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1.	Skarpengland, T, et al. (author) Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice 2016 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6, s. 28337- Journal article (peer-reviewed)abstract Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial infarction. Here, we explored the role of Neil3/NEIL3 in atherogenesis by both clinical and experimental approaches. Human carotid plaques revealed increased NEIL3 mRNA expression which significantly correlated with mRNA levels of the macrophage marker CD68. Apoe−/−Neil3−/− mice on high-fat diet showed accelerated plaque formation as compared to Apoe−/− mice, reflecting an atherogenic lipid profile, increased hepatic triglyceride levels and attenuated macrophage cholesterol efflux capacity. Apoe−/−Neil3−/− mice showed marked alterations in several pathways affecting hepatic lipid metabolism, but no genotypic alterations in genome integrity or genome-wide accumulation of oxidative DNA damage. These results suggest a novel role for the DNA glycosylase Neil3 in atherogenesis in balancing lipid metabolism and macrophage function, potentially independently of genome-wide canonical base excision repair of oxidative DNA damage.
2.	Smedbakken, LM, et al. (author) Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization 2012 In: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 224:1, s. 266-273 Journal article (peer-reviewed)
3.	Ueland, T, et al. (author) Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis 2009 In: Arteriosclerosis, thrombosis, and vascular biology. - 1524-4636. ; 29:8, s. 1228-1234 Journal article (peer-reviewed)
4.	Breland, UM, et al. (author) Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation 2010 In: Cardiovascular research. - : Oxford University Press (OUP). - 1755-3245 .- 0008-6363. ; 86:2, s. 265-273 Journal article (peer-reviewed)
5.	Ovchinnikova, OA, et al. (author) The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions 2014 In: Journal of internal medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 276:5, s. 525-536 Journal article (peer-reviewed)
6.	Sandberg, WJ, et al. (author) Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization 2006 In: Arteriosclerosis, thrombosis, and vascular biology. - 1524-4636. ; 26:4, s. 857-863 Journal article (peer-reviewed)

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Type of publication: journal article (6)

Type of content: peer-reviewed (6)

Author/Editor: Aukrust, P. (6); Ueland, T (6); Hansson, GK (6)Undo refine; Folkersen, L (5); Halvorsen, B (5); Gullestad, L (3); show more...; Hedin, U (3); Paulsson-Berne, G (3); Oie, E (3); Yndestad, A (3); Skjelland, M (3); Krohg-Sorensen, K (3); Holm, S (2); Russell, D (2); Sandberg, WJ (2); Damas, JK (2); Michelsen, AE (2); Scholz, H. (1); Gabrielsen, A (1); Persson, J. (1); Smith, C (1); Olofsson, PS (1); Robertson, AKL (1); Lindeman, JHN (1); Berge, RK (1); Bjorndal, B (1); Slupphaug, G (1); Muller, F (1); Lekva, T (1); Ketelhuth, DFJ (1); Ovchinnikova, O (1); Shlyakhto, E (1); Bjoras, M (1); Semb, AG (1); Iversen, PO (1); Olstad, OK (1); Lundberg, AM (1); Breland, UM (1); Otterdal, K (1); Froland, SS (1); Andreassen, AK (1); Scheffler, K (1); Fevang, B (1); Biessen, EAL (1); Ostlie, I (1); Biessen, EA (1); Svardal, AM (1); Nygard, S. (1); Ovchinnikova, OA (1); Gavrisheva, N (1); show less...

University: Karolinska Institutet (6)

Language: English (6)

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