| 1. |
- Eriksson, Lennart, et al.
(author)
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Editorial
- 2007
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In: Journal of Chemometrics. - : John Wiley & Sons, Ltd. - 0886-9383 .- 1099-128X. ; 21:10-11, s. 397-
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Journal article (pop. science, debate, etc.)abstract
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| 2. |
- Lundstedt, Torbjörn, et al.
(author)
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Editorial
- 2006
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In: Journal of Chemometrics. - : John Wiley & Sons, Ltd. - 0886-9383 .- 1099-128X. ; 20:8-10, s. 323-324
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Journal article (pop. science, debate, etc.)
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| 3. |
- Aspeborg, Henrik, 1970-, et al.
(author)
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Vegetabile material, plants and a method of producing a plant having altered lignin properties
- 2008
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Patent (pop. science, debate, etc.)abstract
- The present invention is related to a set of genes, which when modified in plants gives altered lignin properties. The invention provides DNA construct such as a vector useful in the method of the invention. Further, the invention relates to a plant cell or plant progeny of the plants and wood produced by the plants according to the invention Lower lignin levels will result in improved saccharification for bio-refining and ethanol production and improved pulp and paper. Increased lignin levels will utilise lignin properties for energy production. The genes and DNA constructs may be used for the identification of plants having altered lignin characteristics as compared to the wild-type. According to the invention genes and DNA constructs may also be used as candidate genes in marker assisted breeding.
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| 4. |
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| 5. |
- Jonsson, Pär, et al.
(author)
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Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets
- 2005
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In: The Analyst. - : Royal Society of Chemistry (RSC). - 0003-2654 .- 1364-5528. ; 130:5, s. 701-707
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Journal article (pop. science, debate, etc.)abstract
- LC/MS is an analytical technique that, due to its high sensitivity, has become increasingly popular for the generation of metabolic signatures in biological samples and for the building of metabolic data bases. However, to be able to create robust and interpretable ( transparent) multivariate models for the comparison of many samples, the data must fulfil certain specific criteria: (i) that each sample is characterized by the same number of variables, (ii) that each of these variables is represented across all observations, and (iii) that a variable in one sample has the same biological meaning or represents the same metabolite in all other samples. In addition, the obtained models must have the ability to make predictions of, e. g. related and independent samples characterized accordingly to the model samples. This method involves the construction of a representative data set, including automatic peak detection, alignment, setting of retention time windows, summing in the chromatographic dimension and data compression by means of alternating regression, where the relevant metabolic variation is retained for further modelling using multivariate analysis. This approach has the advantage of allowing the comparison of large numbers of samples based on their LC/MS metabolic profiles, but also of creating a means for the interpretation of the investigated biological system. This includes finding relevant systematic patterns among samples, identifying influential variables, verifying the findings in the raw data, and finally using the models for predictions. The presented strategy was here applied to a population study using urine samples from two cohorts, Shanxi (People's Republic of China) and Honolulu ( USA). The results showed that the evaluation of the extracted information data using partial least square discriminant analysis (PLS-DA) provided a robust, predictive and transparent model for the metabolic differences between the two populations. The presented findings suggest that this is a general approach for data handling, analysis, and evaluation of large metabolic LC/MS data sets.
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| 6. |
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| 7. |
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| 8. |
- Lundstedt, Erik Torbjörn, et al.
(author)
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Metabolic profiles
- 2012
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Patent (pop. science, debate, etc.)abstract
- The invention relates to the use of endogenous metabolites to produce a metabolic profile of a disorder or disease in a subject, e.g. an autoimmune disease, in particular rheumatoid arthritis, and the analysis of such metabolic profiles in order to find disturbances in such profiles in a subject which are caused by or correlated with the said diseases or disorders. Such disturbances can be normalised by treatment of the subject with specified compounds, particularly N-(2-chloro-3,4-dimethoxybenzylideneamino)guanidine or an aminoguanidine.
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| 9. |
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| 10. |
- Street, Nathaniel Robert, 1979-, et al.
(author)
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A cross-species transcriptomics approach to identify genes involved in leaf development
- 2008
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In: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 9:1, s. 539-
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Journal article (pop. science, debate, etc.)abstract
- BackgroundWe have made use of publicly available gene expression data to identify transcription factors and transcriptional modules (regulons) associated with leaf development in Populus. Different tissue types were compared to identify genes informative in the discrimination of leaf and non-leaf tissues. Transcriptional modules within this set of genes were identified in a much wider set of microarray data collected from leaves in a number of developmental, biotic, abiotic and transgenic experiments.ResultsTranscription factors that were over represented in leaf EST libraries and that were useful for discriminating leaves from other tissues were identified, revealing that the C2C2-YABBY, CCAAT-HAP3 and 5, MYB, and ZF-HD families are particularly important in leaves. The expression of transcriptional modules and transcription factors was examined across a number of experiments to select those that were particularly active during the early stages of leaf development. Two transcription factors were found to collocate to previously published Quantitative Trait Loci (QTL) for leaf length. We also found that miRNA family 396 may be important in the control of leaf development, with three members of the family collocating with clusters of leaf development QTL.ConclusionThis work provides a set of candidate genes involved in the control and processes of leaf development. This resource can be used for a wide variety of purposes such as informing the selection of candidate genes for association mapping or for the selection of targets for reverse genetics studies to further understanding of the genetic control of leaf size and shape.
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