1); Berbotto, Guillermo ... (1); García, Mercedes A (1); Sturfelt, Gunnar (1); D'Alfonso, Sandra (1); Baca, Vicente (1); Orozco, Lorena (1); Ortego-Centeno, Norb ... (1); Pons-Estel, Bernardo ... (1); Martin, Javier (1); Johansson, Cecilia (1); Carlsson Almlöf, Jon ... (1); Rönnblom, Lars (1); Kelly, Jennifer A. (1); Kaufman, Kenneth M. (1); Guthridge, Joel M. (1); Brown, Elizabeth E. (1); Ramsey-Goldman, Rosa ... (1); Reveille, John D. (1); Vila, Luis M. (1); Edberg, Jeffrey C. (1); Freedman, Barry I. (1); Gregersen, Peter K. (1); Gilkeson, Gary S. (1); Jacob, Chaim O. (1); James, Judith A. (1); Kamen, Diane L. (1); Kimberly, Robert P. (1); Merrill, Joan T. (1); Niewold, Timothy B. (1); Tsao, Betty P. (1); Vyse, Timothy J. (1); Langefeld, Carl D. (1); Harley, John B. (1); Gaffney, Patrick M. (1); Lundberg, I (1); Frostegard, Johan (1); Cervera, Ricard (1); Gunnarsson, I (1); Sjöwall, Christopher (1); Frostegård, Johan (1); Prokunina, Ludmila (1); Johanneson, B (1); visa färre...

Lärosäte: Uppsala universitet (4); Lunds universitet (3); Karolinska Institutet (3); Umeå universitet (1); Linköpings universitet (1)

Språk: Engelska (4)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3)

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