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Sökning: WFRF:(Tuisku J)

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  • Woodard, J., et al. (författare)
  • Zircon and monazite geochronology of deformation in the Pielavesi Shear Zone, Finland: multistage evolution of the Archaean–Proterozoic boundary in the Fenoscandian Shield.
  • 2017
  • Ingår i: Journal of the Geological Society. - : GEOLOGICAL SOC PUBL HOUSE. - 0016-7649 .- 2041-479X. ; 174, s. 255-267
  • Tidskriftsartikel (refereegranskat)abstract
    • The Raahe–Ladoga Shear Complex is a major crustal structure representing the Archaean–Palaeoproterozoic boundary in the Fennoscandian Shield. The complex developed during the Svecofennian Orogeny (c. 1.9 – 1.8 Ga) beginning with regional thrust tectonic phases D1 and D2, followed by large-scale shearing events D3 and D4. The Pielavesi Shear Zone is a vertical north–south-trending shear zone within the Raahe–Ladoga Shear Complex formed during regional D3 shearing and later reactivated during the regional D4 phase. Three north–south-trending elongate granitoid intrusions were selected as representative of silicic melts that intruded the transtensional Pielavesi Shear Zone during the regional D3 phase. The oriented magmatic fabric of the granitoids indicates that they intruded coeval to the deformation event. The zircon U–(Th)–Pb secondary ionization mass spectrometry (SIMS) ages of these intrusions (1888 ± 4, 1884 ± 6 and 1883 ± 5 Ma) overlap within error and provide a direct age for the regional D3 deformation. εHf(T)(−1.1 to +3.4) and εNd(T) (−1.2 to +0.4) values from these granitoids are both consistent with a predominantly juvenile source affected by a minor Archaean component. U–(Th)–Pb SIMS analyses of metamorphic monazite formed within a crosscutting blastomylonite provide an age for the regional D4phase and associated fluid activity of 1793 ± 3 Ma.
  • Eerola, Paula, et al. (författare)
  • The Nordugrid production grid infrastructure, status and plans
  • 2003
  • Ingår i: Proceedings. Fourth International Workshop on Grid Computing. - : IEEE - Institute of Electrical and Electronics Engineers Inc.. - 076952026X ; , s. 158-165
  • Konferensbidrag (refereegranskat)abstract
    • Nordugrid offers reliable grid services for academic users over an increasing set of computing & storage resources spanning through the Nordic countries Denmark, Finland, Norway and Sweden. A small group of scientists has already been using the Nordugrid as their daily computing utility. In the near future we expect a rapid growth both in the number of active users and available resources thanks to the recently launched Nordic grid projects.We report on the present status and short term plans of the Nordic grid infrastructure and describe the available and foreseen resources, grid services and our forming user base
  • Toppala, Sini, et al. (författare)
  • Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia
  • 2021
  • Ingår i: Neurology. - : Wolters Kluwer. - 0028-3878 .- 1526-632X. ; 96:12, s. e1608-e1619
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To examine whether early β-amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia.METHODS: We examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4 carriers) with the translocator protein (TSPO) tracer [11C]PBR28 to assess neuroinflammation and with [11C] Pittsburgh compound B (PiB) to assess cerebral Aβ accumulation. [11C]PBR28 and [11C]PiB standardized uptake value ratios (SUVRs) were quantified in 6 regions of interests by using the cerebellar cortex as a pseudo-reference and reference region, respectively. Fasting venous glucose, insulin, and high-sensitivity C-reactive protein (hs-CRP) values were determined. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. A subset of individuals (n = 11) underwent CSF sampling, and Aβ40, Aβ42, total tau, phospho-tau, soluble TREM2, and YKL-40 levels were measured.RESULTS: Among the whole study group, no significant association was found between [11C]PiB and [11C]PBR28 SUVR composite scores (slope 0.02, p = 0.30). However, higher [11C]PiB binding was associated with higher [11C]PBR28 binding among amyloid-negative ([11C]PiB composite score ≤1.5) (TSPO genotype-, age- and sex-adjusted slope 0.26, p = 0.008) but not among amyloid-positive (slope -0.004, p = 0.88) participants. Higher CSF soluble TREM2 (rs = 0.72, p = 0.01) and YKL-40 (rs = 0.63, p = 0.04) concentrations were associated with a higher [11C]PBR28 composite score. Higher body mass index, HOMA-IR, and hs-CRP were associated with higher [11C]PBR28 binding in brain regions where Aβ accumulation is first detected in Alzheimer disease.CONCLUSIONS: While there was no association between amyloid and neuroinflammation in the overall study group, neuroinflammation was associated with amyloid among the subgroup at early stages of amyloid pathology.
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